Heimia salicifolia: A phytochemical and phytopharmacologic review

Malone, Marvin H.; Rother, Ana

doi:10.1016/0378-8741(94)90080-9

Cited by 27 publications

(26 citation statements)

References 36 publications

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“…Internamente como diurética e purgante; externamente como cicatrizante; a planta toda é utilizada como repelente de insetos (Simões et al, 1986). As partes aéreas têm ampla reputação popular de atividades antisifilítica, sudorífera, antipirética, laxativa e diurética, e são relatados como úteis na preparação de banhos pós-partos e de melhora na cura de ferimentos (Malone & Rother, 1994). Caracteres morfológicos: folhas simples, opostas ou verticiladas, raro as superiores alternas, sésseis ou quase sésseis, glabras, com bordo inteiro e base cuneada (Fig.…”

Section: Heimia Salicifolia Link -Lythraceaeunclassified

“…Os quatro alcalóides mais estudados são: vertina, liofilina, litrina e nesodina. Análises clínicas preliminares indicam que vertina e litrina aplicados oralmente aparentam cessar a atividade psicodisléptica; vertina tem potenciais tranquilizante, antiinflamatório e antiespasmódico; litrina têm potencial hidrodiurético (Malone & Rother, 1994). Do extrato hidrolisado de folhas foi isolado ácido elágico, além de sitosterol e manitol em grandes quantidades.…”

Section: Heimia Salicifolia Link -Lythraceaeunclassified

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Espécies medicinais comercializadas como "quebra-pedras" em Porto Alegre, Rio Grande do Sul, Brasil

Aita¹,

Matsuura²,

Machado³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:Este trabalho visa identificar as espécies comercializadas como quebra-pedras em Porto Alegre, verificar indícios de toxicidade e estabelecer padrões morfológicos para diferenciação das mesmas. São espécies utilizadas na medicina popular principalmente para afecções nos rins e bexiga bem como diuréticas. As 16 amostras foram adquiridas de 14 comerciantes atuantes em bancas fixas ou em feiras-livres. Realizou-se uma revisão bibliográfica para levantamento de dados referentes à utilização de plantas medicinais com o nome de quebra-pedras em diferentes cidades do Rio Grande do Sul. Indícios de toxicidade, dados químicos e biológicos destas plantas foram revisados em diferentes bases de dados e em bibliografia específica. Identificaram-se sete espécies comercializadas como quebra-pedras em Porto Alegre: Euphorbia prostrata e E. serpens (Euphorbiaceae), Phyllanthus niruri e P. tenellus (Phyllanthaceae), Desmodium incanum (Fabaceae), Cunila microcephala (Lamiaceae) e Heimia salicifolia (Lythraceae). Destas, as espécies de Phyllanthus e Euphorbia são as que apresentam maior semelhança morfológica quando comercializadas secas e fragmentadas.Unitermos: Quebra-pedras, medicina popular, morfologia.ABSTRACT: "Medicinal species sold as "quebra-pedras" in Porto Alegre, Rio Grande do Sul, Brazil". The aims of this work were to identify the species sold as "quebra-pedras" in Porto Alegre, verify signs of toxicity and establish morphological patterns that help to distinguish such species. Those species are believed to be diuretic and are used in popular medicine mainly to treat kidney and bladder affections. The samples (16) were purchased from 14 sellers who work in permanent market stalls or in public marketplaces. A bibliographic revision gathered data on the use of medicinal plants called "quebra-pedras" in several cities of Rio Grande do Sul. Signs of toxicity, chemical and biological data of these plants were reviewed from different databases and specific bibliography. Seven species were identified among those sold as "quebra-pedras" in Porto Alegre: Euphorbia prostrata and E. serpens (Euphorbiaceae), Phyllanthus niruri and P. tenellus (Phyllanthaceae), Desmodium incanum (Fabaceae), Cunila microcephala (Lamiaceae) and Heimia salicifolia (Lythraceae). The greater morphological similarity when dried and fragmented plants are sold together was verified between Phyllanthus and Euphorbia.Keywords: "Quebra-pedras", popular medicine, morphology. INTRODUÇÃOCada vez mais a população brasileira busca alternativas para o tratamento de doenças. A maioria das pessoas não busca atendimento médico, consumindo produtos que podem colocar em risco sua saúde.Zuccolotto et al. (1999) verificaram a ocorrência de problemas na qualidade de produtos fitoterápicos comercializados em Porto Alegre, tais como substituição de farmacógenos, contaminações e ausência do constituinte químico principal. Ressaltam ainda que as amostras provenientes de ervateiros foram as que apresentaram o maior índice de rejeição da qualidade.Acidentes com o uso de ...

