Helicobacter pylori in Rosacea: Lack of an Association

Jones, Michael P.; Knable, Alfred L.; White, Michael; Durning, Steven J.

doi:10.1001/archderm.134.4.511

Cited by 49 publications

(31 citation statements)

References 1 publication

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“…Since then, several studies have shown an elevated prevalence of H. pylori infection in patients with rosacea (15,(26)(27)(28), even when compared with age-and sex-matched control patients (29). In contrast, other authors could not show a higher prevalence of infection in these patients (4,(30)(31)(32)(33)(34).…”

Section: Resultscontrasting

confidence: 66%

Effect of Helicobacter pylori eradication therapy in rosacea patients

Miquel

Romero

Sequeiros

et al. 2006

Rev. esp. enferm. dig.

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Objective: the causal relation between rosacea and Helicobacter pylori infection is discussed. We evaluated the clinical evolution of rosacea after infection eradication.Patients and methods: we have prospectively studied 44 patients diagnosed with rosacea. Helicobacter pylori infection was determined, and infected patients were treated with eradication therapy. The evolution of dermatological symptoms in a subgroup of 29 infected patients in whom eradication had been achieved was followed during 16.8 (± 17.8) months. Median age was 50.6 (± 14.1) years for 22 women (75.9%) and 7 men (24.1%). Clinical response according to gender and clinical subtype of rosacea was evaluated.Results: complete improvement was observed in 10 patients (34.5%; 95% CI: 18.6-54.3%), relevant improvement in 9 (31.1%; 95% CI: 16-51%), poor improvement in 5 (17.2%; 95% CI: 6.5-36.4%), and absence of improvement in 5 cases (17.2%; 95% CI: 6.5-36.4%). No significant differences in dermatological evolution according to sex were observed. Regarding subtype of rosacea there was a relevant improvement in 83.3% (95% CI: 64.1-93.8%) of cases with papulopustular type as opposed to 36.5% (95% CI: 20-56.1%) of cases with erythematous predominance, p = 0.02.Conclusions: based on these results, the relation between Helicobacter pylori and rosacea is supported, and infection should be investigated in these patients because an appreciable percentage of patients diagnosed with rosacea and Helicobacter pylori infection can benefit from eradication therapy, mainly in the papulopustular subtype.

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Section: Resultscontrasting

confidence: 66%

Effect of Helicobacter pylori eradication therapy in rosacea patients

Miquel

Romero

Sequeiros

et al. 2006

Rev. esp. enferm. dig.

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“…7,10 Other studies, however, did not find any significant difference in the prevalence of H. pylori infection between rosacea patients and controls. [19][20][21] This apparent discrepancy might be due to the different method of evaluation of H. pylori infection between these studies and ours (i.e. serology versus 13 C UBT, respectively).…”

Section: Discussioncontrasting

confidence: 57%

Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea

Gravina¹,

Federico²,

Ruocco

et al. 2015

UEG Journal

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Background and aims: Recent studies suggest a potential relationship between rosacea and Helicobacter pylori (H. pylori) infection or small intestinal bacterial overgrowth (SIBO), but there is no firm evidence of an association between rosacea and H. pylori infection or SIBO. We performed a prospective study to assess the prevalence of H. pylori infection and/or SIBO in patients with rosacea and evaluated the effect of H. pylori or SIBO eradication on rosacea. Methods: We enrolled 90 patients with rosacea from January 2012 to January 2013 and a control group consisting of 90 patients referred to us because of mapping of nevi during the same period. We used the 13 C Urea Breath Test and H. pylori stool antigen (HpSA) test to assess H. pylori infection and the glucose breath test to assess SIBO. Patients infected by H. pylori were treated with clarithromycin-containing sequential therapy. Patients positive for SIBO were treated with rifaximin. Results: We found that 44/90 (48.9%) patients with rosacea and 24/90 (26.7%) control subjects were infected with H. pylori (p ¼ 0.003). Moreover, 9/90 (10%) patients with rosacea and 7/90 (7.8%) subjects in the control group had SIBO (p ¼ 0.6). Within 10 weeks from the end of antibiotic therapy, the skin lesions of rosacea disappeared or decreased markedly in 35/36 (97.2%) patients after eradication of H. pylori and in 3/8 (37.5%) patients who did not eradicate the infection (p < 0.0001). Rosacea skin lesions decreased markedly in 6/7 (85.7%) after eradication of SIBO whereas of the two patients who did not eradicate SIBO, one (50%) showed an improvement in rosacea (p ¼ 0.284). Conclusions: Prevalence of H. pylori infection was significantly higher in patients with rosacea than control group, whereas SIBO prevalence was comparable between the two groups. Eradication of H. pylori infection led to a significant improvement of skin symptoms in rosacea patients.

