2016
DOI: 10.18632/aging.101061
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Previously, we reported that height is an indicator of the capacity of vascular repair in elderly men, especially hypertensive men. On the other hand, hemoglobin could act as a possible biochemical index of hypertension-induced vascular damage. However, no studies have clarified the correlation between height and hematopoietic activity. We conducted a cross-sectional study of 249 men aged 65-69 undergoing a general health check-up. Reticulocyte was used to evaluate hematopoietic activity. Because hemoglobin co… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

3
22
0

Year Published

2017
2017
2018
2018

Publication Types

Select...
1
1

Relationship

1
1

Authors

Journals

citations
Cited by 18 publications
(25 citation statements)
references
References 23 publications
(25 reference statements)
3
22
0
Order By: Relevance
“…Further investigations with a larger number of subjects with high hemoglobin and circulating CD34-positive cell data that enables us to perform circulating CD34-positive cell level-specific analysis will be necessary. In addition to these mechanisms, in our present study, we found a significant positive association between height and reticulocytes among subjects with a high hemoglobin concentration, as shown in a previous study [ 27 ]. Since endothelial activity is strongly associated with bone marrow activity [ 13 , 23 ] and reticulocytes act as an indicator of such activity, this positive association between height and reticulocytes may also partly indicate that subjects with a short stature might be at a disadvantage as a result of deficient endothelial repair.…”
Section: Discussionsupporting
confidence: 90%
See 2 more Smart Citations
“…Further investigations with a larger number of subjects with high hemoglobin and circulating CD34-positive cell data that enables us to perform circulating CD34-positive cell level-specific analysis will be necessary. In addition to these mechanisms, in our present study, we found a significant positive association between height and reticulocytes among subjects with a high hemoglobin concentration, as shown in a previous study [ 27 ]. Since endothelial activity is strongly associated with bone marrow activity [ 13 , 23 ] and reticulocytes act as an indicator of such activity, this positive association between height and reticulocytes may also partly indicate that subjects with a short stature might be at a disadvantage as a result of deficient endothelial repair.…”
Section: Discussionsupporting
confidence: 90%
“…Since short stature is associated with inflammatory disadvantages [ 5 , 6 ], this type of ceiling effect should act as a strong confounding factor on the association between height and platelet count. We also previously reported that height is positively associated with hematopoietic capacity [ 27 ], and bone marrow stroma cells differentiate into megakaryocytes that subsequently produce platelets [ 29 ]. In the present study population, reticulocytes were found to be significantly positively associated with height.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Further investigations with a larger number of subjects with high hemoglobin and circulating CD34-positive cell data that enables us to perform circulating CD34-positive cell level-specific analysis will be necessary. In addition to these mechanisms, in our present study, we found a significant positive association between height and reticulocytes among subjects with a high hemoglobin concentration, as shown in a previous study [27]. Since endothelial activity is strongly associated with bone marrow activity [13,23] and reticulocytes act as an indicator of such activity, this positive association between height and reticulocytes may also partly indicate that subjects with a short stature might be at a disadvantage as a result of deficient endothelial repair.…”
Section: Discussionsupporting
confidence: 91%
“…Because creatinine clearance data were not available and estimated glomerular filtration rate (GFR) is not an effective tool for evaluating kidney function for a comparison of associations with various body heights [1,2,5,27,28, 32], we were not able to perform an analysis adjusted for exact renal function. However, our study showed that the association between height and platelet count remained significant even after adjustment for serum creatinine.…”
Section: Discussionmentioning
confidence: 99%