Heat-killed &lt;i&gt;Lactobacillus plantarum&lt;/i&gt; L-137 attenuates obesity          and associated metabolic abnormalities in C57BL/6 J mice on a high-fat          diet

Yoshitake, Rieko; Hirose, Yasuyuki; Murosaki, Shinji; Matsuzaki, Goro

doi:10.12938/bmfh.2020-040

Cited by 17 publications

(11 citation statements)

References 42 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HK L-137, a heat-treated dead bacteria has been shown to regulate intestinal microbiota and increase short-chain fatty acids in human subjects ( 39 ). Moreover, other studies reported that HK L-137 inhibits plasma lipopolysaccharide-binding protein levels, a marker of intestinal permeability, in diet-induced obese mice ( 40 ) and induces intestinal cell growth by activating intestinal function in broiler chickens ( 41 , 42 ). These suggest HK L-137 might improve intestinal barrier in a direct or indirect manner.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Heat-Killed Lactiplantibacillus plantarum L-137 on Skin Functions in Healthy Participants: A Randomized, Placebo-Controlled, Double-Blind Study

Yoshitake¹,

Nakai²,

Ebina³

et al. 2022

Front. Med.

Self Cite

View full text Add to dashboard Cite

To determine whether consuming heat-killed Lactiplantibacillus plantarum L-137 (HK L-137) influences skin functions, we performed a randomized, placebo-controlled, double-blind study in healthy participants who were conscious of dry skin. A total of 80 healthy participants (20 men, 60 women; mean age, 47.3 years) were assigned to receive a tablet containing HK L-137 or a placebo tablet daily for 12 weeks. Every 4 weeks, the skin water content and transepidermal water loss (TEWL) were measured at the forearm and face, and participants completed two skin-related questionnaires, the Dermatology Life Quality Index and a self-evaluation. The HK L-137 group tended to show greater increases from baseline of water content at the forearm and larger decreases of TEWL at the face. The total scores of both questionnaires improved significantly more in the HK L-137 group. Water content and TEWL improved significantly in participants in the HK L-137 group who were above the median age of study participants or had relatively dry skin. These findings suggest that daily HK L-137 intake can improve dry skin, thereby contributing to skin satisfaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Heat-Killed Lactiplantibacillus plantarum L-137 on Skin Functions in Healthy Participants: A Randomized, Placebo-Controlled, Double-Blind Study

Yoshitake¹,

Nakai²,

Ebina³

et al. 2022

Front. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, patients with dementia reportedly have a heavily reduced enterotype I (Bacteroides > 30%) and significantly higher F/B ratio than people without the disease (Saji et al 2019). Taking into account previous findings that oral administration of HK L-137 alleviated obesity and associated metabolic abnormalities in high-fat dietinduced obese mice (Yoshitake et al 2021), the present findings that F/B ratios decreased significantly due to HK L-137 dosing for 12 months suggest this material helps lead to an attenuation of obesity and associated metabolic disorders through improvements induced in the intestinal microbiota balance.…”

Section: Discussionmentioning

confidence: 81%

“…Apart from the effects on host immune status, HK L-137 consumption has also been shown to lead to improved hepatic inflammation status and in hepatic lipid metabolism in mice and humans; these changes are believed due, in part, to enhancements in intestinal barrier function (Tanaka et al 2020;Yoshitake et al 2021). The relationship between intestinal barrier and microbiota is complex, but recent studies showed that oral intake of heat-killed probiotics, such as Enterococcus faecalis EC-12, L. gasseri CP2305, and L. kunkeei YB38, influenced the composition of the intestinal microbiota and the intestinal environment in healthy adults (Terada et al 2004;Asama et al 2016;Sugawara et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of using heat-killed Lactobacillus plantarum L-137: High-dose and long-term use effects on immune-related safety and intestinal bacterial flora

Nakai¹,

Murosaki²,

Yamamoto³

et al. 2021

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

Heat-killed Lactobacillus plantarum L-137 (HK L-137) promotes immune function in animals. In healthy people, T-cell proliferation was shown to be enhanced by taking 10 mg HK L-137 daily for 12 weeks. However, the safety and efficacy of higher doses or longer treatments have not yet been investigated in humans. To investigate the high-dose and long-term use effects of HK L-137 on immune-related safety and on host intestinal bacterial flora, 15 healthy volunteers took a daily HK L-137 (50 mg) preparation for 4 weeks. An additional 29 participants who regularly visited a clinic for health care took HK L-137 (10 mg) daily for 12 months. Measures for anthropometrics, hematology, biochemistry, and urinalysis were taken at scheduled timepoints for all participants. Stool and blood samples were also collected and evaluated for microbes and short-chain fatty acids (SCFA); isolated T-cells were assessed for levels of proliferation induced by phytohemagglutinin in the long-term study. Adverse events or shifts in clinical measures from normal ranges due to the dietary intervention were not observed in the high-dose or long-term studies. Long-term intake also did not result in immune exhaustion due to any chronic immunostimulation; ex vivo T-cell proliferation was significantly greater at 12 months than at baseline (p < 0.01). In addition, the Firmicutes/Bacteroidetes ratio in stool samples was significantly lower at 12 months than at baseline (p < 0.05) due to the long-term intake of the HK L-137. Lastly, fecal SCFA concentrations were significantly greater (p < 0.05) at 6 months than at baseline. From these data, it can be concluded that the efficacy of HK L-137 is maintained with no overt adverse effects as a result of high-dose and/or long-term consumption.

show abstract

“…Previous study has shown that heat-killed L. plantarum L-137 strain (HK L-137) alleviated adipose tissue inflammation by inhibition of several inflammation-related genes such as F4/80, CD11c, and IL-1β. HK L-137 also decreased the level of plasma glucose, cholesterol, alanine aminotransferase (ALT), and aspartate transaminase (AST) in diet-induced obesity mice [ 32 ]. On the other hand, in the experiment using K8HK, changes in genes related to adipogenesis were observed to elicit anti-obesity mechanism.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity potential of heat-killed Lactiplantibacillus plantarum K8 in 3T3-L1 cells and high-fat diet mice

Jang

Choi²,

Choi³

et al. 2023

Heliyon

View full text Add to dashboard Cite

Heat-killed <i>Lactobacillus plantarum</i> L-137 attenuates obesity and associated metabolic abnormalities in C57BL/6 J mice on a high-fat diet

Cited by 17 publications

References 42 publications

Beneficial Effect of Heat-Killed Lactiplantibacillus plantarum L-137 on Skin Functions in Healthy Participants: A Randomized, Placebo-Controlled, Double-Blind Study

Beneficial Effect of Heat-Killed Lactiplantibacillus plantarum L-137 on Skin Functions in Healthy Participants: A Randomized, Placebo-Controlled, Double-Blind Study

Safety and efficacy of using heat-killed Lactobacillus plantarum L-137: High-dose and long-term use effects on immune-related safety and intestinal bacterial flora

Anti-obesity potential of heat-killed Lactiplantibacillus plantarum K8 in 3T3-L1 cells and high-fat diet mice

Contact Info

Product

Resources

About