Heat Shock Proteins and Inflammation

Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.

“…The role of HSPs in infection and immunity is receiving much attention, and it has been postulated that HSP responses to stress during inflammation actually play a role in the body's defense against certain infections (15). HSPs in parasite infections appear, on the one hand, to play important roles in adaptation of microorganisms.…”

“…With regard to phagocytes, these cells protect themselves from noxious molecules that they produce, such as highly reactive oxygen metabolites. Indeed, phagocytosis and physiological activators of the oxidative burst induce HSP synthesis in macrophages (15). However, Toxoplasma parasites may survive and replicate within macrophages after phagocytosis.…”

Heat Shock Protein 72/73 in Normal and Diseased Kidneys

“…However, the specific mediators or the minimal threshold required to initiate a stress reaction are not known. Some of the known local effects of cytokines (in terleukins, tumor necrosis factors, interferons, prostaglan dins) include vasoconstriction or vasodilatation, heat pro duction, and release of oxygen radicals inducing and pro moting cellular immunologic reactions, thus injuring the cells directly or indirectly [26], Furthermore, human stress proteins have been localized immunohistochcmically with monoclonal antibodies to HSP 69 and 70 with in synovial cells, infiltrating inflammatory cells, and dis eased cartilage cells in joint tissues obtained from patients with arthritis [ 12,13]. HSP 70 was also demonstrated in normal and atherosclerotic specimens of the aorta and in plaque-associated macrophages, more so in the areas of necrosis, probably secondary to ischemia or release of cytokines [14], An interesting finding in our study is the enhanced expression of HSP only in those segments of the nephron that are surrounded by active interstitial inflammation.…”

Phagocytosis and Heat Shock Response in Human Monocytes-Macrophages

“…We then asked the question of HSP induction during phagocytosis, i.e. physiological and endogenous produc tion of OFRs, proteases, cytokines, arachidonic acid metabolites and other factors generated during phagocy tosis and inflammation [ 12], In cells of the premonocytic cell line U937, differentiated with the steroid hormone 1,25-dihydroxyvitamin D3 into a monocytic form with the ability of phagocytosing ( fig. 1) and producing OFRs, we observed that phagocytosis of IgG-coated sheep red blood cells induces the classical HSPs as well as a 32-kilodalton protein identified as heme oxygenase (HO) [20], whereas there is no modification in protein synthe sis in the undifferentiated (nonphagocytic) U937 cells ( fig.…”

“…The peculiar stressful conditions and cells on which this review will focus are those encountered by human M«p during phagocytosis and which could be extended to inflammation [12], Indeed, under these conditions, M<p are producing and facing a multiplicity of factors poten tially harmful for themselves. HSPs arc usually classified according to their respective molecu lar weight.…”