CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis

Abstract

Cerebrovascular diseases (CVD) are dysfunctions of the brain, resulting from diseases of blood vessels supplying the brain. Atherosclerosis is one of the major underlying causes of CVD, in which inflammation plays a crucial role. One of the inflammatory mechanisms contributing to atherogenesis is the activation of monocytes and macrophages, which could be mediated by the bacterial endotoxin lipopolysaccharide (LPS) via its receptor CD14. The C260T (rs2569190) single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene was implicated in CVD. To assess the role of this SNP in CVD, a comprehensive meta-analysis of the available genetic data was conducted. All the case-control association studies evaluating the role of CD14 C260T in CVD were identified. Of these, 7 studies (comprising a total of 1488 patients and 1600 control subjects) were included in this meta-analysis. To measure the strength of genetic association for the gene variant, the odds ratios (ORs) were calculated using both fixed and random effects for comparisons of the alleles, the genotypes, and the dominant and recessive genotype models. The results showed there was no significant association between the T allele of C260T and the risk of CVD under the fixed effects model, OR = 0.99 (95% CI (0.89, 1.09)), P = 0.84; or the random effects model, OR = 0.99 (95% CI (0.88, 1.11)), P = 0.83. Similar results were obtained for the homozygotes and the dominant and recessive models. In conclusion, the results of this meta-analysis suggest the CD14 C260T polymorphism is not a risk factor for CVD. However, more studies in ethnically varied populations are needed to evaluate in a reliable manner the role of this SNP in CVD susceptibility.

ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease

“…The statistical heterogeneity was computed with the Q-statistic [46] (homogeneity rejected if P Q < 0.1 and/or I 2 > 75%) [47,48]. We calculated both Mantel-Haenszel (MH) (fixed effect (FE)) and random effects (RE) [49][50][51]. The effect was tested for the effect of the heterozygosity and for the dominant and the recessive models as well.…”

Association between <em>CD14 </em>rs2569190 C&gt;T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

“…In 2009, Banerjee41 conducted a meta-analysis on the association between CD14 rs2569190 C>T polymorphism and cerebrovascular diseases but did not conduct a subgroup analysis on IS susceptibility. Thereafter, Misra et al conducted a meta-analysis with only six published case–control studies and failed to find any significant association between CD14 rs2569190 C>T polymorphism and IS susceptibility 42.…”

Application of Multi-SNP Approaches Bayesian LASSO and AUC-RF to Detect Main Effects of Inflammatory-Gene Variants Associated with Bladder Cancer Risk

“…CD14 plays a major role in pathogen-activated signal transduction pathways and in the production of inflammatory cytokines [32]. CD14_IK- rs2569190 has been associated with prostate cancer in African Americans [33],and with coronary artery and cerebrovascular diseases [34], [35]. PRF1 codes for perforin 1, one of the main toxic proteins of cytolytic granules and a key effector in T-cell- and natural killer-cell-mediated cytolysis.…”