Helicobacter pylori and gut hormones

Kaneko, Hiroshi; Konagaya, Toshihiro; Kusugami, Kazuo

doi:10.1007/s005350200000

Cited by 43 publications

(35 citation statements)

References 79 publications

(95 reference statements)

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“…Several studies have reported that H. pylori seropositivity was associated with different hormones [2,[8][9][10], most of which were involved in glucose metabolism directly or indirectly [11][12][13][14][15][16][17]. To our knowledge, at least three hormones supported our results, including gastrin, leptin and ghrelin.…”

Section: Discussionsupporting

confidence: 79%

The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Zhou

Liu

et al. 2017

Diabetologia

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Aims/hypothesis Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evaluate the association between H. pylori infection and risk of developing diabetes. Methods We performed a population-based prospective study, recruiting participants aged 45-74 years and without diabetes from the Chinese Multi-provincial Cohort Study in 2002, with a 10 year follow-up to investigate development of diabetes. H. pylori serostatus was determined by measuring serum H. pylori antibodies. H. pylori seropositivity was defined as the antibody concentration ≥ 10 U/ml. To examine the association between H. pylori seropositivity and diabetes risk, modified Poisson regression was performed. Results Of 2085 participants without diabetes, 1208 (57.9%) were H. pylori seropositive in 2002. After multivariate adjustment of possible diabetes risk factors, H. pylori seropositivity was associated with lower risk of diabetes (RR 0.78 [95% CI 0.63, 0.97], p = 0.022). Of the 1275 participants with H. pylori antibody measurements in both 2002 and 2007, 677 (53.1%) were persistently seropositive. A lower risk of diabetes was also observed in participants with persistent H. pylori seropositivity (RR 0.61 [95% CI 0.41, 0.93], p = 0.020), compared with those persistently seronegative. Conclusions/interpretation H. pylori seropositivity was associated with lower risk of diabetes in this prospective cohort study. Extrapolation of these results and the mechanism underlying the observed association require further investigation.

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Section: Discussionsupporting

confidence: 79%

The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Zhou

Liu

et al. 2017

Diabetologia

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“…H. pylori infection increases plasma gastrin concentrations during fasting, after meals, and after the infusion of bombesin or gastrin-releasing peptide (17 -19). SST deficiency had been proposed in duodenal ulcer patients before the discovery of H. pylori (3). Recent studies have clearly demonstrated that antral SST levels were decreased in H. pylori infection (20,21).…”

Section: Discussionmentioning

confidence: 99%

“…SST has an inhibitory effect on growth hormone (GH) release, and the presence of SST-containing D cells in the canine antral mucosa has been shown by Fujita and Kobayashi (4 (6). H. pylori infection has been shown to increase plasma gastrin concentrations during fasting and after meals (3).…”

Section: Introductionmentioning

confidence: 99%

“…Gastric acid secretion is also regulated by many factors involving the autonomic nervous system and gut hormones. Among several hormones affecting gastric acid secretion directly or indirectly, the most important regulatory peptides in the gastric mucosa include gastrin and somatostatin (SST) (3). SST has an inhibitory effect on growth hormone (GH) release, and the presence of SST-containing D cells in the canine antral mucosa has been shown by Fujita and Kobayashi (4 (6).…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori has no effect on plasma ghrelin levels

Gökçel

Gümürdülü

Kayaselçuk

et al. 2003

European Journal of Endocrinology

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Objective: Helicobacter pylori is the major etiologic agent for chronic active gastritis, and it also plays a crucial role in gastric and duodenal ulcer disease, as well as in gastric carcinoma. H. pylori infection has been shown to decrease plasma somatostatin (SST) and increase plasma gastrin concentrations. Ghrelin is a recently discovered peptide produced mostly in the stomach of rodents and humans and is secreted into the bloodstream. There is no data in the literature about the relationship between H. pylori and ghrelin. Design: Thirty-nine age-and BMI-matched H. pylori infection positive and negative women, from whom biopsy specimens were taken during gastric endoscopy, were included in the study. Methods: Total ghrelin was measured by enzyme immunoassay (EIA) in Medistek. All samples were measured in duplicate and averaged; results differing by more than 20% were re-assayed. Two biopsy specimens from antrum, corpus and fundus were obtained. Results: Fifteen of the subjects were H. pylori negative and 24 were H. pylori positive. Age, BMI, lipid profile and insulin sensitivity indices of the groups were similar. Plasma ghrelin levels ð375:92^7:10 vs 370:00^4:14 pmol=l; P . 0:05Þ of H. pylori negative and positive groups did not differ significantly. Conclusion: H. pylori has no effect on plasma ghrelin concentration.

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“…Following the H. pylori eradication, SST concentration becomes normal, and similarly gastrin goes back to its normal levels (4)(5)(6)(7)(8). SST inhibits the secretion of cholecystokinin, gastrin, secretine and glukagon.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographical Evaluation of Gallbladder Functions in Helicobacter Pylori-Positive and Negative Patients

2009

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Aim:Helicobacter pylori (H. pylori) infection is responsible for various pathologies in the stomach. It can be suggested that H. pylori may alter the effect of somatostatin on the gastrointestinal system, particularly having an effect on the D-cells in the antrum-located infections. Therefore, we planned to investigate the gallbladder functions ultrasonographically in H. pylori-positive and -negative patients.Methods: The study included 20 H. pylori-positive patients (mean age 41±3 years, 15 female and 5 male) and 22 H. pylori-negative patients (mean age 41±2 years, 16 female and 6 male) based on the mucosal biopsies from antrum, corpus and fundus in upper gastrointestinal endoscopy performed for the evaluation of dyspepsia. The gallbladder (GB) was ultrasonographically evaluated pre-and postprandially for each patient (after 8 hours fasting and oral intake of 100 gr chocolate). Four parameters demonstrating the GB functions were assessed; 1) preprandial GB volume; 2) postprandial residual volume at 2 hours; 3) postprandial residual volume at 3 hours; and 4) residual volume after maximum contraction. In addition, ejection fraction of the gallbladder was calculated from the fasting and postprandial residual volumes.Results: The gallbladder volumes for H. pylori-positive and -negative patients were as follows respectively; 16.34±2.17 ml and 22.78±3.14 ml for fasting GB volume; 8.24±1.65 ml and 12.22±1.93 ml for residual volume at 2 hours; 7.78±1.89 ml and 10.65±1.83 ml for residual volume at 3 hours; 8.55±1.47 ml and 12.131±1.98 ml for residual volume after maximum contraction; and 55.46%±4.84 and 56.25%±8.07 for GB injection fraction. No statistically significant difference was found between the two groups.Conclusion: Although the residual volumes were slightly lower in H. pylori-positive patients compared to the H. pylori-negative patients, no statistically significant difference was found between them. Consequently, it was found that H. pylori didn't alter the GB functions in our patient group.

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Helicobacter pylori and gut hormones

Cited by 43 publications

References 79 publications

The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Helicobacter pylori has no effect on plasma ghrelin levels

Ultrasonographical Evaluation of Gallbladder Functions in Helicobacter Pylori-Positive and Negative Patients

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