Helicobacter infection in hepatocellular carcinoma tissue

Abstract

Helicobacter infection exists in liver tissues of HCC patients. Helicobacter spp. infection is related with HCC, which needs further research.

Detection of Helicobacter pylori in Paraffin-Embedded Specimens from Patients with Chronic Liver Diseases, Using the Amplification Method

“…Xuan et al [29] have detected the cagA gene in only 3 of 17 (17.6%) positive samples from patients with HCC. Stalke et al [30] have identified Helicobacter species in the liver and stomach tissue of Polish patients with CLD PCR denaturing gradient gel electrophoresis and immunohistochemistry.…”

The Family Helicobacteraceae

“…This was followed by a number of other studies however the most common finding was H. pylori DNA (reviewed in Pellicano et al 2008;Tu et al 2009;Fox et al 2011) with only two instances of successful cultivation of a bacterium from a liver sample. Again these were both identified as H. pylori (Queiroz and Santos 2001;Xuan et al 2006). While a possibility, more research is required to show a causative role for helicobacters in hepatobiliary disease in humans.…”

Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases

“…Recently, a new aspect of H. pylori-associated carcinogenesis was being discussed, the role of H. pylori in hepatocarcinogenesis [4]. Several reports indicated an increased prevalence of H. pylori in HCC tissue samples and livers infected with hepatitis viruses [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] or in patients with primary biliary cirrhosis and primary sclerosing cholangitis [25,26]. Other studies, however, also show controversial results [27].…”