Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study

Morteza, Afsaneh; Nakhjavani, Manouchehr; Larry, Mehrdada; Nargesi, Arash Aghajani; Esteghamati, Alireza

doi:10.1007/s12192-013-0435-x

Cited by 24 publications

(20 citation statements)

References 19 publications

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“…They are generally considered to be intracellular proteins with molecular chaperone functions (Hendrick and Hartl 1993). A proportion of them have been found to exist in both lesion sites and the blood stream (Zhang et al 2010;Gruden et al 2013;Morteza et al 2013). Many studies have explored the potential roles of circulating Hsps as biomarkers for diabetes and acute coronary syndrome (Morteza et al 2013;Zhang et al 2010).…”

Section: Introductionmentioning

confidence: 99%

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

Cui

Xing

Liu

et al. 2015

Cell Stress and Chaperones

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This case-control study aimed to investigate whether the levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes were associated with the risk of chronic obstructive pulmonary disease (COPD) among coal workers. A total of 76 COPD cases and 48 age-matched healthy controls from a group of coal workers were included. The case group consisted of 35 COPD patients whose condition was complicated with coal workers' pneumoconiosis (CWP) and 41 COPD patients without CWP. Heat shock proteins (Hsps) in plasma and lymphocytes were detected by ELISA and flow cytometry, respectively. Multiple logistic regression models were applied to estimate the association between Hsp levels and COPD risk. Our results showed that plasma Hsp70 and lymphocyte Hsp27 levels were significantly higher and plasma Hsp27 levels were significantly lower in COPD cases than in controls (p<0.01). No significant differences in lymphocyte Hsp70 levels were found between COPD cases and the matched subjects. Higher plasma Hsp70 levels (odds ratio (OR)=13.8, 95 % confidence interval (CI)=5.7-33.5) and lower plasma Hsp27 levels (OR=4.6, 95 % CI= 2.0-10.5) were significantly associated with an increased risk of COPD after adjusting for confounders. Higher lymphocyte Hsp27 levels were only associated with an increased risk of COPD with CWP (OR=6.6, 95 % CI=2.0-22.1) but not with an increased risk of COPD without CWP (OR=3.0, 95 % CI= 0.9-8.9). Additionally, there were strong joint effects of different Hsps on COPD risk. These results showed that higher levels of plasma Hsp70 and lower levels of plasma Hsp27 might be associated with an increased risk of COPD among coal workers. They may have the potential to serve as monitoring markers for COPD in coal workers.

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Section: Introductionmentioning

confidence: 99%

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

Cui

Xing

Liu

et al. 2015

Cell Stress and Chaperones

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“…HSP70 is a stress‐induced protein involved in protein folding, degradation, and transport . A growing number of studies demonstrate that circulating HSP70 levels are elevated in diabetes mellitus types 1 and 2 and also in GDM . It has been suggested that inflammation and oxidative stress account for the increase in serum HSP70 concentrations in these disorders.…”

Section: Resultsmentioning

confidence: 99%

Is the placental proteome impaired in well‐controlled gestational diabetes?

et al. 2019

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In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta‐specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC‐MSE approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha‐1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well controlled, did not markedly affect the placental proteome.

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“…This effect can be inhibited by HSF1 small interference RNAs, suggesting a direct regulatory effect for HSF1 on PAI-1 gene expression (Zhao and Shen 2007). Plasma level of HSPA1A is increased in patients with albuminuria (Morteza et al 2013b). In accordance, increased plasma level of PAI-1 was reported both in patients with diabetes (Hirano et al 1997) and patients with albuminuria (Stehouwer et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Extracellular levels of HSPs are increased in several diseases (Abe et al 2004;Najafizadeh et al 2015;Son et al 2015). including diabetic nephropathy (Morteza et al 2013b). Diabetic patients with albuminuria are at considerably higher risk of developing cardiovascular events (Matsushita et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria

Nargesi

Shalchi

Nargesi

et al. 2016

Cell Stress and Chaperones

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We aimed to study the relation between plasma levels of stress-induced heat shock protein 70 (HSPA1A) with plasminogen activator inhibitor-1 (PAI-1) and highdensity lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and HDL-C/Apo-A1 ratio. In a matched case-control study on patients with diabetes (40 patients with albuminuria and 40 without albuminuria matched for age, sex, and body mass index), we observed that plasma levels of HSPA1A and PAI-1 are increased in patients with albuminuria (0.55±0.02 vs. 0.77±0.04 ng/ml, p value <0.001 for HSPA1A; 25.9±2 vs. 31.8±2.4 ng/ml, p value <0.05 for PAI-1). There was a significant correlation between HSPA1A and PAI-1 in diabetic patients without albuminuria (r=0.28; p value=0.04), but not in those with albuminuria (r=0.07; p value=0.63). No association was found between HSPA1A and HDL-C, between HSPA1A and Apo-A1, or between HSPA1A and HDL-C/Apo-A1 ratio. We concluded that there is a direct correlation between plasma HSPA1A and PAI-1 levels in patients with diabetes, which is lost when they develop albuminuria.

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Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study

Cited by 24 publications

References 19 publications

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

Is the placental proteome impaired in well‐controlled gestational diabetes?

The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria

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