Heat Shock Protein-27 Delays Acute Rejection After Cardiac Transplantation

Seemampillai, Borggia; Germack, Renée; Felkin, Leanne E.; McCormack, Ann; Rose, Marlene L.

doi:10.1097/tp.0000000000000170

Cited by 13 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, genetic overexpression of HSPs in the donor organ can alter alloimmunity in the context of experimental heart transplantation. Specifically, hearts transplanted from transgenic mice overexpressing HSP27 experienced a delayed onset of acute rejection and reduced IRI-induced apoptosis as compared with HSP27-negative hearts from littermate controls (102). A potential mechanism to explain these observations is innate immune-driven immunological memory occurring as a result of epigenetic reprogramming after stimulation.…”

Section: Implications For Damps In Sot Therapiesmentioning

confidence: 98%

Danger signals in regulating the immune response to solid organ transplantation

Todd¹,

Palmer²

2017

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Implications For Damps In Sot Therapiesmentioning

confidence: 98%

Danger signals in regulating the immune response to solid organ transplantation

Todd¹,

Palmer²

2017

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Increased levels of Hsps in transplant organ cells either by treatment or genetic manipulation have been demonstrated to be beneficial for transplant longevity ( 16 ). Hsps promote refolding of proteins denatured due to IRI, protecting cells from IRI-induced death.…”

Section: Intracellular Hsps Protect Allografts From Ischemia–reperfusmentioning

confidence: 99%

“…Hsps’ cytoprotective capacity was also demonstrated in organs that were genetically modified to overexpress these proteins. Hearts from mice overexpressing Hsp27 induction correlated with increased survival when transplanted in fully MHC-mismatched hosts ( 16 ). These hearts presented reduced caspase activation after subjection of ischemic/reperfusion conditions.…”

Section: Intracellular Hsps Protect Allografts From Ischemia–reperfusmentioning

confidence: 99%

Modulation of Alloimmunity by Heat Shock Proteins

et al. 2016

View full text Add to dashboard Cite

The immunological mechanisms that evolved for host defense against pathogens and injury are also responsible for transplant rejection. Host rejection of foreign tissue was originally thought to be mediated mainly by T cell recognition of foreign MHC alleles. Management of solid organ transplant rejection has thus focused mainly on inhibition of T cell function and matching MHC alleles between donor and host. Recently, however, it has been demonstrated that the magnitude of the initial innate immune responses upon transplantation has a decisive impact on rejection. The exact mechanisms underlying this phenomenon have yet to be characterized. Ischemic cell death and inflammation that occur upon transplantation are synonymous with extracellular release of various heat shock proteins (Hsps), many of which have been shown to have immune-modulatory properties. Here, we review the impact of Hsps upon alloimmunity and discuss the potential use of Hsps as accessory agents to improve solid organ transplant outcomes.

show abstract

“…It has also be reported that overexpression of HSP27 in mouse hearts delays the allograft rejection by inhibiting the tissue damage. Indeed, the presence of HSPs and HSP specific lymphocytes are not always indicative of a deleterious response, they might reflect an anti-inflammatory protective response also [ 45 , 46 ].…”

Section: Hsp In Transplantationmentioning

confidence: 99%

Heat shock proteins: a therapeutic target worth to consider

Dubey¹,

Prajapati²,

Swamy³

et al. 2015

Vet World

View full text Add to dashboard Cite

Heat shock proteins (HSPs) are the molecular chaperones, that are not only expressed during the normal growth process of cell cycle consecutively, but also get induced in cells during various stress conditions produced by cellular insult, environmental changes, temperature, infections, tumors etc. According to their molecular weight and functions, HSPs are divided into five major families. HSP90, HSP70, HSP60 and HSP100 are the most studied members of the family. Experimental studies have proved that overexpression and/or inhibition of HSPs play an important role in maintaining the tolerance and cell viability under above-described stress conditions. HSP90 is found to be a promising the candidate for the diagnosis, prognosis and treatment of cancer. Similarly, HSP70, HSP60 and small HSPs experimentally and clinically have potential for the treatment of neurodegenerative disease, ischemia, cell death, autoimmunity, graft rejection, etc. In a way, exploring, the cytoprotective and immunoregulatory role of HSPs can open a new avenue for the drug discovery and treatment of critical diseases.

show abstract

Heat Shock Protein-27 Delays Acute Rejection After Cardiac Transplantation

Abstract: Supplemental digital content is available in the text.

Cited by 13 publications

References 31 publications

Danger signals in regulating the immune response to solid organ transplantation

Danger signals in regulating the immune response to solid organ transplantation

Modulation of Alloimmunity by Heat Shock Proteins

Heat shock proteins: a therapeutic target worth to consider

Contact Info

Product

Resources

About