Serum heat shock protein 27 levels in patients with systemic sclerosis: a possible biomarker of skin sclerosis

Matsuda, Kazuki; Yoshizaki, Ayumi; Kotani, Hirohito; Norimatsu, Yuta; Kuzumi, Ai; Fukayama, Masahisa; Fukasawa, Takemichi; Ebata, Satoshi; Yoshizaki‐Ogawa, Asako; Asano, Yoshihide; Oba, Koji; Sato, Shinichi

doi:10.1111/jdv.16885

Cited by 2 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taking into account the results of the search for biomarkers correlating with mRSS the most recent are heat shock protein 27, IgG-galactosylation ratio, and IL-16 [10,11,14]. It also appears to be very promising to study skin gene profiles of SSc patients, including epigenetics (Table 1) [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Studies regarding heat shock protein 27 (Hsp27), which serves as a pro-inflammatory signaling molecule and helps the cell to survive under conditions of stress have been conducted. In Japanese study, serum levels of Hsp27 in 67 SSc patients were investigated, it was found that the serum levels of Hsp27 correlated positively with mRSS and were notably higher in patients with dcSsc than in those with lcSSc or healthy controls [10].…”

Section: Skinmentioning

confidence: 98%

See 1 more Smart Citation

Biomarkers of Disease Activity in Systemic Sclerosis

et al. 2020

View full text Add to dashboard Cite

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and uncontrolled cutaneous and internal organs fibrosis. Diagnosis of SSc in an early phase can be difficult because of a lack of typical symptoms. The delay in diagnosis and treatment of SSc may lead to uncontrolled progression of the disease, thus identification of possible early indicators of skin and organ involvement to prevent their further damage is necessary. The aim of this study is to review the latest biomarkers of organ involvement in SSc. In patients with lung fibrosis lung-epithelial-derived surfactant protein (SP-D), the glycoprotein Krebs von den Lungen-6 (KL-6), and chemokine ligands 2, 4 and 18 (CCL2, CXCL4, CCL18) are elevated, while in patients with skin fibrosis serum levels of heat shock protein 27 (Hsp27), interleukin 16 (IL-16), and IgG–galactosylation ratio are increased. Adiponectin concentration is inversely correlated with the intensity of cutaneous fibrosis. Skin gene profiling also seems very promising. In patients with heart involvement increased serum levels of brain natriuretic peptide (BNP) are present, as well as raised Midkine and Follistatin-like 3 (FSTL3) proteins, ratios of Cu/Se and ceruloplasmin(CP) /Circulating selenoprotein P(SELENOP) and higher whole blood viscosity level. Elevated calprotectin levels are found in individuals with gastrointestinal involvement. Increased levels of chemerin and ARA autoantibodies are associated with renal involvement, whereas high levels of adhesion molecules are found in patients with scleroderma renal crisis (SRC). Currently there are no biomarkers in use that can specifically identify the early involvement of organs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Skinmentioning

confidence: 98%

Biomarkers of Disease Activity in Systemic Sclerosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this study, baseline HSP90 level in plasma was predictive of the 12-month change in DLCO (diffusing capacity for carbon monoxide) in SSc-ILD patients [46]. In addition, the expression of HSP27 also appears to be increased in the blood of SSc patients [47]. On the contrary, proteomic investigation performed in BALF from SSc patients with and without pulmonary fibrosis described a decrease in α-2 heat shock protein, specifically in patients with lung fibrosis, suggesting that individual HSPs may be differently regulated depending on specific diseases [48].…”

Section: Fibrosing Diffusementioning

confidence: 58%

Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases

Tanguy

Pommerolle

Garrido

et al. 2021

IJMS

View full text Add to dashboard Cite

Interstitial lung diseases (ILDs) include a large number of diseases and causes with variable outcomes often associated with progressive fibrosis. Although each of the individual fibrosing ILDs are rare, collectively, they affect a considerable number of patients, representing a significant burden of disease. Idiopathic pulmonary fibrosis (IPF) is the typical chronic fibrosing ILD associated with progressive decline in lung. Other fibrosing ILDs are often associated with connective tissues diseases, including rheumatoid arthritis-ILD (RA-ILD) and systemic sclerosis-associated ILD (SSc-ILD), or environmental/drug exposure. Given the vast number of progressive fibrosing ILDs and the disparities in clinical patterns and disease features, the course of these diseases is heterogeneous and cannot accurately be predicted for an individual patient. As a consequence, the discovery of novel biomarkers for these types of diseases is a major clinical challenge. Heat shock proteins (HSPs) are molecular chaperons that have been extensively described to be involved in fibrogenesis. Their extracellular forms (eHSPs) have been recently and successfully used as therapeutic targets or circulating biomarkers in cancer. The current review will describe the role of eHSPs in fibrosing ILDs, highlighting the importance of these particular stress proteins to develop new therapeutic strategies and discover potential biomarkers in these diseases.

show abstract

Serum heat shock protein 27 levels in patients with systemic sclerosis: a possible biomarker of skin sclerosis

Cited by 2 publications

References 9 publications

Biomarkers of Disease Activity in Systemic Sclerosis

Biomarkers of Disease Activity in Systemic Sclerosis

Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases

Contact Info

Product

Resources

About