Heat Shock Protein 27 kDa Content in Stratum Corneum Correlates with Severity of Atopic Dermatitis

Heat shock proteins in the physiology and pathophysiology of epidermal keratinocytes

“…In turn, the pattern of HSPB1 expression was similar to healthy skin in other than above-mentioned hereditary cases of ichthyosis (Jonak et al 2005), as well as in non-cancerous skin lesions such as actinic keratosis, seborrhoeic keratosis, solar keratosis, and human papillomavirus-induced keratinocyte hyperproliferation (Trautinger et al 1995a; Gandour-Edwards et al 1994). In contrast, keratinocytes in inflammatory skin diseases such as psoriasis (Boehncke et al 1994; Choi et al 2012) and atopic dermatitis (AD) (Niiyama et al 2016) were found to contain significantly higher levels of HSPB1 than keratinocytes of healthy skin. However, no essential changes in HSPB1 expression between keratinocytes of AD and healthy skin were reported by others (Ghoreishi 2000).…”

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

“…Reflected that proteins phosphorylation play important roles in the migration of inflammatory cells and the amplification of immune responses. Heat shock proteins 27 (HSP27) can directly bind to AKT and result in increased phosphorylation of AKT and MAPK, which are required for KCs differentiation and epidermis formation ( O’Shaughnessy et al, 2007 ; Jonak et al, 2011 ); further, elevated HSP27 levels were correlated with increased severity of the AD disease severity ( Niiyama et al, 2016 ).…”

“…Local T H 1 responses tend to induce KCs apoptosis through skin-infiltrating T cells ( Grewe et al, 1998 ; Trautmann et al, 2000 ), and a correlation between T H 17 cells and T H 1 cells was found in the chronic phase of AD ( Sugaya, 2020 ). The level of T regulatory cells (Tregs) is elevated during AD pathogenesis, which could suppress responses from allergen-specific T cells and participate in multi-directional immune reactions following T H 2 and T H 17 cells ( Figure 1 ) ( O’Shaughnessy et al, 2007 ; Agrawal et al, 2011 ; Jonak et al, 2011 ; Ma et al, 2014 ; Roesner et al, 2015 ; Niiyama et al, 2016 ).…”

Serum heat shock protein 27 levels in patients with systemic sclerosis: a possible biomarker of skin sclerosis

“…7,8 In atopic dermatitis, the amount of Hsp27 in the cornified layer was correlated with the local severity score. 9 These insights suggest that Hsp27 is involved in the cutaneous response mechanism to inflammatory skin conditions, but its significance among SSc patients has not yet been elucidated.…”