Heat stress attenuates free radical release in the isolated perfused rat heart

Oral Administration of Lactobacillus Induces Cardioprotection

“…Several studies have reported that during protection against myocardial ischemia, an upregulation of HSP70 levels correlates with an increase in the enzymatic activity of catalase, suggesting a link between these endogenous pathways induced by oxidative stress (Currie et al, 1988;Mocanu et al, 1993). This hypothesis is supported by the relationship between myocardial catalase activity and HSP70 expression at ischemia-reperfusion in our experiments (Oxman, 2000).…”

Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy

“…HSP70 can function as a chaperone (Yellon and Latchman 1992), improve transportation of repair proteins across cellular and subcellular membranes, prevent intracellular calcium overload, increase catalase activity (Karmazyn et al 1990;Van Why et al 1992), and reduce oxidative injury after ischemia/reperfusion (Mocanu et al 1993). Although HSPs can be induced in ischemia/reperfusion injury by ATP depletion (Van Why et al 1994), superoxide anion production (Schoeniger et al 1994), or increased cell calcium concentrations (Kiang et al 1994), the accumulated amount of HSPs may not be able to completely surmount this severe form of ischemia/reperfusion Fig.…”

“…However, hypoxic/ischemic tolerance in organs can be achieved by several types of preconditioning with sublethal stresses such as hypoxia (Bernaudin et al 2002), ischemia (Murry et al 1986;Sorimachi and Nowak 2004), and hyperthermia (Mocanu et al 1993;Marber et al 1995). The molecular mechanisms of several single preconditioning methods have been elucidated.…”

Hsp70 in myocardial ischaemia

“…For example we have found 77 that although 3-AT inhibits catalase, it paradoxically reduces (rather than potentiates) reperfusion dysrhythmias in heat stressed hearts. Similarly, Mocanu et al 63 have shown that 3-AT reduces, rather than increases free radical production in reperfused isolated rat hearts. In the same species other investigators using 3-AT have failed to abolish the enhanced post-ischaemic contractile function seen in heat stressed hearts.…”