Heat Flow Modeling for Controlled Focusing of Microwave Hyperthermia of Breast Cancer: a Computational Feasibility Study

Abstract

Heating the tumor tissue with an optimized amount of microwave energy is a promising combinational therapy, called hyperthermia treatment (HT), used with chemotherapy and radiotherapy. This combinational therapy has shown improvement in the survivorship for patients, and life after treatment. In clinical practice, radiation oncologists are still not using HT as a standard therapy because of some side effects like toxicity and hotspots on the surrounding site. To address this issue, optimal focusing of microwave on tumors, with minimal damage of surrounding tissues, is essential to avoid the side effects of HT. Our article briefly discusses on optimal focusing of microwaves on a tumor, computational feasibility study, and analysis of hyperthermia treatment. For the achievement of best outcomes, electrostatic modeling and heat flow modeling of 2D female breast models with tumors have been carried out. The finite element method (FEM) is used to solve the bio-heat equation at the tumor domain, consisting of radiation and convection-based boundary conditions. Obtained simulation results show that the highest focusing of radiation power on and around the tumor inside the breast has been given higher efficiency for hyperthermia. Our 2D modeling simulation results are helpful for improving hyperthermia treatment of breast cancer patients, with minimal damage to cells in the surrounding. Also, the article includes a mathematical analysis of hyperthermia and FEM modeling results concerning temperature distribution, heat flow, electric field intensity, electric flux density, heat flux density, and temperature variations in the breast tumor.

Advances in Finite Element Modeling of Breast Tissue Mechanics: Applications and Challenges

“…Researchers can simulate the interaction between these devices and the human body, ensuring they are safe, effective, and function as intended. This process reduces the need for extensive animal and clinical trials, accelerating the development of medical technologies [14]. Treatment Planning and Optimization: FEM is applied in treatment planning for various medical procedures, including surgery, radiation therapy, and drug delivery.…”

“…It allows healthcare providers to tailor treatments to individual patients by simulating the outcomes of different interventions. This personalized approach can improve treatment effectiveness and reduce adverse effects [14]. Drug Development and Delivery: FEM aids in drug development by modeling drug interactions with tissues and cells.…”

Numerical study of magnetic hyperthermia ablation of breast tumor on an anatomically realistic breast phantom

“…Tang et al [ 18 ] investigated the effect of injection strategy for nanofluid transport on thermal damage behavior inside biological tissue during magnetic hyperthermia. Rajput et al [ 19 ] carried out a computational feasibility study to model heat flow for a controlled focusing of microwave hyperthermia of breast cancer. Their study includes a mathematical analysis of hyperthermia and FEM modeling results.…”