Helicobacter pylori infection among patients with upper gastrointestinal symptoms: prevalence and relation to endoscopy diagnosis and histopathology

Shrestha, Ranjana; Koirala, Kamal; Raj, KC Shiv; Batajoo, Kabita Hada

doi:10.4103/2249-4863.137663

Cited by 22 publications

(30 citation statements)

References 15 publications

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“…Although it was varied between studies (16.3–70.5 %) [14–19], we confirmed the prevalence of H. pylori infection is 38.4 % (56/146) using several diagnostic test that significantly related to source of drinking water [20]. The majority of strains are so-called Western-type- cagA in Nepal as similar to typical South Asian patterns [20].…”

Section: Introductionsupporting

confidence: 74%

Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal

et al. 2016

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BackgroundThe prevalence of Helicobacter pylori antibiotic susceptibility in the Nepalese strains is untracked. We determined the antibiotic susceptibility for H. pylori and analyzed the presence of genetic mutations associated with antibiotic resistance in Nepalese strains.ResultsThis study included 146 consecutive patients who underwent gastroduodenal endoscopy in Kathmandu, Nepal. Among 42 isolated H. pylori, there was no resistance to amoxicillin and tetracycline. In contrast, similar with typical South Asian patterns; metronidazole resistance rate in Nepalese strains were extremely high (88.1 %, 37/42). Clarithromycin resistance rate in Nepalese strains were modestly high (21.4 %, 9/42). Most of metronidazole resistant strains had highly distributed rdxA and frxA mutations, but were relative coincidence without a synergistic effect to increase the minimum inhibitory concentration (MIC). Among strains with the high MIC, 63.6 % (7/11) were associated with frameshift mutation at position 18 of frxA with or without rdxA involvement. However, based on next generation sequencing data we found that one strain with the highest MIC value had a novel mutation in the form of amino acid substituted at Ala-212, Gln-382, Ile-485 of dppA and Leu-145, Thr-168, Glu-117, Val-121, Arg-221 in dapF aside from missense mutations in full-length rdxA. Mutations at Asn-87 and/or Asp-91 of the gyrA were predominantly in levofloxacin-resistant strains. The gyrB mutation had steady relationship with the gyrA 87–91 mutations. Although three (44.4 %) and two (22.2 %) of clarithromycin resistant strains had point mutation on A2143G and A2146G, we confirmed the involvement of rpl22 and infB in high MIC strains without an 23SrRNA mutation.ConclusionsThe rates of resistance to clarithromycin, metronidazole and levofloxacin were high in Nepalese strains, indicating that these antibiotics-based triple therapies are not useful as first-line treatment in Nepal. Bismuth or non-bismuth-based quadruple regimens, furazolidone-based triple therapy or rifabutin-based triple therapy may become alternative strategy in Nepal.Electronic supplementary materialThe online version of this article (doi:10.1186/s12866-016-0873-6) contains supplementary material, which is available to authorized users.

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Section: Introductionsupporting

confidence: 74%

Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal

et al. 2016

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“…In the present study, the prevalence of H. pylori among patients with dyspepsia were 81.7%. This was higher than that reported by Alhussaini (14) (71.33%), Roshana et al (15) (68%) and Adlekha et al (16) (62.0%). Egypt is a multiracial country, the different races although living together, have exclusive habits and cultural practices peculiar to their own.…”

Section: Discussioncontrasting

confidence: 60%

Pattern of Endoscopic Esophageal Findings in Relation to Helicobacter Pylori Infection and Histopathology: A Single Center Experience

Moussa

Gawad

Nosseir

2019

Suez Canal University Medical Journal

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Background: Dyspepsia is a common complain among people suffering from gastrointestinal diseases. Few researches investigated the underlying causes in detail. H. Pylori is considered a major finding in patients with dyspepsia and diagnosed with gastrointestinal diseases. Aim: The aim of this study is to determine the pattern of Endoscopic Esophageal lesion in Relation to H. Pylori infection and histopathological features of esophageal and gastric mucosal biopsies in dyspeptic patients eligible for upper GIT Endoscopy. Patients and Methods: all the patients presented with dyspeptic symptoms and were eligible for upper GIT endoscopy during the period from January 2016 to January 2019were included (n=60). Using endoscopy, gastric biopsies were taken for H. Pylori examination and esophageal lesions biopsies were taken for histopathological examination (n=120 specimens). Results: the prevalence of H. pylori among patients with dyspepsia was 81.7%. The most common endoscopic esophageal pattern with H. pylori was erythema and abnormal vascular pattern (67.3%). Reflux esophagitis was the most common Histopathological finding in H. Pylori positive patients (57.1%). Chronic non-specific esophagitis was higher in H. Pylori negative (9.1%) compared with H. Pylori positive (8.2%). Adenocarcinoma was found in 16.3% of H. Pylori positive patients, however, squamous cell carcinoma was more in H. Pylori negative (27.3%) than H. Pylori positive (6.1%). Conclusion: The majority of patient with dyspepsia has H. Pylori infection. Risk factors for malignant esophageal lesions are old age, male gender, smoking and H. pylori infection

