Heat shock protein (hsp 70)-related epitopes are common allergenic determinants for barley and corn antigens

Proteomic Profiling Reveals New Insights into the Allergomes of Anisakis simplex, Pseudoterranova decipiens, and Contracaecum osculatum

“…The protective activity of HSPs can be one of the main mechanisms of resistance of Anisakidae larvae to low and high temperatures, which are used to kill larvae in fish products (e.g., cold smoking, freezing in domestic freezers). Furthermore, many HSPs are known as allergens (Aki et al, 1994;Chiung et al, 2000;Move´rare et al, 2000).…”

Soybean Allergens Affecting North American Patients Identified by 2D Gels and Mass Spectrometry

“…This protein was only detected by the IgE of one patient in a 2D Western blot; therefore, it is somewhat premature to speculate on its relative significance, but at this point, it does not appear to be a major allergen. However, other HSP proteins have been demonstrated to bind to human IgE from patients sensitized to penicillium (Shen et al 1997), cystic echinococcosis (Ortona et al 2003), and to corn and wheat dust (Chiung et al 2000).…”

Cross‐reactivity among fungal allergens: a clinically relevant phenomenon?

“…However, except these and perhaps some other few exceptions, the majority of the fungal allergens represent cross‐reactive structures covering different protein families. The most important basic structures showing extended cross‐reactivity derive from phylogenetically highly conserved proteins like MnSOD, 34,43 cyclophilin, 35,44 thioredoxin, 36,45 enolase, 46 heat shock proteins, 47 proteases, 48 ribosomal 49 and peroxisomal proteins 50 . Cross‐reactivity requires similarity in the three dimensional structure, not only in the strictly architectural sense, but also in the physicochemical properties such as similar charge distribution, hydrogen‐bonding potential and hydrophobicity patterns 51 .…”