Phagocytosis and Heat Shock Response in Human Monocytes-Macrophages

Abstract

The heat shock response represents a general physiological cellular reprograming of gene expression secondary to exposure to multiple different stresses such as heat or oxygen free radicals. It is assumed that this response is turned on in order to protect cells, or to permit better recovery, from the detrimental effects of such stresses. During erythrophagocytosis, heat shock proteins and heme oxygenase synthesis are induced in human monocytes-macrophages. Whereas induction of heme oxygenase appears to be related to the hemoglobin-released iron, the factor(s) responsible for heat shock protein induction remain elusive. The respective roles of phagocytosis itself, oxygen free radicals, calcium, cytoskeletal alterations and oncogene expression are discussed.

Molecular cloning, characterization and expression of heat shock protein 90 gene in the haemocytes of bay scallop Argopecten irradians

“…Phagocytosis of bacteria or bacterial products is usually coupled with the generation of oxygen free radicals or reactive oxygen species (ROS) [49]. Generation of ROS is an effective defense against bacteria, while it is also detrimental for the host cell, which could result in protein denaturation or proteotoxicity.…”

Molecular cloning, characterization and expression analysis of heat shock protein 90 from Pacific abalone, Haliotis discus hannai Ino in response to dietary selenium

“…It has been confirmed that metabolism of heavy metals is usually coupled with the generation of oxygen free radicals or reactive oxygen species (ROS) [41,42]. Generation of excessive ROS could result in lipid oxidation and protein denaturation [5].…”

Characterization of Mitochondrial Heat Shock Protein 75 (mtHSP75) of the Big-belly Seahorse Hippocampus abdominalis

“…5B). ROS (Feuer et al, 2003;Saraste et al, 2003;Donati et al, 1991). ROS mtHSP75 (Jönsson and Schill, 2007), mtHSP75 (Gao et al, 2008).…”