Heat shock factors and the control of the stress response

Mg, Santoro

doi:10.1016/s0006-2952(99)00299-3

Cited by 501 publications

(363 citation statements)

References 59 publications

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“…However, most of the MPSV are silent 20 They play an important role in protecting cells from any kind of stress including heat, ischemia, inflammation. Expression studies have to reveal the exact functional meaning.…”

Section: Discussionmentioning

confidence: 99%

Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations

et al. 2002

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“…In spite of their name, HSPs also respond to other stress conditions and function during normal metabolism (Santoro, 2000). Members of the Hsp90 family have been identified as playing a role in tyrosine kinase regulation.…”

Section: Heat Shockmentioning

confidence: 99%

Stress and mTORture signaling

2006

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“…Other proteomic/transcriptomic studies in bivalves point towards a common set of stress-induced proteins (Tomanek 2011). These comprise heat shock proteins (HSPs) involved in the stabilization of proteins (Clark et al 2008a;Santoro 2000), as well as molecules participating in oxidative stress regulation (Canesi et al 2010;Monari et al 2008;Park et al 2009), tissue damage repair (De Decker and Saulnier 2011;Montagnani et al 2001), tissue development (Badariotti et al 2006(Badariotti et al , 2007bTirape et al 2007), or antimicrobial defense (Xu et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Age-dependent expression of stress and antimicrobial genes in the hemocytes and siphon tissue of the Antarctic bivalve, Laternula elliptica, exposed to injury and starvation

Husmann

Abele

Rosenstiel

et al. 2014

Cell Stress and Chaperones

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Increasing temperatures and glacier melting at the Western Antarctic Peninsula (WAP) are causing rapid changes in shallow coastal and shelf systems. Climate change-related rising water temperatures, enhanced ice scouring, as well as coastal sediment runoff, in combination with changing feeding conditions and microbial community composition, will affect all elements of the nearshore benthic ecosystem, a major component of which is the Antarctic soft-shelled clam Laternula elliptica. A 454-based RNA sequencing was carried out on tissues and hemocytes of L. elliptica, resulting in 42,525 contigs, of which 48 % was assigned putative functions. Changes in the expression of putative stress response genes were then investigated in hemocytes and siphon tissue of young and old animals subjected to starvation and injury experiments in order to investigate their response to sedimentation (food dilution and starvation) and iceberg scouring (injury). Analysis of antioxidant defense (Le-SOD and Lecatalase), wound repair (Le-TIMP and Le-chitinase), and stress and immune response (Le-HSP70, Le-actin, and Letheromacin) genes revealed that most transcripts were more clearly affected by injury rather than starvation. The upregulation of these genes was particularly high in the hemocytes of young, fed individuals after acute injury. Only minor changes in expression were detected in young animals under the selected starvation conditions and in older individuals. The stress response of L. elliptica thus depends on the nature of the environmental cue and on age. This has consequences for future population predictions as the environmental changes at the WAP will differentially impact L. elliptica age classes and is bound to alter population structure.

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Heat shock factors and the control of the stress response

Cited by 501 publications

References 59 publications

Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations

Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations

Stress and mTORture signaling

Age-dependent expression of stress and antimicrobial genes in the hemocytes and siphon tissue of the Antarctic bivalve, Laternula elliptica, exposed to injury and starvation

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