Helicobacter pylori IN RENAL TRANSPLANT RECIPIENTS

Teenan, R. P.; Burgoyne, Margaret; Brown, Ian; Murray, William R.

doi:10.1097/00007890-199307000-00018

Cited by 20 publications

(16 citation statements)

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“…Teenan et al and Davenport et al reported a prevalence of 48 and 29%, respectively. [2627] In the study by Teenan et al , no relationship was observed between H. pylori colonization and cyclosporine or prednisolone levels,[26] suggesting other possible mechanisms for the lower prevalence of H. pylori and hence, the higher frequencies of GERD in this group of patients. Possible protective mechanisms include the frequent use of antibiotics in RTRs[28] resulting in changes in bacterial colonization of the upper GI tract.…”

Section: Discussionmentioning

confidence: 83%

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Abdul-Rahman

Al-Quorain

2008

Saudi J Gastroenterol

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Background/Aims:The prevalence of gastroesophageal reflux disease (GERD) in chronic renal failure patients and in renal transplant recipients (RTR) has been a subject of discussion in the last few years. Our aims are to clarify this association and its relation to Helicobacter pylori infection, and also to identify possible pathogenic factors in the development of this disease in both groups.Methods:The study involved 40 end-stage renal disease (ESRD) patients with upper gastrointestinal (GI) symptoms (group I), 36 patients who had undergone kidney transplantation and had similar symptoms (group II), and 44 age- and sex-matched controls with the same upper GI symptoms (group III). All patients were subjected to esophagogastroduodenoscopy, and biopsies were obtained from the antrum for histological evaluation and identification of H. pylori.Results:The prevalence of GERD in the first two groups was similar (77.5 vs. 75.0%, P = 0.412), while it was significantly lower in the control group (38.6%, P < 0.01). H. pylori infection was present in 40.0, 36.1 (P > 0.05) and 75% (P < 0.01 and < 0.001) of the patients in groups I, II, and III, respectively. Multivariate logistic regression analysis in groups I and II showed that high serum creatinine (Odds ratio [OR] = 6.78, 95% Confidence Interval (CI) = 1.12-45.82), immunosuppressive therapy (OR = 5.78, 95% CI = 1.01-32.5), and absence of H. pylori infection (OR = 3.58, 94% CI = 1.11-18.6) were significantly associated with GERD. The duration of ESRD correlated significantly with the prevalence of GERD in group I.Conclusions:This study showed a similar prevalence of H. pylori infection and GERD in ESRD and RTR patients. GERD prevalence was higher in these two groups than in the controls. Renal transplantation, chronic renal disease, immunosuppressive therapy, and the absence of H. pylori infection seem to be risk factors for the development of GERD.

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Section: Discussionmentioning

confidence: 83%

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Abdul-Rahman

Al-Quorain

2008

Saudi J Gastroenterol

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“…In a recent study from our center, the prevalence of H. pylori in adult HD patients and RTR was rather high, but very similar to patients without renal disease [8]. However, some studies have shown the prevalence of H. pylori among HD patients to be significantly lower than in the healthy population, while some have indicated an increased prevalence [6,[9][10][11][12]. The prevalence of H. pylori infection in children with gastroduodenal lesions has differed according to the study [13,14].…”

Section: Introductionmentioning

confidence: 86%

Gastroduodenal lesions and Helicobacter pylori in children with end-stage renal disease

