Hedgehog (HH) and ErbB signaling as mediators of tumor-stroma interactions in pancreatic ductal adenocarcinoma (PDAC)

Broussard, Brett L.; Mikhaylina, Alevtina; Heslin, Martin J.; Arnoletti, J. Pablo; Frolov, Andrey

doi:10.1016/j.jamcollsurg.2012.06.348

Cited by 2 publications

(2 citation statements)

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“…The mammalian TOR (MTOR) signaling pathway is reported to be related to metastasis of PDAC [55]. The ErbB signaling pathway is a mediator or has tumor stroma interactions in PDAC [56].…”

Section: Resultsmentioning

confidence: 99%

HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data

Mok

Kim

Lee

et al. 2019

Genes

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Although there have been several analyses for identifying cancer-associated pathways, based on gene expression data, most of these are based on single pathway analyses, and thus do not consider correlations between pathways. In this paper, we propose a hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE), which accounts for the hierarchical structure of genes and pathways, as well as the correlations among pathways. Specifically, HisCoM-PAGE focuses on the survival phenotype and identifies its associated pathways. Moreover, its application to real biological data analysis of pancreatic cancer data demonstrated that HisCoM-PAGE could successfully identify pathways associated with pancreatic cancer prognosis. Simulation studies comparing the performance of HisCoM-PAGE with other competing methods such as Gene Set Enrichment Analysis (GSEA), Global Test, and Wald-type Test showed HisCoM-PAGE to have the highest power to detect causal pathways in most simulation scenarios.

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“…The mammalian TOR (MTOR) signaling pathway is reported to be related to metastasis of PDAC [55]. The ErbB signaling pathway is a mediator or has tumor stroma interactions in PDAC [56].…”

Section: Resultsmentioning

confidence: 99%

HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data

Mok

Kim

Lee

et al. 2019

Genes

View full text Add to dashboard Cite

show abstract

“…The pathway named ̔Pathways in cancer̓ involves several signaling pathways, including the ErbB signaling pathway, Janus kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway, phosphoinositide 3-kinase-Akt signaling pathway, p53 signaling pathway and vascular endothelial growth factor signaling pathway. It has been demonstrated that the ErbB signaling pathway can mediate the tumor-stroma interaction in pancreatic cancer (25) and the ErbB family has been considered as the target for the treatment of human epidermal growth factor receptor in positive pancreatic cancer (26). Previous studies have indicated the abnormality of the Jak-STAT pathway in pancreatic cancer (27,28).…”

Section: Discussionmentioning

confidence: 99%

Identification of dysregulated pathways associated with pancreatic cancer by survival analysis

Yuan

Wang

et al. 2014

Molecular Medicine Reports

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In order to identify the dysregulated pathways associated with pancreatic cancer, the fourth leading cause of cancer mortality in the United States, tumor and non-tumor samples were systematically analyzed in the present study. Initially, dysregulated genes in pancreatic cancer were identified using paired t-test. Subsequently, dysregulated biological pathways involved in the development of pancreatic cancer were identified by enrichment analysis. Finally, individual survival analysis of the significantly dysregulated functions was conducted at the pathway level. Our results indicated that the pathway named ̔Pathways in cancer was significantly correlated with survival time. In addition, the mean survival time of individual and genetic variation demonstrated a significantly negative correlation, that is, the lower the genetic variation, the longer the survival time. Furthermore, detailed analysis of genes on the pathway named ̔Pathways in cancer denoted that this pathway involved multiple cancer hallmark signals and several dysregulated cancer genes, including tumor protein p53, myelocytomatosis, Kirsten rat sarcoma, phosphatidylinositol 3-kinase, v-raf murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase inhibitor 2A. According to the DrugBank database, certain oncogenes have been validated to be the targets of drugs, including Sorafenib, Trastuzumab, Imatinib and Paclitaxel or were under investigation. An improved understanding of the pathophysiology of pancreatic cancer has been achieved based on our results and the present study aimed to provide guidance for the development of drugs to treat pancreatic cancer.

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Hedgehog (HH) and ErbB signaling as mediators of tumor-stroma interactions in pancreatic ductal adenocarcinoma (PDAC)

Cited by 2 publications

References 0 publications

HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data

HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data

Identification of dysregulated pathways associated with pancreatic cancer by survival analysis

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