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Section: Heimia Salicifolia Link -Lythraceaeunclassified

Espécies medicinais comercializadas como "quebra-pedras" em Porto Alegre, Rio Grande do Sul, Brasil

Aita¹,

Matsuura²,

Machado³

et al. 2009

Rev. bras. farmacogn.

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“…Due to its psychotomimetic activity, native people in Central America and Mexico have used the plant for shamanic purposes (Graham, 1997). After the administration of alcohol decoction or plant juice, the subjects experiment a variety of effects such as yellow-colored vision and auditory distortion in which bells or voices sound as if they were originated in farther distances (Malone and Rother, 1994). Phytochemical analyses have shown that H. salicifolia contain biphenylquinolizidine lactone alkaloids (Malone and Rother, 1994).…”

Section: Study Speciesmentioning

confidence: 99%

“…Heimia salicifolia (H.B&K) Link & Otto (Lythraceae family) is a wild flowering shrub distributed over Mexico, Western Texas, El Salvador, Jamaica, Uruguay, and Argentina (Malone and Rother, 1994). This plant is known as sun opener (Graham, 1997).…”

Section: Study Speciesmentioning

confidence: 99%

“…In Mexico, the most common name is sinicuichi (Guzman et al, 2006). H. salicifolia has been used in folk medicine in several countries for different indications, as an emetic, haemostatic, tonic laxative, diuretic, anti-inflammatory, and to treat some syphilis symptoms (Malone and Rother, 1994;Aguilar et al, 1994). Due to its psychotomimetic activity, native people in Central America and Mexico have used the plant for shamanic purposes (Graham, 1997).…”

Section: Study Speciesmentioning

confidence: 99%

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Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Guzmán-Hernández¹,

Segura-Cobos²,

Amato³

et al. 2018

Afr. J. Pharm. Pharmacol.

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There are reports of the presence of vasodilatory alkaloids in Heimia salicifolia extracts. The action mechanisms of the potential antihypertensive effect of such alkaloids have not however, been elucidated. The objective of the present study was to corroborate the antihypertensive and vasorelaxant activities of the isolated alkaloids from H. salicifolia, and to characterize their vasorelaxant actions. A chloroform extract (HSCE) was obtained from H. salicifolia. The alkaloids were separated by thin layer chromatography, extracted from silica gel, and evaluated using spectroscopy. The alkaloid with the most potent vasorelaxant activity was identified as lythrine. The antihypertensive effect of the HSCE was corroborated on normotensive rats and on animals with N ω -nitro-L-arginine-methyl ester (L-NAME) induced hypertension. The action mechanisms of the HSCE and lythrine were studied on isolated and perfused rat mesenteric vascular bed (MVB) preparations. HSCE administration produced a concentration-dependent relaxation, but in preparations without vascular endothelium, the relaxant response to HSCE was significantly diminished. In MVB preparations with intact vascular endothelium, pre-contracted with phenylephrine or L-NAME, perfusion with lythrine produced concentrationdependent relaxation; a similar effect was produced by acetylcholine. Wortmannin (phosphatidylinositol 3-kinase inhibitor) and methylene blue (guanylate cyclase inhibitor) decreased the relaxant effect of lythrine. These data suggest that the vascular relaxation induced by alkaloids isolated from H. salicifolia is dependent on the activation of the nitric oxide/guanylate cyclase pathway.

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Lythraceae

Graham

2007

Flowering Plants · Eudicots

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Heimia salicifolia: A phytochemical and phytopharmacologic review

Cited by 27 publications

References 36 publications

Espécies medicinais comercializadas como "quebra-pedras" em Porto Alegre, Rio Grande do Sul, Brasil

Espécies medicinais comercializadas como "quebra-pedras" em Porto Alegre, Rio Grande do Sul, Brasil

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Lythraceae

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