LDL cholesterol level in fifth-grade schoolchildren associates with stature

Pyles, Lee A.; Lilly, Christa; Mullett, Charles J.; Polak, Emily S.; Elliott, Eloise; Neal, William A.

doi:10.1194/jlr.p078816

Cited by 10 publications

(15 citation statements)

References 17 publications

(18 reference statements)

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“…In Korea, the overall prevalence of dyslipidemia in adolescents aged 10–18 years is 21.7~25.2%; prevalence is reported to be two times higher (53.1~56.1%) in obese adolescents 9 . However, few studies have been conducted on the relationship between height and blood lipid concentrations in children and adolescents 10–15 . Specifically, there have been no studies on the association of dyslipidemia and height in Korean adolescents and adults.…”

Section: Introductionmentioning

confidence: 99%

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Song

Kim

et al. 2019

Sci Rep

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Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutrition Examination Survey from 2007 to 2015, from 37,889 individuals (aged 12–59 years). In adolescents, total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels had profound associations with height in both boys and girls, while high density lipoprotein-cholesterol (HDL-C) levels had an inverse association with height only in boys. Height was inversely associated with TC, triglycerides (TG), and LDL-C concentrations in men and women and positively correlated with HDL-C concentration in women. In boys, the odds ratios (ORs) for hypercholesterolemia, hypertriglyceridemia, hyper-LDL-cholesterolemia were higher for shorter subjects (ORs = 2.38~7.01), while only the OR of hyper-LDL-cholesterolemia was significantly higher in girls with short stature (OR = 3.12). In adults, the ORs for hypercholesterolemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were significantly higher in short subjects than in tall subjects after controlling for covariates (ORs = 1.50~2.61). Also, short men showed significantly higher ORs for hypertriglyceridemia (OR = 1.85) than tall men. Short stature was significantly associated with adverse lipid profiles in both adolescents and adults.

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Section: Introductionmentioning

confidence: 99%

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Song

Kim

et al. 2019

Sci Rep

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“…Furthermore, serum lipid levels and BMI in childhood correlate strongly with these values in middle age [43]. The correlation between short stature and elevated plasma LDL-C levels has also been observed in school children in fifth grade [11], however, we did not find an association between LDL-C and height, which may be because the study subjects with a height SDS of no more than − 2 were limited.…”

Section: Discussionmentioning

confidence: 59%

“…Endocrinologists have paid considerable attention to screening lipid profiles and have demonstrated the related factors in youths, especially in obese children, who are prone to having unfavourable lipid profiles [5–7]. Some studies have provided evidence that short stature is a risk factor associated with CHD [8, 9] and non-high-density lipoprotein (non-HDL) cholesterol levels even after adjustment for body mass index (BMI) in adults [10], and recent studies have reported that an inverse relationship between height and non-HDL cholesterol is also exists in children [11–13]. Therefore, these studies suggest the need to analyse the lipid profiles and the associated factors, especially in children and adolescents with short stature.…”

Section: Introductionmentioning

confidence: 99%

“…The LDL-C level is typically multifactorial, and it is well-established that BMI and LDL-C have a positive relationship in obese children [19–21] and non-obese children [22–24]. Children and adolescents with short stature have increased LDL-C levels [11], but this relationship has not received much attention. A prospective cohort study with 20 years of follow-up has reported that the childhood LDL-C levels are useful for predicting adult dyslipidaemia and other cardiovascular risks [25].…”

