Heavy-ion beam irradiation facility for biological samples in RIKEN

Radiological characteristics of MRI-based VIP polymer gel under carbon beam irradiation

“…The incident energy was taken as 127.4 AMeV (RIBF) and 287.4 AMeV (HIMAC) from the residual range of the carbon beam evaluated through ionization chamber measurements. These values are lower than the nominal extraction energy (135 and 290 AMeV) due to the energy loss during beam transportation to the incident surface, and consistent with those reported in the literature (Matsufuji et al, 2003;Ryuto et al, 2008) within the day-to-day variation. The elemental composition of VIP gel reported by Kantemiris et al (2009) was used.…”

“…The depth-dose distribution was measured as described in Kanai et al (2004). The range shifters are made of aluminum at RIKEN (Ryuto et al, 2008) and PMMA at NIRS (Minohara et al, 2010). The smallest interval is determined by the thickness of the thinnest range shifters (24 mm aluminum at RIKEN, 500 mm PMMA at HIMAC).…”

“…This carbon ion beam was spread laterally using a pair of wobbler magnets and a scatterer and had a uniform irradiation field with a diameter of approximately 8 cm and a controlled dose rate at the incident surface of about 10 Gy/min. A series of irradiation was conducted by using an automatic sample changer which automatically places each sample at the beam position (Ryuto et al, 2008). Irradiation experiments in the HIMAC-biology-beam port were conducted with a carbon beam (290 AMeV, 10 cm in diameter) spread laterally using a pair of wobbler magnets and a scatterer that had a dose rate at the incident surface of 10 Gy/min, similarly to the experiments at RIBF.…”

Mutant Resources and Mutagenomics in crop plants

“…Gamma irradiation results in small deletions (1-10 bp) while neutrons cause 300 bp to 12 kbp deletions and chemical mutagens result in point mutations mainly G/C-to-A/T transitions (Morita et al, 2009). On the other hand, ion beams have high linear energy transfer (LET) ranging from 22.5 keV μm -1 to 4000 keV μm -1 compared to 0.2 to 2 keV μm 1 LET of γ-rays and X-rays (Ryuto et al, 2008). Heavy-ion beam (HIB) irradiation is shown to be superior for mutation breeding as higher rate of mutations can be obtained at low doses (Hirano et al, 2015).…”

Plant Breeding: Past, Present and Future

“…Subsequently they were used for applied research, including mutagenesis in plant breeding since 1993 (Ryuto et al 2008). Subsequently they were used for applied research, including mutagenesis in plant breeding since 1993 (Ryuto et al 2008).…”