Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque

Raut, Shrikant C.; Patil, Vinayak W.; Dalvi, Shubhangi M.; Bakhshi, Girish D.

doi:10.4081/cp.2015.717

Cited by 8 publications

(12 citation statements)

References 40 publications

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“…We determined in our study population with chronic gastritis that the mean of hs-CRP was 1.9±1.6 mg/dl for males and 2.2±1.9 mg/dl for females, which was higher 1 mg/dl than the normal hs-CRP level 9 . Consistent with to the studies in literature, it is found increased hs-CRP levels in parallel to the severity of HP gastritis compared to gastritis without HP infection in our study 6 , 12 . In adition, we also found that serum hs-CRP level of chronic gastritis patients with HP infection was significantly higher than those without HP infection and there was significant association between severity of HP infection and hs-CRP level.…”

Section: Discussionsupporting

confidence: 90%

“…We also found that serum hs-CRP levels have been affected by the severity of acute or chronic inflammation. Furthermore, Raut et al 6 evaluated 80 patients and found that patients with chronic gastritis and HP infection was higher hs-CRP levels than chronic gastritis patients without HP. Similarly in a study of 239 patients with chronic gastritis, Rahmani et al.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical studies and meta-analysis, eradication of HP decreases the development of gastric cancer in chronic gastritis patients with precancerous lesions such as atrophy, metaplasia, and displasia 16 , 17 . In addition to causing gastric cancer, HP gastritis has been claimed to induce endothelial dysfunction and potentially to cause cardiovascular pathologies 6 . For early diagnosis against HP and precancerous lesions, histopathological diagnosis of gastritis along with gastric cancer screening is of great importance.…”

Section: Discussionmentioning

confidence: 99%

“…Upon understanding its value in diagnosis of various conditions, high-sensitivity CRP (hs-CRP) assay has been developed to measure CRP in a sensitivity of 0.5 mg/dl 10 . In addition to being an indicator of inflammation, hs-CRP has been suggested to be a marker of cardiovascular diseases and gastric cancer in patients with HP-associated chronic gastritis 6 , 11 . Although serum level of hs-CRP has been known to increase in chronic gastritis with HP infection, limited studies have focused on the association of hs-CRP level with inflammatory activity and presence of precancerous lesions in biopsy specimens 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

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The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection

Altun¹,

Yildiz

Çevik

et al. 2019

Acta Cir. Bras.

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Purpose To evaluate serum levels of high-sensitivity C-reactive protein (hs-CRP) in chronic gastritis patients to predict Helicobacter pylori (HP) infection, inflammatory activity, and precancerous lesions. Methods A total of 811 patients with upper gastrointestinal symptoms and histopathological diagnosis of chronic gastritis were enrolled in the study. On endoscopy, five gastric biopsies were taken according to Modified Sydney protocol, which were stained with hematoxylin & eosin and Giemsa Results HP infection was found in 28.6% of patients, being significantly more common in specimens with acute and chronic inflammatory activity. Mucosal atrophy, intestinal metaplasia, and dysplasia were found in 20.2%, 18.8% and 2.7% of biopsy specimens. Mean hs-CRP was 1.9±1.6 mg/dl for males and 2.2±1.9 mg/dl for females. hs-CRP average were significantly higher in patients with severe acute inflammation (p:0.049), in patients with severe chronic inflammation (p:0.015) and in those with HP (p: 0.001) . The severity of HP infection increased significantly with the increased degree of acute inflammation, chronic inflammation and hs-CRP level (p=0.001 for both). Conclusion Serum hs-CRP level increases in patients with chronic gastritis, it could be an indicator of severity of acute or chronic mucosal inflammation, and presence of HP infection. Therefore, hs-CRP may aid the diagnosis of chronic gastritis, but it is not associated with pre-cancerous lesions.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection

Altun¹,

Yildiz

Çevik

et al. 2019

Acta Cir. Bras.

