Hedychenone: A furanoid diterpene from Hedychium spicatum

Sharma, Shikha; Tandon, J. S.; Uprety, Hema; Shukla, Y. N.; Dhar, Mridul

doi:10.1016/0031-9422(75)85186-7

Cited by 28 publications

(14 citation statements)

References 7 publications

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“…The characteristic 21-methyl group signal was missing. The protons on Cl were shifted downfield and appeared similar to those in FX-diacetate (15) and those reported for similar lactones (16)(17)(18)(19)(20). We were unable to see the small, broadened coupling present in some, but not all, 7-lactones.…”

Section: Discussionsupporting

confidence: 57%

Fusarin C: Isolation and identification of two microsomal metabolites

Zhu

Jeffrey²

1993

Chem. Res. Toxicol.

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Fusarin C (FC), a metabolite formed by Fusarium moniliforme, is, with microsomal activation, genotoxic. Two metabolites of FC, fusarin Z (FZ) and fusarin X (FX), have been isolated from an in vitro metabolic activation system using microsomal mixtures from phenobarbital-induced rat livers and their chemical structures identified. FZ and FX are 500 and 60 times more mutagenic than FC in the Ames test, respectively. Both result from hydroxylation at the 1-position of FC. FZ is a gamma-lactone involving isomerization of the 2,3-double bond and intramolecular transesterification between the 21-methyl ester and the newly formed 1-hydroxyl group. FX, however, could not be converted to FZ by the microsomal system.

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Section: Discussionsupporting

confidence: 57%

Fusarin C: Isolation and identification of two microsomal metabolites

Zhu

Jeffrey²

1993

Chem. Res. Toxicol.

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“…The essential oil of rhizome also exhibits anthelmintic, antimicrobial and antioxidant activities (Dixit & Varma 1975;Joshi et al 2008). Previously, a variety of terpenoids (monoterpenoids, sesquiterpenoids and diterpenoids) have been reported from H. spicatum (Sharma et al 1976;Chopra et al 1980;Sharma and Tandon 1983;Joshi et al 2008;Reddy et al 2009). Considering the commercial aspects, we report in the present communication the comparative terpenoid composition and simultaneous variations of cytotoxic activity of the rhizomes essential oils of H. spicatum collected from four different regions of the western Himalaya, India.…”

Section: Introductionmentioning

confidence: 95%

Composition and in vitro cytotoxic activities of essential oil of Hedychium spicatum from different geographical regions of western Himalaya by principal components analysis

Mishra

Pal

Meena

et al. 2015

Natural Product Research

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The rhizome of Hedychium spicatum has been widely used in traditional medicines. The present study deals with the evaluation of the cytotoxic potential of rhizome essential oils from four different regions of the Western Himalaya (India) along with comparative correlation analysis to characterise the bioactive cytotoxic component. The essential oils were coded as MHS-1, MHS-2, MHS-3 and MHS-4, and characterised using GC-FID and GC-MS. The main volatile compounds identified were 1,8-cineol, eudesmol, cubenol, spathulenol and α-cadinol. In vitro cytotoxic activities were assessed against human cancer cell lines such as, the lung (A549), colon (DLD-1, SW 620), breast (MCF-7, MDA-MB-231), head and neck (FaDu), and cervix (HeLa). MHS-4 is significantly active in comparison to other samples against all cancer cell lines. Sample MHS-4 has major proportion of monoterpene alcohol mainly 1,8-cineol. Principal components analysis was performed for the experimental results and all four samples were clustered according to their percentage inhibition at different doses.

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“…The percentage inhibition of oedema volume was 64.2%, while it reduced up to 49.1% in acetyl salicylic acid in a dose of 300 mg/kg . The anti‐inflammatory activity of the species was reported to be localised mainly due to furanoid diterpene compound ‘Hedychinone’, but a similar compound 7‐hydroxy‐hedychinone did not show any activity in mice as well as in rats …”

Section: Pharmacological Studiesmentioning

confidence: 99%

“…Plethora of literature is available on chemical studies of this species (Table ). Furanoid diterpene such as hedychenone and 7‐hydroxyhedychenone was isolated from rhizome of the species, which is considered as one of the major active molecules in the species . Sharma et al .…”

Section: Phytochemical Studiesmentioning

confidence: 99%

Hedychium spicatum: a systematic review on traditional uses, phytochemistry, pharmacology and future prospectus

Rawat

Jugran

Bhatt

et al. 2018

Journal of Pharmacy and Pharmacology

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Literature reveals that the species is lacking in exact scientific basis of the beneficial properties. Although, some other distinct biological properties identified in this species also opened new door way for its new applications. Therefore, the mentioned phytochemical constituents such as phenolic and flavonoids compounds; and related pharmacological activities such as antimicrobial, anti-inflammatory and antioxidant activity of the species have provided some suggestive scientific evidences for its potential in pharmaceutical, food and aromatic industries.

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Hedychenone: A furanoid diterpene from Hedychium spicatum

Cited by 28 publications

References 7 publications

Fusarin C: Isolation and identification of two microsomal metabolites

Fusarin C: Isolation and identification of two microsomal metabolites

Composition and in vitro cytotoxic activities of essential oil of Hedychium spicatum from different geographical regions of western Himalaya by principal components analysis

Hedychium spicatum: a systematic review on traditional uses, phytochemistry, pharmacology and future prospectus

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