Emir

Bereket

Boyacıoğlu

et al. 2000

Pediatric Nephrology

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Thirty-seven children with end-stage renal disease were evaluated for gastroduodenal lesions by upper gastrointestinal endoscopy between January 1993 and January 1998. The mean (+/-SD) age of the patients was 14.3+/-2.4 years (range 9-17 years). Endoscopic examination was abnormal in 17 patients (46%). The lesions were antral gastritis plus bulbitis (n=6), nodular bulbitis (n=4), antral gastritis (n=4), and duodenal ulcer (n=3). Fifteen patients had symptoms related to gastroduodenal disease, whereas 22 patients were asymptomatic at the time of endoscopic examination; 80% of the symptomatic and 23% of the asymptomatic patients had gastroduodenal lesions on endoscopy. Antral mucosal biopsy was taken from 26 of 37 children for the detection of Helicobacter pylori by the urease test. H. pylori was detected in 10 of 16 patients with gastroduodenal lesions (8 symptomatic, 2 asymptomatic). None of the patients with normal endoscopic examination were positive for H. pylori. Thus, we have demonstrated a significant number of gastroduodenal lesions and their frequent association with H. pylori in our pediatric renal transplant candidates. Our results emphasize the importance of gastrointestinal evaluation in these patients. Endoscopic examination should be considered in symptomatic patients and in areas where H. pylori is endemic.

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“…Why H.pylori infection is low in dialysis patients in spite of their immune-compromised status is not very clear. In an attempt to find an explanation, Teenan et al, 18 Davenport et al 17 and Abdul-Rahman et al 58 61 They found that after six weeks of intermittent hemodialysis, in vitro T-cell proliferation on stimulation improved significantly (stimulation index, 21.6 +/-18.5 vs 58.1 +/-45.5; P<0.01). This improvement occurred regardless of whether synthetic dialyzers or cellulose membranes were used for the initiation of dialysis.…”

Section: Discussionmentioning

confidence: 99%

Gastroduodenal Lesions in Peritoneal Dialysis Patients: The Role of Helicobacter Pylon Infection

Abdul-Rahman

Al-Hwiesh

2012

Nephrology Research & Reviews

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The aim of this study was to examine the prevalence of Helicobacter pylori infection and the associated gastroduodenal lesions in peritoneal dialysis patients. Ninety-eight patients with dyspeptic complaints were included in the study. They were divided into two groups; group 1 consisted of 48 patients with endstage renal disease (ESRD) on PD and group 2 (control) of 50 patients without renal disease. All patients were subjected to upper gastrointestinal endoscopies, and gastric biopsies were obtained for histological evidence of H.pylori infection. Anti-H.pylori IgG antibodies were tested in the PD patients using the ELISA test. The mean age of both groups was similar. Twenty-three (47.9%) of the 48 patients on PD and 25 (50.0 %) of the 50 nonrenal disease patients were positive for H.pylori infection. There was no significant difference in H.pylori prevalence between the two groups (P>0.05). No correlation was found between H.pylori infection and age, sex, primary disease, or type (CAPD or APD). However, prevalence was significantly higher (30.4% vs 17.4%, P<0.001) in patients who were on PD for less than 24 months. False positive serology for H.pylori in the absence of positive histology was found in 7 out of the 25 negative cases (28.0 %) in the dialysis group. The prevalence of duodenal ulcers was significantly higher in H.pylori positive than in H.pylori negative ESRD patients on PD (18.8% vs 8.3%, P<0.05). Gastroesophageal reflux disease (GERD) was seen in 21 (43.8%) patients in group 1 and in 8 (16%) cases in group 2 (P<0.01). GERD was, however, significantly lower in H.pylori positive patients in both groups (12.5% vs 31.3% in group 1 and 4% vs 12% in group 2, P<0.001 and P<0.01, respectively). In conclusion, long-term PD seems to decrease the prevalence of H.pylori infection. Testing H.pylori antibodies lacks specificity for diagnosing active H.pylori infection in PD patients. H.pylori infection in patients on PD is associated with increased risk of gastroduodenal lesions and decreased prevalence of GERD

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Helicobacter pylori IN RENAL TRANSPLANT RECIPIENTS

Cited by 20 publications

References 0 publications

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Gastroduodenal lesions and Helicobacter pylori in children with end-stage renal disease

Gastroduodenal Lesions in Peritoneal Dialysis Patients: The Role of Helicobacter Pylon Infection

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