Helicobacter pylori infection and gastritis in healthy Nigerians

Abstract

In a study of forty asymptomatic volunteers from northern Nigeria; 35 (87.5%) had histological gastritis and 32 (80%) were infected by Helicobacter pylori. All but one of the patients infected by Helicobacter Pylori had histological gastritis. This high prevalence of H. Pylori infection in young, asymptomatic subjects, occurs in an area with a low prevalence of duodenal ulcer. The possible reasons for this are discussed.

Histopathological Pattern of Endoscopic Gastric Biopsy in a District Hospital in Nigeria: A Review of 118 Consecutive Cases

“…Compared with work done in a Sardjito General Hospital, Yogyakarta, Indonesia [8] and Ibadan, Nigeria [9] this is high compared with their 22.8% and 22.4% respectively. Our figure compared favourably with Shousha et al [10] among Yemins patients (94%); Rubio et al [11] among Mexicans (66%) and Holcombe et al (80%) in Maiduguri, Nigeria [12].…”

Analysis of geospecific markers for Helicobacter pylori variants in patients from Japan and Nigeria by triple-locus nucleotide sequence typing

“…These findings are consistent with previous investigations into H. pylori diversity from different individuals based on analyses of the same or different loci (Achtman et al, 1999;Solca et al, 2001;Owen et al, 2001a). A striking finding in our study was that the three selected gene sequences of H. pylori from individuals in Japan, a country with high rates of gastric cancer (Lambert et al, 2002), contained specific blocks of polymorphic sites that segregated such isolates and other East Asian isolates (clade A) from isolates in the Nigerian (African) population (clade B), in which gastric cancer rates are lower despite a high frequency of H. pylori infection (Holcombe et al 1992(Holcombe et al , 1994Campbell et al, 2001). Our findings agree with the analysis by Falush et al (2003) of 370 strains from 27 geographical, ethnic and/or linguistic human groupings that assigned almost all strains from various countries in East Asia to the hspEAsia subpopulation -one of three subpopulations in the modern population designated hpEastAsia.…”

“…In addition, one isolate from a dyspeptic patient in China (Jinan City, Shandon Province), and isolates from two Chinese patients who were UK residents, were included. The African set comprised eight isolates from patients in Nigeria (Maiduguri, Borno State) provided by Dr C. Holcombe (Holcombe et al, 1992(Holcombe et al, , 1994, and a further six strains that originated from patients (Cape-coloured population) in South Africa (Cape Town) provided by Dr A. Lastovica (Owen et al, 1992). The UK set comprised 23 isolates from 18 patients (white Caucasian and UK born) with paired (antrum and corpus) isolate sets from five individuals, and nine isolates from resident unrelated UK-Asians of Indian, Pakistani and Bangladeshi origin who were born outside the UK.…”

Aspects épidémiologiques et cliniques de l’infection à Helicobacter pylori à travers une étude marocaine

“…[12,13,14]. Dans la population étudiée, la prévalence de 69,2 % correspond bien aux prévalences notées dans les pays en voie de développement [15,16]. Nous n'avons pas mis en évidence de différence significative de prévalence entre les hommes et les femmes comme dans la plupart des études [17] contrairement à certaines où une prévalence plus élevée chez l'homme a été reliée à une exposition plus importante [18].…”