Heat sensation in connection with intravenous injection of isotonic and low-osmolar X-ray contrast media and mannitol solutions

Pain in Femoral Arteriography. A double-blind, randomized, clinical study comparing safety and efficacy of the iso-osmolar iodixanol 270 mgI/ml and the low-osmolar iomeprol 300 mgI/ml in 9 European centers

“…The effects of iodixanol are qualitatively similar to the other non‐ionic LOCM, but the magnitude of the change in femoral arterial blood flow appears to be less pronounced. Several studies have shown a correlation between increased femoral arterial blood flow and osmolality of the CM, but factors other than hyper‐osmolality also contribute to the effect of CM on the vascular resistance, like viscosity, pH and chemotoxicity (2, 12, 13).…”

Pain in femoral arteriography: A double-blind, randomized, clinical study comparing safety and efficacy of the iso-osmolar iodixanol 270mgI/ml and the low-osmolar iomeprol 300 mgI/ml in 9 European centers

“…The effects of iodixanol are qualitatively similar to the other non-ionic LOCM, but the magnitude of the change in femoral arterial blood flow appears to be less pronounced. Several studies have shown a correlation between increased femoral arterial blood flow and osmolality of the CM, but factors other than hyper-osmolality also contribute to the effect of CM on the vascular resistance, like viscosity, pH and chemotoxicity (2,12,13).…”

Iodixanol in Cardioangiography

“…45 ml during 3 s. The osmolality of ioxaglate is higher than that of iodixanol, 580 mosmollkg versus 290 mosmollkg. Isotonicity is the most probable explanation for the lower intensity of discomfort being registered with iodixanol (15,19).…”

“…Non-ionic contrast media generally have an osmolality twice that of blood, while the ionic contrast medium ioxaglate 320 mg IIml has an osmolality of 580 mosmolll. Preparations of iodixanol, which is a non-ionic dimer, are formulated to be isotonic with blood (1, 19,21).…”