Respiratory Syncytial Virus Infection Reversed Anti-Asthma Effect of Neonatal Bacillus Calmette-Guerin Vaccination in BALB/c Mice

Qian

Clinical and Experimental Immunology

et al. 2008

SummaryVaccination with allergen-encoding DNA has been proposed as having potential for allergen-specific immunotherapy. In this study, we examine the therapeutic effect of allergen-encoding DNA vaccination directly to dendritic cells ( + CD80 + and CD11c + CD86 + on pulmonary DCs, as compared with animals with OVA-pcDNA3·1, pcDNA3·1 and OVA respectively. DNA vaccine encoding both Fc and OVA was shown to be more effective than DNA vaccine encoding OVA alone. Our data indicate that Fc-antigen combinationencoding DNA vaccination has better preventive effects on antigen-induced airway inflammation by regulating DCs, and may be a new alternative therapy for asthma.

Section: Discussionmentioning

confidence: 68%

Potential therapy of Fc-antigen combination-encoding DNA vaccination in mouse allergic airway inflammation

Qian

Clinical and Experimental Immunology

et al. 2008

Expert Review of Respiratory Medicine

“…Further experiments on neonatal mice have confirmed that when exposed to bacteria inducing Th1 or Treg responses mice were protected from eosinophilic lung inflammation and airway hyperreactivity [64,65]. Thus suggesting the nature of early life infections determines subsequent immune responses and determines either an increased predisposition or protection from the development of allergic airways disease.…”

Section: Early Life Infections and Aberrant Immune Responsesmentioning

confidence: 94%

The need to differentiate between adults and children when treating severe asthma

Fainardi

Saglani

2015

Severe asthma at all ages is heterogeneous incorporating several phenotypes that are distinct in children and adults, however, there are also numerous similar features including the limitation that they may not remain stable longitudinally. Severe asthma in both children and adults is characterized by eosinophilic airway inflammation and evidence of airway remodeling. In adults, targeting eosinophilia with anti-IL-5 antibody therapy is very successful, resulting in the recommendation that sputum eosinophils should be used to guide treatment. In contrast, data for the efficacy of blocking IL-5 remain unavailable in children. However, its effectiveness is uncertain since many children with severe asthma have normal blood eosinophils and the dominance of Th2-mediated inflammation is controversial. Approaches that have revealed gene signatures and biomarkers such as periostin that are specific to adult disease now need to be adopted in children to identify effective pediatric specific therapeutics and minimize the extrapolation of adult therapeutics to children.

Afr. J. Microbiol. Res.

“…The airway hypersensitivity-responsiveness was measured after exhibition to BCG, and the cells in the washing fluid to bronchialveolar was counted, whose cytokines were detected by ELISA (Li et al, 2006). The control of infection is mediated by M. tuberculosis-specific CD4+ and CD8+ T cells way to the secretion of IFN- and other Th1 cytokines that activate anti-mycobacterial mechanisms of infected macrophages (Shi et al, 2003).…”

Section: T Cells (T Cells Cd4 and T Cells Cd8)mentioning

confidence: 99%

Immunity towards tuberculosis infection: A review

Aurora¹,

Luis²,

Urtiz-Estrada³

et al. 2015

Immune response represents the initial arm of host defense against Koch's bacillus. This review describes and discusses current knowledge of the host's immune response to Mycobacterium tuberculosis infection. To improve the diagnosis of tuberculosis, more rapid diagnostic techniques have been investigated in recent years, such as mediators, receptors and activators of immunity, gamma-interferon, tumor necrosis factor-alpha, reactive nitrogen intermediates, T cells, and natural killer. We consider it a first priority to implement programs of education for the development of a strategy to prevent tuberculosis. It is recommended to implement an immunotherapy treatment following chemotherapy to prevent reactivation of the bacillus due to the presence of latent bacilli in tissues.