Heating Preciosity—Trends in Modern Oncological Hyperthermia

Szász, Olivér; Szász, Marcell A.; Minnaar, Carrie Anne; Szász, András

doi:10.4236/ojbiphy.2017.73010

Cited by 18 publications

(18 citation statements)

References 103 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complete MAPK pathway (RAS → RAF → MEK → ERK), is also excited to the apoptotic processes [61]. The effective depth of the action does not look identical to the mathematical definition of the penetration.…”

Section: Resultsmentioning

confidence: 99%

Hyperthermia Dosing and Depth of Effect

Szász¹,

Peter²,

Vancsik³

et al. 2018

OJBIPHY

Self Cite

View full text Add to dashboard Cite

The penetration depth in the electromagnetic heating could be a crucial factor of its application, when the deep heating is the goal. The capacitive coupling is one of the most popular heating techniques in radiofrequency (RF) heating applications. The matching of the target defines the penetration possibilities. The current matched solution has deeper mathematically defined penetration in RF region than the capacitive plane-wave solution. The same power of application request high voltage with relatively low current for plane-wave inducing, while in current matching it has low voltage with high current. The effective depth of the action in the two solutions do not identical, the penetration defined by the intensity of 1/e portion of the incident beam is higher in the current-matched techniques.

show abstract

Section: Resultsmentioning

confidence: 99%

Hyperthermia Dosing and Depth of Effect

Szász¹,

Peter²,

Vancsik³

et al. 2018

OJBIPHY

Self Cite

View full text Add to dashboard Cite

show abstract

“…The similarity of the electric field and temperature actions allows the creation of the desired effects [19]. Cellular selection is performed with high preciosity, showing the excitation of the rafts of the cytoplasmic membrane well [20,21]. The selective heating of the membrane rafts affects the cytoskeleton and its polymerization too [22,23].…”

Section: Methodsmentioning

confidence: 99%

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Szász¹

2020

COR

Self Cite

View full text Add to dashboard Cite

Hyperthermia treatment for solid tumors is a long-used, but poorly accepted method in clinical use. Modulated electro-hyperthermia (mEHT, trade name: oncothermia®) changes the paradigm, introduces a novel, cellularly selective and immunogenic cell-ruination. The mEHT method produces tumor-vaccination, presenting the unharmed genetic information of cancer cells to immune cells [1]. The mEHT method is approved in more than 30 countries. Its phase II/III clinical applications indicate a broad perspective.

show abstract

“…The selection makes the high-preciosity of the energy targeting possible [47], accompanied with high efficacy as well [48]. This special energy-targeting could be one of the factors of the apoptosis induction, as well as the production of the DAMP and ICD, as a basis of tumor-vaccination [49].…”

Section: Discussionmentioning

confidence: 99%

“…One of the main objectives of modulated electro-hyperthermia (mEHT) [1] is its selective heating [2], which is supposed to be by energy-absorption of the transmembrane protein clusters (rafts) [3]. However, the measurement of the effect in nano range is highly complicated.…”

Section: Introductionmentioning

confidence: 99%

Energy Absorption by the Membrane Rafts in the Modulated Electro-Hyperthermia (mEHT)

Papp¹,

Vancsik²,

Kiss³

et al. 2017

OJBIPHY

Self Cite

View full text Add to dashboard Cite

Aim: Heating by nanoparticles, which are located in the tissue to be treated, is a well-recognized method in hyperthermic oncology. Our objective is to investigate selective, nanoscopic heating without concentrating extra artificial nanoparticles. We have in silico calculation to study the heating of the transmembrane protein clusters (rafts) on cell-membrane. The transmembrane protein domains have significantly higher dielectric constant than their lipid neighborhood in the membrane. This difference causes a local gradient in the Specific Absorption Rate (SAR), which could be a factor of heating of the membranes locally, as well as exciting the receptors for various signal transduction in the cells. We suppose that this process determines the observed cellular effects of modulated electro-hyperthermia (mEHT, trade-name: oncothermia). Materials and Methods: In silico models with highly specialized software (Computer Simulation Technology (CST), Darmstadt, Germany) were performed visualizing the selectivity for the membrane domains. Local raft models were created to simulate the electromagnetic (EM) effect of a 13.56 MHz excitation between two perfect electrical conductor plates, simulating the equipotential conditions of the sides of the membrane in the vicinity of the raft. The simulations were performed with near-field (EQS) solver of CST. The electric field, current density, and electric loss density were monitored by the simulations. The applied material properties and parameters refer to the recent literature. Results: In silico models show ten times higher energy-absorption of the transmembrane domains than that of its lipid-membrane surrounding, and intra-and extracellular neighborhood. Depending on the size, orientation, and location of the membrane rafts, the value of SAR varies, but we use only two simplified models to see the absorption properties. Taking into account the characteristics of the EM field effects we showed that the selective energy-absorption increased further by the cell-cell interactions. The The heated protein-clusters (membrane rafts) are used the same way as the artificial nanoparticles, while these absorbers are natural parts of the biological system.

show abstract

Heating Preciosity—Trends in Modern Oncological Hyperthermia

Cited by 18 publications

References 103 publications

Hyperthermia Dosing and Depth of Effect

Hyperthermia Dosing and Depth of Effect

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Energy Absorption by the Membrane Rafts in the Modulated Electro-Hyperthermia (mEHT)

Contact Info

Product

Resources

About