Helicobacter pylori and anemia with pregnancy

Nashaat, Ehab H.; Mansour, Ghada M.

doi:10.1007/s00404-013-3138-8

Cited by 17 publications

(15 citation statements)

References 24 publications

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“…Interestingly, Nashaat et al. showed that the response to iron therapy in patients with IDA and without H. pylori infection was significantly higher than in patients with active infection. In order to more thoroughly investigate the mechanisms behind this association, Azab et al.…”

Section: Hematological Diseasesmentioning

confidence: 99%

“…Similarly, a study by Hamed et al [33] found a difference between infected and noninfected patients concerning the occurrence of dyspepsia and anemia as well as a different distribution of those conditions among patients with different histologic patterns. Interestingly, Nashaat et al [34] showed that the response to iron therapy in patients with IDA and without H. pylori infection was significantly higher than in patients with active infection. In order to more thoroughly investigate the mechanisms behind this association, Azab et al [35] studied the role of hepcidin, a systemic iron homeostasis regulator, showing that H. pylori infection upregulates its serum levels, thus attenuating the response to iron therapy in children with IDA.…”

Section: Hematological Diseases Iron Deficiency Anemiamentioning

confidence: 99%

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Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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Section: Hematological Diseasesmentioning

confidence: 99%

Section: Hematological Diseases Iron Deficiency Anemiamentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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“…Moreover, a separate case-control study revealed that a significantly higher percentage of women positive for H. pylori stool antigen (HPSA) (indicative of H. pylori infection) developed preeclampsia (PE) with intrauterine growth restriction (IUGR) compared with HPSA-negative women. It is thought that H. pylori-inducediron deficiency anemia (IDA) plays a role in driving IUGR as well [13,14]. These results thus indicated possible etiopathological connections between maternal H. pylori infection and IUGR.…”

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confidence: 90%

Maternal H. pylori seropositivity is associated with gestational hypertension but irrelevant to fetal growth and development in early childhood

Lai

Sheu

et al. 2019

Preprint

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Background: Helicobacter pylori infection is known to alter growth-related hormones and cause growth faltering in young children. It is still unknown if maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine the associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods: The prospective cohort study recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined by >12 U/ml of anti- H. pylori IgG in the maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA test. The growth of eligible neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results: Of the 106 enrolled women, 25 (23.6%) were H. pylori -seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p =0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p =0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p =0.02) compared with the seronegative women. No significant impact on birth weight, childhood growth and cognitive development was found to correlate with maternal H. pylori seropositivity during pregnancy. Conclusions: Maternal H. pylori infection during pregnancy was more likely to develop GH, but not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for such H. pylori -infected mothers.

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“…Our interest in the role of maternal H. pylori in child's neurodevelopment is founded on two case–control studies, reporting that maternal H. pylori infection could play a role in neural tube defect causation by reducing folate and vitamin B12 concentrations . During pregnancy, H. pylori has been associated with micronutrient deficiencies which are relative resistant to the indicated supplementation . Fetal brain is extremely vulnerable to such micronutrients defects .…”

mentioning

confidence: 99%

“…12,13 During pregnancy, H. pylori has been associated with micronutrient deficiencies which are relative resistant to the indicated supplementation. 14,15 Fetal brain is extremely vulnerable to such micronutrients defects. 16 To the best of our knowledge, no study has examined differences in neurodevelopment between children of H. pylori seropositive vs. seronegative mothers.…”

mentioning

confidence: 99%