Section: Introductionmentioning

confidence: 99%

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Low-density lipoprotein cholesterol levels are associated with insulin-like growth factor-1 in short-stature children and adolescents: a cross-sectional study

et al. 2019

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Background Elevated low-density lipoprotein cholesterol (LDL-C) levels in childhood have recently been found to be the strongest predictive risk factor for coronary artery disease in adulthood. There is an increased level of LDL-C in children and adolescents with short stature. However, the underlying factors associated with increased LDL-C levels in children and adolescents with short stature are unknown. In addition, the insulin-like growth factor 1 (IGF-1) level in the short-stature population is usually below the normal reference range. The aim of this study was to investigate the relationship between IGF-1 standard deviation score (IGF-1 SDS) and LDL-C level in children and adolescents with short stature. Methods A cross-sectional study was conducted in a single centre of China, 557 short-stature children and adolescents whose height SDS was lower than − 2 SD after adjustment for age and gender were included. The related clinical and laboratory examinations, including anthropometric parameters, lipid profiles, IGF-1 levels and the levels of other cofactors, were assessed in all participants. Results The univariate analysis results showed a significant negative correlation between IGF-1 SDS and LDL-C levels ( P = 0.006). Furthermore, a nonlinear relationship was observed between IGF-1 SDS and LDL-C by smooth curve fitting after adjusting for possible confounders. A multivariate piecewise linear regression model revealed a significant negative correlation between IGF-1 SDS and LDL-C when the IGF-1 level was greater than − 2 SDS (β − 0.07, 95% CI -0.12, − 0.02; P = 0.006). However, we did not observe a significant relationship between IGF-1 SDS and LDL-C when the IGF-1 level was lower than − 2 SDS (β 0.08, 95% CI -0.02, 0.17; P = 0.119). Conclusion This study demonstrated a nonlinear relationship between IGF-1 and LDL-C independent of other potential confounding factors, suggesting that circulating IGF-1 may contribute to the regulation of LDL-C levels, thus meriting further investigation. Electronic supplementary material The online version of this article (10.1186/s12944-019-1062-z) contains supplementary material, which is available to authorized users.

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“…Several prospective large-scale studies and meta-analyses have reported that there is an inverse association between height and cardiovascular disease (CVD) risk [3][4][5][6] . Dyslipidaemia is one of the main risk factors for CVD, and there is a negative association between height and lipid pro le in children and adults [7][8][9] . Hence, it is necessary to pay attention to the lipid pro le of children with short stature, which is a risk factor for cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Association Between Serum Uric Acid and Triglycerides in Chinese Children and Adolescents With Short Stature

Chu

Zhao

Zhang

et al. 2020

Preprint

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Background: Elevated triglyceride (TG) levels are a biomarker of CVD risk. The relationship between serum uric acid (SUA) and TG in adults and obese children is well established. However, studies on children with short stature with SUA and TG are limited. Aim: The aim of this study was to examine the relationship between SUA and TG in Chinese children and adolescents with short stature.Methods: This study is a cross-sectional analysis of a cohort study. A total of 1095 children and adolescents with short stature (720 males and 375 females) were included. The related clinical characteristics, including body mass index (BMI), serum uric acid (SUA), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), were determined.Results: The univariate analysis results showed a significant positive association between SUA and TG (P < 0.001). Furthermore, a smooth curve fitting after adjusting for potential confounders was performed, and a nonlinear relationship between SUA and TG was observed. A multivariate piecewise linear regression model revealed a significant positive association between SUA and TG when the SUA level was greater than 7 mg/dL (β 0.13, 95% CI 0.05, 0.22; P = 0.002). However, we did not observe a significant relationship between SUA and TG when the SUA level was lower than 7 mg/dL (β 0.01, 95% CI -0.01, 0.04; P=0.799).Conclusion: This study described a nonlinear relationship between UA and TG in children and adolescents with short stature. When SUA rises to a certain level, there is a strong positive association between UA and TG. This finding suggests that elevated UA levels may be another risk indicator of cardiovascular disease in children and adolescents with short stature.

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LDL cholesterol level in fifth-grade schoolchildren associates with stature

Cited by 10 publications

References 17 publications

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Low-density lipoprotein cholesterol levels are associated with insulin-like growth factor-1 in short-stature children and adolescents: a cross-sectional study

Association Between Serum Uric Acid and Triglycerides in Chinese Children and Adolescents With Short Stature

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