Height is an indicator of vascular maintenance capacity in older men

Shimizu, Yūji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Maeda, Takahiro

doi:10.1111/ggi.12876

Cited by 23 publications

(29 citation statements)

References 30 publications

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“…In previous study, a significant positive correlation was reported between height and number of circulating CD34-positve cells in subjects with systolic hypertension but not in those without, independent of known cardiovascular risk factors [ 28 ]. And we also reported in previous study that the number of platelets and circulating CD34-positive cells acts as an indicator of the activity of the vicious cycle that exists between hypertension and endothelial dysfunction in elderly Japanese men [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

et al. 2017

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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Section: Discussionmentioning

confidence: 99%

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

et al. 2017

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“…Previously, we reported that height indicates the capacity of vascular repair in elderly men with hypertension [14]. We also reported a significant positive association between hemoglobin and hypertension [15], hypertension-induced vascular damage [16], and atherosclerosis [17].…”

Section: Introductionmentioning

confidence: 96%

Height indicates hematopoietic capacity in elderly Japanese men

Shimizu

Sato²,

Koyamatsu

et al. 2016

Aging

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Previously, we reported that height is an indicator of the capacity of vascular repair in elderly men, especially hypertensive men. On the other hand, hemoglobin could act as a possible biochemical index of hypertension-induced vascular damage. However, no studies have clarified the correlation between height and hematopoietic activity. We conducted a cross-sectional study of 249 men aged 65-69 undergoing a general health check-up. Reticulocyte was used to evaluate hematopoietic activity. Because hemoglobin concentration should influence hematopoietic activity, analyses stratified by hemoglobin level were performed. Independent of known cardiovascular risk factors and other hematological parameters (white blood cell count), a significant positive correlation was seen between height and reticulocytes for total subjects and subjects with a high hemoglobin concentration (≥14.5 g/dL), but not in subjects with a low hemoglobin concentration (<14.5 g/dL). The standardized parameter estimates (β) were β=0.18, p=0.003 for total subjects, β=0.28, p=0.001 for subjects with a high hemoglobin concentration, and β=0.03, p=0.717 for subjects with low hemoglobin. Independently, height is significantly positively correlated with reticulocyte in elderly Japanese men, particularly in men with a high hemoglobin concentration. These results indicate that subjects with a short stature might have lower hematopoietic capacity than those with a high stature.

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“…In the present study, although the correlation between height and platelet count is small, short stature activates vascular remodeling more strongly than tall stature for following reasons. First, height is positively associated with vascular maintenance capacity [28]. If aggressive vascular repair is evoked by serious endothelial damage, the maximum ability of vascular repair should be defined by height-subjects with a short stature would not activate vascular repair as strongly as subjects with a tall stature (ceiling effect).…”

Section: Discussionmentioning

confidence: 99%

“…Because creatinine clearance data were not available and estimated glomerular filtration rate (GFR) is not an effective tool for evaluating kidney function for a comparison of associations with various body heights [1,2,5,27,28, 32], we were not able to perform an analysis adjusted for exact renal function. However, our study showed that the association between height and platelet count remained significant even after adjustment for serum creatinine.…”

Section: Discussionmentioning

confidence: 99%

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a crosssectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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Height is an indicator of vascular maintenance capacity in older men

Cited by 23 publications

References 30 publications

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Height indicates hematopoietic capacity in elderly Japanese men

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