Height correlates with dyslipidemia in non-overweight middle-aged Japanese men

Abstract

BackgroundOur previous study showed that height is inversely associated with the risk of stroke in middle-aged Japanese men, particularly in those with a low body mass index (BMI). Since height is regarded as a surrogate maker of childhood social and physical condition, while BMI may reflect primarily on the current physical condition, a detailed analysis of those with a lower BMI may elucidate the effects of childhood conditions. On the other hand, dyslipidemia is recognized as a prominent risk factor for cardiovascular disease. However, no studies have reported on the association between height and dyslipidemia accounting for BMI status.MethodsWe conducted a hospital-based general population cross-sectional study of 3016 Japanese men aged 30–59 years. Dyslipidemia is defined by the Japan Atherosclerosis Society (JAS) Guidelines as follows: triglycerides (TG) ≥ 150 mg/dL and/or low-density lipoprotein-cholesterol (LDL) ≥ 140 mg/dL, and/or high-density lipoprotein-cholesterol (HDL) < 40 mg/dL, and/or lipid lowering medication use.ResultsIndependent of classical cardiovascular risk factors, height was found to be inversely associated with dyslipidemia in subjects with a BMI <25 kg/m2 but not in subjects with a BMI ≥25 kg/m2. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of dyslipidemia for an increment of one standard deviation (SD) in height (5.7 cm) were 0.90 (0.82–0.99) for subjects with a BMI < 25 kg/m2 and 1.02 (0.89–1.17) for subjects with a BMI ≥ 25 kg/m2.ConclusionHeight is inversely associated with dyslipidemia in those with a BMI < 25 kg/m2 but not with a BMI ≥ 25 kg/m2.

Impact of single nucleotide polymorphism on short stature and reduced tongue pressure among community-dwelling elderly Japanese participants: a cross-sectional study

“…Our additional analysis which was limited to participants with a BMI < 25 kg/m 2 showed slightly stronger associations with regard to short stature and reduced MTP in relation to SNP rs3782886. Since an analysis limited to participants with a lower BMI might elucidate the influence of childhood circumstances (including genetic factors) [ 9 , 12 ], the additional analysis also supports the present conclusion that a genetic factor may influence the association between height and reduced MTP.…”

“…Since a previous study of community-dwelling elderly individuals reported that individuals in the lowest tertiles of tongue pressure had lower scores in the muscle function test (handgrip strength, jump height, and jump power) [ 8 ] than individuals in other tertiles, we defined reduced MTP as a tongue pressure in the lowest tertile of the study population (<26.5 kPa for men and <24.1 kPa for women). And short stature was defined as a height level at or under the 25th percentile of the study population (<158.0 cm for men and <145.0 cm for women) since these participants may have cardiovascular risk factors determined by childhood social and physical conditions (including genetic factors) [ 9 , 12 ].…”

“…On the other hand, height is regarded as a marker of childhood social and physical conditions [ 4 , 9 , 10 ]. Since BMI, which is reported to be associated with increased risk of disease [ 11 ], is largely influenced by current circumstances, studies limited to participants with lower BMI might allow elucidation of the influence of childhood circumstances (including genetic factors) by weakening the influence of current circumstances [ 9 , 12 ].…”

Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study

“…Potential limitations of this study warrant consideration. Because creatinine clearance data were not available and estimated glomerular filtration rate (GFR) is not an effective tool for evaluating kidney function for determining the latter’s associations with various body heights [4–7, 33, 34], we were not able to perform an analysis adjusted for exact renal function. However, our study showed that the association between height and circulatory CD34-positive cell remained significant even after adjustment for serum creatinine.…”

LDL cholesterol level in fifth-grade schoolchildren associates with stature

“…The relationships of cholesterol or CVD to height have not been explored in the major cohorts that study cardiovascular risk factors in children, such as Bogalusa Heart Study, Muscatine or in analyses of the National Health and Education Nutrition Examination Survey other than to note that a greater change in height predicts a larger LDL decrease over time (5)(6)(7). Shimizu et al showed lower LDL levels in taller adult Japanese males, unless the BMI was  25 kg/m 2 (8). The odds ratio of dyslipidemia (LDL > 140 mg/dl or triglycerides 150 mg/dl) fell from the first (shortest) to fourth (tallest) quartile in those under 25 kg/m 2 , but was nonsignificant for those 25 kg/m 2 .…”