Heat shock (stress) proteins and γδ T lymphocytes in oral lichen planus

Bramanti, Thomas E.; Dekker, Nusi P.; Lozada‐Nur, Francina; Sauk, John J.; Regezi, Joseph A.

doi:10.1016/s1079-2104(05)80254-9

Cited by 47 publications

(49 citation statements)

References 17 publications

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“…3 Positive antibody staining for heat shock proteins 27, 60, 70 and 90 was evident in all normal oral mucosal specimens (buccal, gingival and palatal). 2,4 Members of the HSP70 family are involved in the maintenance of cellular homeostasis and regulation of cell growth and transformation. 1 In this study, we examined the expression pattern of HSP70 in normal epithelial cells, oral lichen planus and non-dysplastic leucoplakias.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,8 Diverse exogenous agents may cause up-regulated expression of HSP by stressed oral keratinocytes. 3 Once the oral lichen planus lesion has developed, a variety of cytokines generated by T lymphocytes (interleukin-6, gamma-interferon and tumour necrosis factoralpha) could have up-regulated heat shock protein gene Lymphocytic infiltrate expression in the adjacent basal keratinocytes, resulting in lesion chronicity.…”

Section: Discussionmentioning

confidence: 99%

“…2 A positive expression of HSPs 60 and 70 has been demonstrated in oral lichen planus. 2,3,8 Recent studies provide both supporting and opposing evidence for the participation of HSP70 in oral lichen planus. 2,10 Previous studies have neither evaluated the expression of HSPs in oral homogeneous leucoplakia nor compared the expression of these proteins in oral lichen planus and leucoplakia.…”

Section: Expression Of Heat Shock Protein (Hsp70) In Oral Lichen Planmentioning

confidence: 99%

“…2,3,8 Recent studies provide both supporting and opposing evidence for the participation of HSP70 in oral lichen planus. 2,10 Previous studies have neither evaluated the expression of HSPs in oral homogeneous leucoplakia nor compared the expression of these proteins in oral lichen planus and leucoplakia. Accordingly, the aims of the present study have been to determine the expression of HSP70 in relation to several clinical and pathological features (tobacco use, clinical presentation and subepithelial lymphocyte in®ltrate) in oral lichen planus, and in oral non-dysplastic leucoplakia.…”

Section: Expression Of Heat Shock Protein (Hsp70) In Oral Lichen Planmentioning

confidence: 99%

“…6 HSPs are believed to have a number of cell protective functions such as assembly/disassembly of proteins, interaction with surface receptors and antigen presentation. 2,7 Overexpression of HSPs has been observed in certain cancers (breast, uterine cervix, lung, pancreas, ovary, liver, leukaemia and oral cavity). 1±4,6,8 The physiopathological activity of HSPs in tumour processes is not yet known, but it is related to cell growth and differentiation, and/or may interact with oncogenic products such as p53.…”

Section: Expression Of Heat Shock Protein (Hsp70) In Oral Lichen Planmentioning

confidence: 99%

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Expression of heat shock protein (HSP70) in oral lichen planus and non-dysplastic oral leucoplakia

et al. 2004

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The purpose of this study was to investigate the expression of heat shock protein (HSP70) in oral non-dysplastic leucoplakia and in relation to the clinical and pathological features of oral lichen planus. The expression of HSP70 was assessed in the epithelial compartment of normal mucosa (n = 5), oral lichen planus (n = 28) and benign leucoplakia (n = 11) using an immunohistochemical method. The immunostaining intensity distribution (IID) index was used to quantify the positivity of the staining. There was no association between HSP70 overexpression and clinical presentation of oral lichen planus. Oral lichen planus patients showed no statistically significant differences in the depth of the inflammatory infiltrate when expression of HSP70 was considered (X(i)- X(j) = 42.30; 95% confidence interval (95% CI) = -120.87-205.48). No statistically significant differences were identified in terms of HSP70 expression between oral lichen planus and normal buccal mucosal specimens (X(i)- X(j) = 4.07; 95% CI = -0.53-8.67). The IID index score for HSP70 expression in leucoplakia specimens was significantly higher than the one of the oral lichen planus group (X(i) - X(j)= 5.11; 95% CI = 1.73-8.48). It is concluded that there are no statistically significant differences in HSP70 expression between oral lichen planus and normal buccal mucosal specimens, suggesting that HSP70 does not play an obvious part in the pathogenesis of oral lichen planus. The expression of HSP70 was significantly higher in oral leucoplakia than in oral lichen planus, possibly because of differences in cellular activity or cell proliferation.

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