Heavy Charged Particle Radiotherapy

Chen, G. T. Y.; Castro, Joseph R.; Quivey, Jeanne M.

doi:10.1146/annurev.bb.10.060181.002435

Cited by 50 publications

(31 citation statements)

References 22 publications

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“…Based purely on dose localization, particle beams can maximize dose at depth; however, the degree of localization of dose with heavy ions is reduced with increasing charge on the ion, but is in all cases superior to that achievable with fast neutrons (Raju et a1., 1978a;. Current advances in computerized tomography are used to exploit this fact in treatment planning for particle therapy (Chen et al, 1981;Chen and Pitluck, 1982).…”

Section: A Depth-dose Distributionmentioning

confidence: 99%

Heavy-Ion Radiobiology: Cellular Studies

Blakely

Ngo

Curtis

et al. 1984

Advances in Radiation Biology

198

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Section: A Depth-dose Distributionmentioning

confidence: 99%

Heavy-Ion Radiobiology: Cellular Studies

Blakely

Ngo

Curtis

et al. 1984

Advances in Radiation Biology

198

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“…An isochronous Cooper-Frye (CF) [57] freeze-out procedure is employed in order to obtain the angular distribution of particles associated with the away-side jet. We use a simplified Bethe-Bloch model [58] to show that the explosive burst of energy and momentum [known as the Bragg peak [59,60,61,62]] deposited by a fully quenched jet immediately before it thermalizes does not stop the diffusion wake and, thus, no new structures in the awayside of angular correlation functions can be found. This explosive release of energy before complete stopping is a general phenomenon that has been employed, for instance, in applications of particle beams for cancer therapy [63,64,65].…”

Section: Introductionmentioning

confidence: 99%

Universality of the diffusion wake from stopped and punch-through jets in heavy-ion collisions

et al. 2009

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We solve (3+1)-dimensional ideal hydrodynamical equations with source terms that describe punch-through and fully stopped jets in order to compare their final away-side angular correlations in a static medium. For fully stopped jets, the backreaction of the medium is described by a simple Bethe-Bloch-like model which leads to an explosive burst of energy and momentum (Bragg peak) close to the end of the jet's evolution through the medium. Surprisingly enough, we find that the medium's response and the corresponding away-side angular correlations are largely insensitive to whether the jet punches through or stops inside the medium. This result is also independent of whether momentum deposition is longitudinal (as generally occurs in pQCD energy loss models) or transverse (as the Bethe-Bloch formula implies). The existence of the diffusion wake is therefore shown to be universal to all scenarios where momentum as well as energy is deposited into the medium, which can readily be understood in ideal hydrodynamics through vorticity conservation. The particle yield coming from the strong forward moving diffusion wake that is formed in the wake of both punch-through and stopped jets largely overwhelms their weak Mach cone signal after freeze-out.

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“…High LET radiations are suitable for local control of tumors because of its high relative biological effectiveness, and reduced oxygen enhancement ratio. Another advantage of heavy carbon-ion beam irradiation is its superior dose distribution (7). The sharp Bragg peak of the heavy carbon-ion beam enables the localization of energy to the target volume.…”

Section: Introductionmentioning

confidence: 99%

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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Abstract. Heavy carbon-ion beam therapy has revealed several potential advantages over X-rays. Heavy-ion therapy has been applied for various solid tumors including esophageal squamous cell carcinoma (SCC). Although the local control rate of carbon ion radiotherapy for esophageal cancer has revealed better rates than that of conventional radiotherapy, some patients have shown resistance to the treatment. No study has evaluated whether anti-cancer drugs can enhance the anti-tumor effect of heavy carbon-ion beam irradiation. Therefore, we evaluated the efficacy of docetaxel, fluorouracil, cisplatinum, doxorubicin and gemcitabine to enhance the anti-tumor effects of heavy carbon-ion beam irradiation on human esophageal SCC cells in both in vitro and in vivo experiments. Fluorouracil, cisplatinum, doxorubicin and gemcitabine showed only additive anti-tumor effects. On the other hand, growth suppression was significantly potentiated by the combined treatment with heavy carbon-ion beam and docetaxel as compared to that treated with either agent alone. These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC.

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Heavy Charged Particle Radiotherapy

Cited by 50 publications

References 22 publications

Heavy-Ion Radiobiology: Cellular Studies

Heavy-Ion Radiobiology: Cellular Studies

Universality of the diffusion wake from stopped and punch-through jets in heavy-ion collisions

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

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