Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Abdul-Rahman, Ibrahiem Saeed; Al-Quorain, Abdulaziz

doi:10.4103/1319-3767.41741

Cited by 12 publications

(18 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was seen by Neri et al that those patients who had upper GI symptoms, prior to transplant, were more prone to experience it post-transplant as well [ 6 ]. Mean urea and creatinine in our study was 58.34 ± 39.3 mg/dL and 2.11 ± 1.1 mg/dL respectively, this was higher than that of Saudi Arabia's population, have mean creatinine of 1.6 ± 1.1 mg/dL, but this had no association with factors leading to dyspepsia [ 7 ]. Deranged urea and creatinine, has been considered as one of the known cause of dyspepsia in these patients [ 6 ].…”

Section: Discussionmentioning

confidence: 66%

“…A study done at Istanbul also finds gastritis as the most common finding on endoscopy, seen in 55 (85.9%) patients [ 15 ]. Abdur Rehman and Al Qurain's observation was contrasting and found that GERD was more common in renal transplanted patients in comparison with gastritis [ 7 ]. In our study frequency of H. Pylori was less as compare to the other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Neri et al concluded that female gender (39.9%), hypertension (22.5%) and renal failure secondary to type I DM (12.1%) have increased risk of dyspepsia [ 6 ]. Raised creatinine is one of the risk factor of dyspepsia in post renal transplant era [ 7 , 8 ]. In normal population increased age and smoking are risk factors of dyspepsia [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors leading to dyspepsia in renal transplant recipients

Nazeer¹,

Aslam²,

Luck³

2017

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionRenal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study was to determine factors leading to dyspepsia in renal (kidney) transplant recipients.MethodsIt was a cross sectional study conducted at department of hepatogastroenterology and transplant sciences, SIUT Karachi, from 1-6-15 to 1-12-15 for six months. All renal transplanted patients having dyspeptic symptoms for more than 6 weeks. EGD was performed, biopsy specimens obtained from antrum and duodenum, these were sent for histopathological examination. Frequency and percentages were obtained for categorical variables, mean ± SD was calculated for continuous variables. Chi square test was used for categorical variable and student t-test for continuous variables.ResultsNinety patients were included in the study out of which 64 (71.1%) were males, mean age was 35.82 ± 10.04 years (range: 18-65 years). Gastritis (non H.pylori associated) in 78 (78.6%), duodenitis in 35 (38.9%) and H. pylori infection in 29 (32.2%), renal transplant recipients. Most of the patients belonged to Sindhi ethnicity, 27 (30%), followed by Punjabi. Hypertension was the most common co-morbid condition in our patients found in 29 (32.2%), while most of them don't have any co morbid condition. Duodenitis was found to be associated with tacrolimus use (p = 0.037).ConclusionGastritis is the most common factor accountable for this symptoms, followed by duodenitis and H. Pylori. Patients taking tacrolimus as immunosuppressant are more prone to develop duodenitis.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Factors leading to dyspepsia in renal transplant recipients

Nazeer¹,

Aslam²,

Luck³

2017

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…Why H.pylori infection is low in dialysis patients in spite of their immune-compromised status is not very clear. In an attempt to find an explanation, Teenan et al, 18 Davenport et al 17 and Abdul-Rahman et al 58 61 They found that after six weeks of intermittent hemodialysis, in vitro T-cell proliferation on stimulation improved significantly (stimulation index, 21.6 +/-18.5 vs 58.1 +/-45.5; P<0.01). This improvement occurred regardless of whether synthetic dialyzers or cellulose membranes were used for the initiation of dialysis.…”

Section: Discussionmentioning

confidence: 99%

Gastroduodenal Lesions in Peritoneal Dialysis Patients: The Role of Helicobacter Pylon Infection

Abdul-Rahman

Al-Hwiesh

2012

Nephrology Research & Reviews

View full text Add to dashboard Cite

The aim of this study was to examine the prevalence of Helicobacter pylori infection and the associated gastroduodenal lesions in peritoneal dialysis patients. Ninety-eight patients with dyspeptic complaints were included in the study. They were divided into two groups; group 1 consisted of 48 patients with endstage renal disease (ESRD) on PD and group 2 (control) of 50 patients without renal disease. All patients were subjected to upper gastrointestinal endoscopies, and gastric biopsies were obtained for histological evidence of H.pylori infection. Anti-H.pylori IgG antibodies were tested in the PD patients using the ELISA test. The mean age of both groups was similar. Twenty-three (47.9%) of the 48 patients on PD and 25 (50.0 %) of the 50 nonrenal disease patients were positive for H.pylori infection. There was no significant difference in H.pylori prevalence between the two groups (P>0.05). No correlation was found between H.pylori infection and age, sex, primary disease, or type (CAPD or APD). However, prevalence was significantly higher (30.4% vs 17.4%, P<0.001) in patients who were on PD for less than 24 months. False positive serology for H.pylori in the absence of positive histology was found in 7 out of the 25 negative cases (28.0 %) in the dialysis group. The prevalence of duodenal ulcers was significantly higher in H.pylori positive than in H.pylori negative ESRD patients on PD (18.8% vs 8.3%, P<0.05). Gastroesophageal reflux disease (GERD) was seen in 21 (43.8%) patients in group 1 and in 8 (16%) cases in group 2 (P<0.01). GERD was, however, significantly lower in H.pylori positive patients in both groups (12.5% vs 31.3% in group 1 and 4% vs 12% in group 2, P<0.001 and P<0.01, respectively). In conclusion, long-term PD seems to decrease the prevalence of H.pylori infection. Testing H.pylori antibodies lacks specificity for diagnosing active H.pylori infection in PD patients. H.pylori infection in patients on PD is associated with increased risk of gastroduodenal lesions and decreased prevalence of GERD