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“…Patients with chronic active gastritis and chronic follicular gastritis had higher frequency of Helicobacter Pylori positivity with incidence of 84.8% and 84.1% respectively. Higher incidence of Helicobacter Pylori were also seen in other studies done by Shrestha R et al 20 Other studies also identified association between ulcerative lesions and higher incidence of Helicobacter Pylori. [21][22][23] Study done by X Y Chen et al observed positive correlation with the prevalence and density of lymphoid follicles and aggregates with H pylori infection.…”

supporting

confidence: 70%

“…18 Reflux esophagitis was observed in 10% of the patients which was less than study conducted by Ercelep OB et al 19 Ulcerative lesions of stomach and duodenum was more common in males than in females as was observed in a study done by Shrestha R et al 20 Most common pathology in histopathology was chronic active gastritis (42.1%), followed by chronic persistent gastritis (38.2%), chronic follicular gastritis (19.1%) and gastric carcinoma (0.5%). This result was in concordance with other study.…”

contrasting

confidence: 40%

“…This result was in concordance with other study. 20 In ulcerative lesions most common antral biopsy finding was chronic active gastritis and chronic follicular gastritis whereas in non-ulcerative lesions chronic persistent gastritis was the commonest diagnosis. Patients with chronic active gastritis and chronic follicular gastritis had higher frequency of Helicobacter Pylori positivity with incidence of 84.8% and 84.1% respectively.…”

mentioning

confidence: 99%

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Prevalence of Helicobacter pylori among patients with dyspepsia and correlation between endoscopic and histological diagnosis

Lakhey²,

Koirala³

et al. 2016

J Pathol Nep

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Background: Dyspepsia is a prevalent complaint in general practice and gastrointestinal clinics. Helicobacter pylori have major causal relationship with gastro duodenal disease. The following study seeks to identify the prevalence of H. pylori based on histology and to correlate endoscopic findings with histopathology. Materials and Methods:This was a cross-sectional observational study conducted in GRP Polyclinic and Om Hospital and research centre from April 2015-September 2015. The upper gastrointestinal endoscopic findings were recorded and were correlated with histopathological findings. All the relevant data were collected and analysed using Statistical Package of Social Sciences version 16 for windows.Results: Endoscopy finding was divided into reflux esophagitis, antral gastritis, duodenitis, duodenal ulcer, gastric ulcer, and gastric cancer. Duodenal ulcer and gastric ulcer was noted more frequently in males than in females (55.0% vs. 45.0% and 58.2% vs. 41.8%), respectively, P < 0.001).Chronic follicular gastritis was the most common in gastric ulcer (41.7%), whereas chronic persistent gastritis was common in non-ulcerative disease. Chronic active gastritis and chronic follicular gastritis were more common in ulcerative diseases, whereas chronic persistent gastritis was more common in gastritis and duodenitis (P < 0.001). The overall prevalence of H. pylori infection was 68.1% with male preponderance. Chronic active gastritis had highest prevalence of H. pylori (84.8%), followed by chronic follicular gastritis (84.1%) and chronic persistent gastritis (p value < 0.001. Conclusion:Rate of H. pylori infected patients with dyspepsia was high. Ulcerative lesions were more common in males than in females with higher rate of infection with H. Pylori. Histological diagnosis of chronic active gastritis and chronic follicular gastritis was the most common pathologies in ulcerative lesions.

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Helicobacter pylori infection among patients with upper gastrointestinal symptoms: prevalence and relation to endoscopy diagnosis and histopathology

Cited by 22 publications

References 15 publications

Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal

Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal

Pattern of Endoscopic Esophageal Findings in Relation to Helicobacter Pylori Infection and Histopathology: A Single Center Experience

Prevalence of Helicobacter pylori among patients with dyspepsia and correlation between endoscopic and histological diagnosis

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