Aspects épidémiologiques et cliniques de l’infection à <i>Helicobacter pylori</i> à travers une étude marocaine

Essadik, Amel; Benomar, Hakima; Ismaïl, Rafik; Hamza, Mouna; Guemouri, Laïla; Kettani, Anass; Maachi, Fatima

doi:10.4267/2042/51450

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…Our study showed that the most common pathology resulting from H. pylori infection was chronic gastritis with a rate of 66%, followed by atrophic gastritis (12%), intestinal metaplasia (8%), and gastric cancer (9%). We also observed that the prevalence of gastric cancer (9%) in infected patients was higher compared to other studies that showed that the prevalence of risk to develop gastric cancer related to H. pylori was between 1 and 3% [7,31].…”

Section: Discussionsupporting

confidence: 53%

“…In the majority of cases, H. pylori infection induces chronic gastritis with a rate of 80% to 90% and to 10% of infected individuals can develop peptic ulcers and 1-3% presents a risk of developing gastric cancer [7,[30][31][32]. Our study showed that the most common pathology resulting from H. pylori infection was chronic gastritis with a rate of 66%, followed by atrophic gastritis (12%), intestinal metaplasia (8%), and gastric cancer (9%).…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Bounder¹,

Boura²,

SalouaNadifiyine³

et al. 2017

JLS

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Abstract:Helicobacter pylori (H. pylori) colonize the gastric mucosa of 50% of the world's population. This infection is closely associated with the development of peptic ulcer disease and gastric cancer. The present study was conducted to assess the prevalence of H. pylori infection in Moroccan population and the risk to develop gastric precancerous lesions and gastric cancer. Totally, 298 patients were enrolled, 68 of asymptomatic subjects and 230 of patients with gastric diseases. Histological examination was effected to diagnostic gastric lesions and to detect H. pylori. ELISA was used to determine H. pylori status of patients. The prevalence of H. pylori within asymptomatic and symptomatic subjects was observed higher. A significant relationship was detected between H. pylori infection and the risk of gastric diseases (p-value < 0.0001). A meaningful association between chronic gastritis increasing and age was observed (p-value = 0.03). The risk to develop gastric cancer among infected patients was observed elevated with rate of 9%. Our results showed a high prevalence of H. pylori in both asymptomatic and gastric diseases patients. We noticed that chronic gastric infection increases with age. We remarked also that the risk to develop gastric cancer among infected patients was elevated in our population.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Bounder¹,

Boura²,

SalouaNadifiyine³

et al. 2017

JLS

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“…In Morocco, the prevalence of H . pylori infection is 69.2% corresponds well to the prevalence noted in developing countries [ 16 ]. While in our studied population, the prevalence rate was 66.12%.…”

Section: Discussionmentioning

confidence: 62%

Epidemiological Profile of Helicobacter pylori Infection in Patients with Digestive Symptoms in Algeria

Kasmi

Doukani

Ali³

et al. 2020

JEGH

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“…Epidemiological studies have shown that H. pylori infections are a major public health problem in Morocco, affecting approximately 70% of the population. Epigastric pain is common, and ulcerative disease affects about 5% of the Moroccan population, including young children and adults [2,3].…”

Section: Introductionmentioning

confidence: 99%

Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages

et al. 2020

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Introduction: Helicobacter pylori induces acute gastritis that can progress to serious diseases such as gastric cancer. H. pylori interacts with host cells within the gastric mucosa, resulting in activation of multiple innate immune signalling pathways, leading to proinflammatory cytokines production and immune cells recruitment. Various studies have shown that there are ethnic-and population-related differences in the expression of these cytokines. Although the H. pylori infection is a major public health problem in Morocco, to our knowledge, no study has been carried out in gastric cytokine expression from H. pylori-infected Moroccan patients. Thus we aimed to i) determine the IL-1β, IL-8 and IL-17A gene expression in gastric biopsies from Moroccan patients infected with H. pylori, and ii) to determine the cytokine signature of each pathological stages associated with this infection. Material and methods: 71 patients with epigastralgic pain were included in this study. The H. pylori detection on gastric biopsies was performed by histopathological and PCR analysis. The IL-1β, IL-8 and IL-17A mRNA expression in the antrun and fundus biopsies was performed by RT-qPCR. Results: The histopathological and PCR analyses revealed that 87.32% of the patients were infected with H. pylori. IL-1β mRNA expression was significantly lower in the antral mucosa of H. pylori-infected patients (p = 0.0038) than in the uninfected while there was no significant difference in the expression of IL-8 and IL-17A mRNA. The expression of the three cytokines was higher in the fundic mucosa of H. pylori-infected patients than in the uninfected patients, but only IL-8 and IL-17A expression reached statistical significance (p = 0.042 and p = 0.0179 respectively). Furthermore, the multivariate predictive analysis highlighted a cytokine signature that may predict metaplasia during the infection progression that involves a specific down-regulation of IL17A and an up-regulation of IL1β in antral and fundic metaplasia respectively.

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Aspects épidémiologiques et cliniques de l’infection à Helicobacter pylori à travers une étude marocaine

Cited by 6 publications

References 11 publications

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Epidemiological Profile of Helicobacter pylori Infection in Patients with Digestive Symptoms in Algeria

Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages

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