show abstract

“…Bildirilen insidansı araştırma yöntemine bağlı olarak % 12 ile % 55 arasında değişmektedir (1,2,3).Özellikle retrosternal yanma ve regürjitasyon, son dönem böbrek hastalığı (SDBH) olanlarda ve renal transplant alıcılarında sık görülen bulgular olup, bu şikayetler gastroözofageal reflü hastalığına bağlı olabilir (4,5). Bu hasta gruplarında gastroözofageal reflü hastalığının (GÖRH) prevalansı son birkaç yıldır tartışılmaya başlamıştır ve bu durum hakkında çok az bilgi mevcuttur (6). GÖRH gastrik içeriğin yemek borusuna geri dönüşü olarak tanımlanır.…”

Section: Introductionunclassified

Renal Transplant Alıcılarında Gastroözefageal Reflü Hastalığı Belirtilerinin Değerlendirilmesi

Özkurt¹,

Sağlan²,

Mengus³

2018

Osmangazi̇ Journal of Medicine

View full text Add to dashboard Cite

Özet: Gastrointestinal semptomlar, özellikle retrosternal yanma ve regürjitasyon, son dönem böbrek hastalarında (SDBH) ve renal transplant alıcılarında sık görülen bulgulardır. Kronik böbrek hastalarında ve böbrek nakli yapılan hastalarda gastroözofageal reflü hastalığının (GÖRH) prevalansı son birkaç yıldır tartışılmaya başlamıştır. Ülkemizde renal transplant alıcılarında GÖRH prevelansı araştırılmamıştır. Bu çalışmada renal transplant alıcılarında GÖRH sıklığını ve ilişkili olduğu faktörleri araştırmayı amaçladık. Kesitsel tipteki bu çalışmaya 69 fonksiyone grefte sahip renal transplant alıcısı hasta dahil edildi. Hastaların gastrointestinal sistem şikayetleri, özgeçmiş özellikleri ve kullandıkları ilaçlar yüz yüze görüşme yöntemi ile elde edildi. Anket formu, bireylerin sosyodemografik özelliklerini, GÖRH ile ilişkili olduğu düşünülen bazı faktörler ile ilgili soruları içermekteydi. Çalışmada GÖRH'ün değerlendirilmesinde National İnstitutes of Health (NIH) PROMİS GERD Ölçeği kullanıldı. Çalışmaya dahil edilen hastaların 32'si (%46.4) erkek, 37'si (%53.6) ise kadındı. Hastaların yaşları 22-66 arasında değişmekte olup, yaş ortalamaları 44.86±11.26 yıl idi. Hastalarda GÖRH sıklığı %21.7 oranında tespit edildi. Hastaların %79.7'si gastroprotektif ajan kullanmakta idi. GÖRH olanlarla olmayanlar arasında yaş, cinsiyet, vücut kitle indeksi, glomeruler filtrasyon hızı (eGFR), sigara kullanımı, medeni durum, gastroprotektif ilaç kullanımı, nonsteroid antienflamatuar ilaç kullanımı, donor kaynağı (canlı, kadavra), nakil öncesi diyaliz süresi, eğitim durumu açısından fark bulunmadı (p>0.05). Renal transplant alıcılarında GÖRH sıklığı %21.7 bulunmuş olup, bu oranın genel Türk popülasyonu ile karşılaştırıldığında (%33.9) düşük, Türk hemodiyaliz hasta popülasyonu ile karşılaştırıldığında (%14) yüksek olduğu tesbit edilmiştir.

show abstract

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Cited by 12 publications

References 25 publications

Factors leading to dyspepsia in renal transplant recipients

Factors leading to dyspepsia in renal transplant recipients

Gastroduodenal Lesions in Peritoneal Dialysis Patients: The Role of Helicobacter Pylon Infection

Renal Transplant Alıcılarında Gastroözefageal Reflü Hastalığı Belirtilerinin Değerlendirilmesi

Contact Info

Product

Resources

About