Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland

Abstract

Changes in Helicobacter pylori seroprevalence were studied determining IgG and IgA antibodies of 408 randomly selected adults aged 15-74 years living in Vammala, Finland in 1973 and of 504 similarly selected subjects in 1994. Seroprevalence increased by age at both time points. The age-adjusted seroprevalence rate was clearly lower in 1994 than in 1973 (31 vs. 56%, P = 0.001). Paired serum samples of 224 subjects collected in 1973 and 1994 showed that the antibody status remained unaltered in 92%; 4% seroconverted and 4% seroreverted within the 21 years. The decrease in the seroprevalence rate in the population and the persistence of individual antibody status over two decades support a difference in H. pylori infection rates among birth cohorts over time rather than continuous acquisition of new infections with advancing age. Thus the risk of helicobacter infection in Vammala, Finland has been highest in childhood and continuously decreased at least for the last five decades.

Changing prevalence ofHelicobacter pyloriinfection in the 9th district of Budapest. A retrospective endoscopic study, 1997–2012

“…A 17 év alatt észlelt 23%-os csökkenés mérsékeltebb volt, mint a betegeinknél észlelt 38,7%, de a klinika referenciacentrum, így a beteganyag különböző lehetett, a kiinduló 42%-os klinikai érték pedig alacsonyabb az azonos évben nálunk észlelt 71,3%-nál [17]. Mind a klinikai, mind saját eredményeink alapján a vizsgált időszakokban a H. pylori prevalenciája jelentősen csökkent, igazolva a fejlett álla-mokban észlelt tendenciát [1,2,3,4,5,6,7,8,9].…”

“…Conclusions: The prevalence of Helicobacter pylori infection in the 9 th district of Budapest is decreasing, especially in cohorts born in the late 1960s and 1970s, nearly 1.5 decades before the discovery of the bacterium. Orv Bár a Helicobacter pylori (H. pylori) továbbra is a világ legelterjedtebb fertőzése, az utóbbi években a fejlett országokban különböző módszerekkel (szerológia, kilégzési teszt, szövettan/tenyésztés) a prevalencia csök-kenését írták le az Egyesült Államokban [1], Ausztrá-liában [2] Dániában [3], Hollandiában [4], Angliában [5], Németországban [6], Finnországban [7], Szlovákiában [8] és a Cseh Köztársaságban [9]. Magyarországon az első epidemiológiai vizsgálatot Tamássy Klára és Simon László végezte 1995-ben, és szerológiai módszerrel 63,3%-os átlagos prevalenciát észleltek [10].…”

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

“…The infection is usually acquired during childhood, although expression of disease does not occur in most cases until adulthood. There has been evidence for both transient and persistent colonization in children [3] , while colonization of adults with H pylori almost always persists [4] . H pylori strains are genetically diverse.…”

Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan

“…The H. pylori is a urease-positive gram-negative microaerophilic bacteria in the stomach that has spread in most populations. The H. pylori remains in the mucosal layer of the stomach for decades and people under the age of ten could become infected and transfer the infection to other family members as well (14). The antibody response following H. pylori infection would remain stably with H. pyloric gastric colonization for decades or for an entire lifetime.…”

“…In compari-son, there is less possibility for children who live in rural areas of developing countries to become asthmatic (10). In the recent years, many studies have been conducted to determine the correlation between allergic reactions and infectious diseases (11)(12)(13)(14). Helicobacter pylori is a urease-positive Gram-negative microaerophilic bacteria that grows in the stomach's mucosa and stimulates the human immune system (15), which helps release bacteria and host's inflammatory mediators in the blood (16).…”