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“…Porém, mais especificamente, a associação da rosácea com a sorologia reagente ao Hp foi de fato demonstrada, reforçando-se após ser utilizada a análise estratificada de Mantel-Haenzel, que, analisando o estrato de casos e controles isentos do uso de antibióticos, demonstrou diferença significante para associação do Hp com a rosácea, (p < 0,05 e OR = 1,54). [12][13][14][15] À histopatologia, as alterações inflamatórias dérmicas e os "microaneurismas", provavelmente derivados de fusionamentos de capilares telangiectási-cos (fenômeno denominado "regressivo" por Neumann e Frithz) 5 e da neovascularização, foram constantes nas lâminas examinadas.…”

Section: Discussionunclassified

Fatores associados à rosácea em amostras populacionais do Sul do Brasil: análise de estudos casos-controles

Bonamigo

Bakos

Cartell

et al. 2008

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS -A rosácea é dermatose que apresenta uma série de variáveis associadas a seu surgimento. A maioria dos estudos é proveniente dos Estados Unidos da América e de países europeus, sendo escasso o conhecimento produzido e publicado acerca da doença no Hemisfério Sul, particularmente no Brasil. OBJETIVOS -Descrever os principais fatores clínicos e histopatológicos associados à rosácea em amostras populacionais do sul do Brasil. MÉTODOS -Dois estudos casos-controles realizados em seqüência, com análise univariada e bivariada, utilizando-se p < 0,05 para significância estatística (teste do qui-quadrado e Mantel-Haenzel, quando realizadas estratificações). RESULTADOS -A rosácea é mais freqüente em mulheres e na faixa de 40-50 anos. Os pacientes com fototipos II e III configuram a quase-totalidade dos casos, as formas inflamatórias da rosácea são mais diagnosticadas do que a vascular, e há associação com a sorologia positiva para Helicobacter pylori e com a presença histopatológica do Demodex folliculorum (p < 0,05). As alterações emocionais e climáticas, a exposição solar e o uso de bebidas alcoólicas foram os principais fatores descritos como provocativos ou agravantes. CONCLUSÕES -Apresenta-se um panorama da rosácea obtido em amostra de população sulista do Brasil, com alguns dados semelhantes aos já descritos internacionalmente e outros particularizados, como a questão econômica e os fatores descritos como provocativos ou agravantes. Palavras-chave: Helicobacter pylori; Helicobacter pylori/isolamento e purificação; Rosácea; Rosácea/epidemiologia; Rosácea/etiologia; Rosácea/patologia Abstract: BACKGROUND -Rosacea is a dermatosis that has many factors associated with its onset. Most studies on this condition come from the United States and European countries, with little information produced and published about the disease in the Southern

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Helicobacter pylori in Rosacea: Lack of an Association

Cited by 49 publications

References 1 publication

Effect of Helicobacter pylori eradication therapy in rosacea patients

Effect of Helicobacter pylori eradication therapy in rosacea patients

Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea

Fatores associados à rosácea em amostras populacionais do Sul do Brasil: análise de estudos casos-controles

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