Identification of dysregulated pathways associated with pancreatic cancer by survival analysis

Yuan, Qiong‐Ying; Gu, Yanping; Wang, Congjun; Zhang, Hui; Wang, Xingpeng

doi:10.3892/mmr.2014.2693

Cited by 2 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Historically, the development of PDAC was attributed to DNA mutations, which are classified into three main types: oncogenes (KRAS, BRAF, AKT2, MYB, and AIBI), tumor suppressor genes (p16, CDKN2A, p53, p21, BRCA2, and SMAD4), and genome maintenance and repair genes (MLH, MSH2, and BRCA2) [1,2]. Several studies explained the complexity of genetic aberrations and their regulatory signaling pathways [3]. Although a large variety of signal transduction pathways have already been studied in PDAC, much less is known about the cross talk between epigenetic mechanism and signaling pathways typical for PDAC [1].…”

Section: Pdac From Genetics To Epigeneticsmentioning

confidence: 99%

See 1 more Smart Citation

Epigenetics: Dissecting Gene Expression Alteration in PDAC

Abukiwan¹,

Berger²

2019

DNA Repair- An Update

View full text Add to dashboard Cite

Pancreatic cancer is the fourth leading cause of cancer deaths, with a low 5-year survival rate of about 7% due to its highly invasive nature. Pancreatic ductal adenocarcinoma (PDAC) comprises more than 90% of all pancreatic cancer cases. At the time of detection, around 80% of cases harbor metastases due to the lack of early diagnosis. For decades, scientists have primarily focused on dissecting the origin of pancreatic cancer through genetic alterations and their contribution to diagnosis. Recently, PDAC research has turned into epigenetics to revolutionize our understanding about the silencing of critical regulatory genes. Epigenetic events can be divided mechanistically into various components, including DNA methylation, histone posttranslational modification, nucleosome remodeling, and regulation of transcription or translation by microRNA. The identified epigenetic processes in PDAC contribute to its specific epigenotype and are correlated phenotypic features. Strikingly, some of them have been suggested to have potential as cancer biomarkers, for disease monitoring, prognosis, and risk validation. As epigenetic aberrations are reversible, their correction will become as a promising therapeutic target.

show abstract

Section: Pdac From Genetics To Epigeneticsmentioning

confidence: 99%

“…Pancreatic ductal adenocarcinoma (PDAC) comprises more than 90% of all pancreatic cancer cases. It is highly aggressive, extremely lethal and shows resistance to chemotherapy [1][2][3]. At diagnosis, around 80% of PDAC cases have already metastasized, thus rendering the current therapeutic options practically ineffective.…”

Section: Introductionmentioning

confidence: 99%

Epigenetics: Dissecting Gene Expression Alteration in PDAC

Abukiwan¹,

Berger²

2019

DNA Repair- An Update

View full text Add to dashboard Cite

show abstract

Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas

Zeng

2017

PLoS ONE

View full text Add to dashboard Cite

Genetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. However, K-ras and p53 expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding K-ras and p53 alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome Atlas (TCGA) databases, and analyses were performed by the cBioPortal for Cancer Genomics. The mutual exclusivity analysis showed that events in K-ras and p53 were likely to co-occur in pancreatic adenocarcinoma (Log odds ratio = 1.599, P = 0.006). The graphical summary of the mutations showed that there were hotspots for protein activation. In the network analysis, no solid association between K-ras and p53 was observed in pancreatic adenocarcinoma. In the survival analysis, neither K-ras nor p53 were associated with both survival events. As in the data mining study in the TCGA databases, our study provides a new perspective to understand the genetic features of K-ras and p53 in pancreatic adenocarcinoma.

show abstract

Identification of dysregulated pathways associated with pancreatic cancer by survival analysis

Cited by 2 publications

References 37 publications

Epigenetics: Dissecting Gene Expression Alteration in PDAC

Epigenetics: Dissecting Gene Expression Alteration in PDAC

Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas

Contact Info

Product

Resources

About