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“…The possible mechanism was reported as decreased methylation due to vitamin and folate deficiency, characteristic of chronic gastritis. The resultant increase in plasma homocysteine levels produces toxic effects in endothelial cells leading to the development of coronary artery disease [24]. However, this causal relationship was not supported by earlier clinical investigations.…”

Section: Helicobacter Pylorimentioning

confidence: 94%

A Review of the Association Between Coronary Artery Disease and Infection

Onk¹,

Kahraman²,

Aksoy³

2016

Ann Clin Anal Med

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ÖzetKoroner arter aterosklerozunun kronik inflamasyon-onarım kaskadları gibi çeşili inflamatuvar süreçlerle ilişkisi üzerinde uzun süredir durulmaktadır. İn-sanlarda ateroskleroz gelişiminde belirli inflamatuvar yolakların rolüne işa-ret eden çok sayıda kanıt mevcuttur. Bununla birlikte, enfeksiyon ile koroner arter hastalığı arasındaki nedensellik ilişkisi daha az dikkat çekmiştir. Klamidya pnömoni, helikobakter pilori, herpes simplex virüs ve sitomegalovirus gibi bazı enfeksiyöz ajanların koroner arter hastalığının gelişimi ve şiddetiy-le önemli bir ilişki içerisinde olduğu gittikçe daha sık olarak bildirilmektedir. Belirli mikroorganizmalarla enfeksiyon ve ateroskleroz arasındaki ilişkiye dair yayınlanmış olan deneysel ve otopsi çalışmalar mevcut olsa da, enfeksiyöz etiyolojinin koroner arter hastalığının gelişiminde hayati bir rol oynayıp oynamadığı henüz netlik kazanmış değildir. Günümüzdeki veriler K. Pnömoni enfeksiyonu ile ateroskleroz arasında bir nedensellik ilişkisinin varlığına işaret etmekle birlikte H. Pilori ve herpesvirus infeksiyonunun da koroner arter hastalığının progresyonu ve şiddetinden sorumlu olabileceğine dair ikna edici kanıtlar ortaya konulmuştur. Anahtar KelimelerAteroskleroz; Enfeksiyon; İnflamasyon Abstract Atherosclerotic involvement of the coronary arteries and its association with various inflammatory processes such as chronic inflammation-repair cascades have long been considered. There has been a growing body of evidence regarding the role of certain inflammatory pathways in the development of atherosclerosis in humans. The causal relationship between infection and coronary artery disease has drawn less attention. A number of infectious agents including chlamydia pneumoniae, helicobacter pylori, herpes simplex virus, and cytomegalovirus (CMV) have increasingly been reported as having significant causal relationships with the development and severity of coronary artery disease. Despite experimental and autopsy studies of the association between infection and certain microorganisms and atherosclerosis, it is still unclear whether infectious etiology plays a crucial role in the development of coronary artery disease. Current data particularly indicate the causal relationship of C. pneumoniae with atherosclerosis and there has also been convincing evidence that H. pylori and herpesviruses may be responsible for disease progression or severity.

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Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks

Gonciarz

Lechowicz

Urbaniak

et al. 2022

Sci Rep

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Helicobacter pylori (Hp) Gram-negative bacteria cause gastritis or gastric ulcers. They may be involved in the development of systemic diseases i.e. coronary heart disease (CHD). Both Hp infection and CHD are related to inflammation accompanied by C-reactive protein (CRP), tumor necrosis factor alfa (TNF-α) and homocysteine. Low density lipoprotein (LDL) and triglicerides are a classic risk factors of CHD. Infrared spectroscopy has been introduced for monitoring chronic infections or endogenous disorders using specific absorption bands for biocomponents typed as diagnostic markers. In this study we selected specific motives of infrared radiation (IR) spectra for the sera from CHD patients infected with Hp. In total 141 sera were used: 90 from patients with CHD, all Hp positive, and 51 from healthy donors, 32 Hp negative and 21 Hp positive. Hp status was evaluated by anti-Hp IgG antibodies and/or 13C urea breath testing. IR spectra were measured using FT-IR/FT-NIR Spectrum 400 spectrometer (PerkinElmer) chemometrically analyzed using artificial neural networks and they showed differences in absorption bands corresponding to triglicerides, CRP, homocysteine, LDL and TNF-α, and selected component groups between CHD patients infected with Hp vs healthy uninfected donors (96.15% accuracy). Triglicerides and CRP were the best biomarkers linking Hp infection with CHD.

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Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque

Cited by 8 publications

References 40 publications

The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection

The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection

A Review of the Association Between Coronary Artery Disease and Infection

Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks

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