Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes11The authors have no financial interest in any device or technique described in this article.

Mistlberger, Andrea; Liebmann, Jeffrey M.; Greenfield, David S.; Pons, Mauricio E.; Hoh, Sek-Tien; Ishikawa, Hiroshi; Ritch, Robert

doi:10.1016/s0161-6420(99)90419-0

Cited by 132 publications

(63 citation statements)

References 30 publications

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“…[9][10][11][12][13]19,20 Recently, we and Monteiro et al also reported that OCT could detect RNFL thickness reduction corresponding to band atrophy in eyes with compressive lesions at the chiasmal region. 14,21 In this study, peripapillary RNFL thickness of optic atrophy showed global reduction in all quadrantic sections consistent with previous reports on compressive optic neuropathy and traumatic optic neuropathy.…”

Section: Discussionmentioning

confidence: 73%

“…3,4 OCT has been mainly used for evaluating various types of retinal diseases, glaucoma, and optic nerve diseases. [5][6][7][8][9][10][11][12][13][14] In eyes with macular disease such as occult macular dystrophy, and various types of macular oedema, foveal thickness have shown a correlation with visual acuity, and alterations of macular thickness have been adopted in assessing progress of disease. [15][16][17][18] On the other hand, some studies remarked and demonstrated the decrease in peripapillary RNFL thickness in eyes with glaucoma, traumatic optic neuropathy, and compression optic neuropathy using OCT. [9][10][11][12][13][14]19,20 Although it has been reported that peripapillary RNFL thickness represents the severity of visual field loss and would be of clinical use, 14,21 little attention have been paid to the relationship between visual function and macular thickness in eyes with optic nerve disease.…”

Section: Introductionmentioning

confidence: 99%

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Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

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Aims To assess the changes in macular and peripapillary retinal nerve fibre layer (RNFL) thickness in eyes with unilateral optic atrophy and to evaluate the relationship between retinal thickness and visual function. Methods Enrolled were 22 patients with unilateral optic atrophy. Macular thickness at the divided nine areas and peripapillary RNFL thickness in quadrantic sections were measured by optical coherence tomography. Thickness values in the affected eyes were compared with those in the contralateral unaffected eyes. The correlation of foveal thickness with best-corrected visual acuity (BCVA) was evaluated. The correlation between retinal thickness and the remaining visual field area circumscribed with I-4-e isopter in superior and inferior hemifield was assessed.Results Macular thinning was observed in all areas (Po0.001 in each area) other than the fovea (P ¼ 0.068). Peripapillary RNFL thickness decreased in all quadrantic sections (Po0.001 in each section). The affected to unaffected eye ratio of retinal thickness was more than 0.6 in each area. BCVA did not correlate with foveal thickness (correlation coefficient ¼ 0.094, P ¼ 0.668). Although not statistically significant (P ¼ 0.281, superior hemifield; P ¼ 0.053, inferior hemifield), there was a tendency that eyes with severe visual field loss show more marked retinal thinning. Conclusions Macular thinning with the preserved foveal thickness is a hallmark of eyes with optic atrophy. Together with no correlation between foveal thickness and BCVA, this finding would help in differential diagnosis of macular and optic nerve diseases.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

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“…[18][19][20][21]23,27,29,35,36,[49][50][51][52] In our study, however, cup area was a significant predictor for OAG development only when the multivariate analysis included HRT disc area in the model. Rim and cup areas are significantly correlated with disc area in normal eyes, both in morphometric studies 44,45 and in HRT studies.…”

Section: Discussionmentioning

confidence: 83%

“…Cup shape measure has been identified from several studies as one of the most reliable stereometric HRT measurement for the early identification of glaucoma-related abnormality of the optic disc. 20,[48][49][50][51][52][53] Cup shape measure, previously known as ''third momentum,'' describes the shape of the …”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

Miglior

Zeyen

Torri

et al. 2015

American Journal of Ophthalmology

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PURPOSE: To determine whether baseline Heidelberg Retina Tomograph (HRT) measurements of the optic disc are associated with the development of open-angle glaucoma (OAG) in individuals with ocular hypertension in the European Glaucoma Prevention Study (EGPS).DESIGN: Retrospective analysis of a prospective, randomized, multicenter, double-masked, controlled clinical trial.METHODS: There were 489 participants in the HRT Ancillary Study to the EGPS. Each baseline HRT parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of OAG. Proportional hazards models were used to identify HRT variables that predicted which participants in the EGPS had developed OAG. Development of OAG was based on visual field and/or optic disc changes.RESULTS: At a median follow-up time of about 5 years, 61 participants developed OAG. In multivariate analyses, adjusting for randomization arm, age, baseline IOP, central corneal thickness, pattern standard deviation, and HRT disc area, the following HRT parameters were associated with the development of OAG: the ''outside normal limits'' classification of the Frederick Mikelberg (FSM) discriminant function (hazard ratio [HR] 2.51, 95% confidence interval [CI]: 1.45-4.35), larger mean cup depth (HR 1.64, 95% CI: 1.21-2.23), cup-to-disc area ratio (HR 1.43, 95% CI: 1.14-1.80), linear cup-to-disc ratio (HR 1.43, 95% CI: 1.13-1.80), cup area (HR 1.33, 95% CI: 1.08-1.64), smaller rim area (HR 1.33, 95% CI: 1.07-1.64), larger cup volume (HR 1.30, 95% CI: 1.05-1.61), smaller rim volume (HR 1.25, 95% CI: 1.01-1.54), larger maximum cup depth (HR 1.18, 95% CI: 1.01-1.36), and cup shape measure (HR 1.18, 95% CI: 1.01-1.36).CONCLUSIONS: Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of OAG among the EGPS participants. (Am J Ophthalmol 2015;159:265-276. Ó 2015 by Elsevier Inc. All rights reserved.)

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“…In particular, the Heidelberg Retina Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany), a confocal scanning laser tomography, has been commonly used for glaucoma diagnosis since its commercialization 20 years ago [3].…”

Section: Intruductionmentioning

confidence: 99%

A Bayesian framework for glaucoma progression detection using Heidelberg Retina Tomograph images

Belghith¹,

Bowd²,

Balasubramanian³

et al. 2013

IJACSA

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Abstract-Glaucoma, the second leading cause of blindness in the United States, is an ocular disease characterized by structural changes of the optic nerve head (ONH) and changes in visual function. Therefore, early detection is of high importance to preserve remaining visual function. In this context, the Heidelberg Retina Tomograph (HRT), a confocal scanning laser tomograph, is widely used as a research tool as well as a clinical diagnostic tool for imaging the optic nerve head to detect glaucoma and monitor its progression. In this paper, a glaucoma progression detection technique is proposed using the HRT images. Contrary to the existing methods that do not integrate the spatial pixel dependency in the change detection map, we propose the use of the Markov Random Field (MRF) to handle a such dependency. In order to estimate the model parameters, a Monte Carlo Markov Chain procedure is used. We then compared the diagnostic performance of the proposed framework to existing methods of glaucoma progression detection.

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Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes11The authors have no financial interest in any device or technique described in this article.

Cited by 132 publications

References 30 publications

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

A Bayesian framework for glaucoma progression detection using Heidelberg Retina Tomograph images

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