Heat-Killed<i>Mycobacterium bovis</i>-Bacillus Calmette Guerin-Suppressed Total Serum IgE Response in Ovalbumin-Sensitized Newborn Mice

Bakır, Mustafa; Tükenmez, Faruk; Bahceciler, Nerin N.; Barlan, Işıl; Başaran, Müjdat

doi:10.3109/02770900009055456

Cited by 14 publications

(20 citation statements)

References 17 publications

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“…These results are in agreement with the results from other studies (30,33,36) and indicated that OVA-specific IgE, IFN-␥, IL-4, and IL-10 might not be responsible for changes of asthmatic inflammation and AHR caused by BCG and RSV interference in our mouse model.…”

Section: Discussionsupporting

confidence: 83%

“…Because a survey from Japan reported that skin test reactivity to tuberculin was shown to inversely correlate with the likelihood of having asthma (4), BCG has been studied as an anti-asthma vaccine in an attempt to verify the "hygiene hypothesis" in animals and in humans. Most of the animal studies focused on the impact of BCG on adult mice, whereas several studies used neonatal mice as a model to study heat-killed BCG by direct intranasal BCG administration (29,30). In this study, we demonstrated that live BCG inoculated in neonatal mice by subcutaneous administration was capable of suppressing the development of OVA-induced airway eosinophilia, AHR, and histologic inflammation.…”

Section: Discussionmentioning

confidence: 66%

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Respiratory Syncytial Virus Infection Reversed Anti-Asthma Effect of Neonatal Bacillus Calmette-Guerin Vaccination in BALB/c Mice

Yang

Wang

et al. 2006

Pediatr Res

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Bacillus Calmette-Guerin (BCG) vaccination can protect animals from asthma, but the effect of BCG on childhood asthma prevention is controversial in humans. To verify the hypothesis that the BCG anti-asthma effect in childhood might be reversed by a respiratory virus infection, newborn BALB/c mice were divided into five groups. Control and ovalbumin (OVA) groups were mock vaccinated and mock infected. The BCG/OVA group was BCG vaccinated and mock infected. The respiratory syncytial virus (RSV)/ OVA group was mock vaccinated and RSV infected. The BCG/RSV/ OVA group was BCG vaccinated and RSV infected. Except for the control group, all groups underwent OVA sensitization and challenge. Airway hyperresponsiveness (AHR) was measured after challenge and cells in bronchoalveolar lavage fluid (BALF) were counted. Cytokines in BALF and serum OVA-specific IgE were detected by ELISA and inflammatory characteristics of lung sections were scored. Mice with neonatal BCG vaccination (BCG/OVA group) were significantly protected from BALF eosinophilia, AHR to methacholine, peribronchiolitis, alveolitis, and peribronchial eosinophilia in comparison with the OVA, RSV/OVA, and BCG/RSV/ OVA groups. AHR in the OVA group was greater than in the BCG/OVA group but lower than in the RSV/OVA and BCG/RSV/ OVA groups. No significant differences in BALF eosinophilia, AHR, and lung inflammation were found between the RSV/OVA and BCG/RSV/OVA groups. The impact of BCG vaccination on antiasthma in mice was not dependent on interferon-␥, IL-4, and IL-10 levels. The results suggested that RSV infection can reverse the anti-asthma effect of neonatal BCG vaccination in BALB/c mice.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 66%

Respiratory Syncytial Virus Infection Reversed Anti-Asthma Effect of Neonatal Bacillus Calmette-Guerin Vaccination in BALB/c Mice

Yang

Wang

et al. 2006

Pediatr Res

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“…In addition to us, others have demonstrated a suppressive effect on various parameters of allergic inflammation in mouse models after mycobacteria pretreatment (4,5,8,9). However, except for one report from the work of Wang and Rook (7), there is no information as to the potential for these Ags in attenuating a preexisting allergic state.…”

Section: Discussionmentioning

confidence: 89%

Airway Hyperresponsiveness, Late Allergic Response, and Eosinophilia Are Reversed with Mycobacterial Antigens in Ovalbumin-Presensitized Mice

Hopfenspirger

Agrawal

2002

The Journal of Immunology

121

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Pretreatment with mycobacterial Ags has been shown to be effective in preventing allergic airway inflammation from occurring in a mouse model. Because most asthmatics are treated after the development of asthma, it is crucial to determine whether mycobacterial Ags can reverse established allergic airway inflammation in the presensitized state. Our hypothesis, based upon our previous findings, is that mycobacteria treatment in presensitized mice will suppress the allergic airway inflammation with associated clinical correlates of established asthma, with the noted exception of factors associated with the early allergic response (EAR). BALB/c mice sensitized and challenged with OVA were evaluated for pulmonary functions during both the EAR and late allergic response, and airway hyperresponsiveness to methacholine. Following this, sensitized mice were randomized and treated with placebo or a single dose (1 × 105 CFUs) of bacillus Calmette-Guérin (BCG) or Mycobacterium vaccae via nasal or peritoneal injection. One week later, the mice were rechallenged with OVA and methacholine, followed by bronchoalveolar lavage (BAL) and tissue collection. Mice treated with intranasal BCG were most significantly protected from the late allergic response (p < 0.02), airway hypersensitivity (p < 0.001) and hyperreactivity (p < 0.05) to methacholine, BAL (p < 0.05) and peribronchial (p < 0.01) eosinophilia, and BAL fluid IL-5 levels (p < 0.01) as compared with vehicle-treated, sensitized controls. Intranasal M. vaccae treatment was less effective, suppressing airway hypersensitivity (p < 0.01) and BAL eosinophilia (p < 0.05). No changes were observed in the EAR, BAL fluid IL-4 levels, or serum total and Ag-specific IgE. These data suggest that mycobacterial Ags (BCG≫M. vaccae) are effective in attenuating allergic airway inflammation and associated changes in pulmonary functions in an allergen-presensitized state.

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“…Recent studies have suggested that the Bacillus ChalmetteGuerin (BCG) vaccine may be useful as an adjuvant for the treatment of allergic diseases [23][24][25][26][27]. Yoneyama et al demonstrated that successful BCG vaccination inhibits the development of AD and asthma in children [27].…”

Section: Discussionmentioning

confidence: 99%

Specific substance of Maruyama (SSM) suppresses immune responses in atopic dermatitis-like skin lesions in DS-Nh mice by modulating dendritic cell functions

Mitsuishi

Kabashima

Tanizaki

et al. 2011

Journal of Dermatological Science

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Heat-KilledMycobacterium bovis-Bacillus Calmette Guerin-Suppressed Total Serum IgE Response in Ovalbumin-Sensitized Newborn Mice

Cited by 14 publications

References 17 publications

Respiratory Syncytial Virus Infection Reversed Anti-Asthma Effect of Neonatal Bacillus Calmette-Guerin Vaccination in BALB/c Mice

Respiratory Syncytial Virus Infection Reversed Anti-Asthma Effect of Neonatal Bacillus Calmette-Guerin Vaccination in BALB/c Mice

Airway Hyperresponsiveness, Late Allergic Response, and Eosinophilia Are Reversed with Mycobacterial Antigens in Ovalbumin-Presensitized Mice

Specific substance of Maruyama (SSM) suppresses immune responses in atopic dermatitis-like skin lesions in DS-Nh mice by modulating dendritic cell functions

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