Heat capacity and standard thermodynamic functions of the fullerenol C60(OH)24

Маркин, А. В.; Samosudova, Yanina S.; Ogurtsov, T. G.; Смирнова, Н. Н.; Ageev, Sergei V.; Podolsky, Nikita E.; Petrov, Andrey V.; Murin, I. V.; Semenov, Konstantin N.

doi:10.1016/j.jct.2020.106192

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…At the second step, the produced distribution of electrostatic potential was fitted with a set of point charges by means of the CHelpG algorithm. This procedure was performed for both uniform (random distribution of hydroxyl groups on the fullerene core surface) and “Saturn-like” (across the equatorial region of the fullerene core surface) isomers, the R.E.D. server was used to facilitate the task .…”

Section: Methodsmentioning

confidence: 99%

“…This adduct was obtained under mild conditions by alkaline hydrolysis of a bromo derivative C 60 Br 24 . The use of this technique made it possible to obtain a reproducible composition of the final product with a minimum content of impurity groups. ,− Thus, in this work, for the first time, a comprehensive study of the biocompatibility of the aqueous C 60 (OH) 24 solutions was carried out.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

et al. 2021

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Light fullerenes, C 60 and C 70 , have significant potential in biomedical applications due to their ability to absorb reactive oxygen species, inhibit the development of tumors, inactivate viruses and bacteria, and as the basis for developing systems for targeted drug delivery. However, the hydrophobicity of individual fullerenes complicates their practical use; therefore, creating water-soluble derivatives of fullerenes is increasingly important. Currently, the most studied soluble adducts of fullerenes are polyhydroxy fullerenes or fullerenols. Unfortunately, investigations of fullerenol biocompatibility are fragmental. They often lack reproducibility both in the synthesis of the compounds and their biological action. We here investigate the biocompatibility of a welldefined fullerenol C 60 (OH) 24 obtained using methods that minimize the content of impurities and quantitatively characterize the product's composition. We carry out comprehensive biochemical and biophysical investigations of C 60 (OH) 24 that include photodynamic properties, cyto-and genotoxicity, hemocompatibility (spontaneous and photo-induced hemolysis, platelet aggregation), and the thermodynamic characteristics of C 60 (OH) 24 binding to human serum albumin and DNA. The performed studies show good biocompatibility of fullerenol C 60 (OH) 24 , which makes it a promising object for potential use in biomedicine.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

et al. 2021

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Biologically active water-soluble fullerene adducts: Das Glasperlenspiel (by H. Hesse)?

Sharoyko

Ageev

Podolsky

et al. 2021

Journal of Molecular Liquids

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The strong interaction of actinyl ions with fullerenol driven by multiple hydrogen bonds

Jiang

2022

Dalton Trans.

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Heat capacity and standard thermodynamic functions of the fullerenol C60(OH)24

Cited by 4 publications

References 49 publications

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

Biologically active water-soluble fullerene adducts: Das Glasperlenspiel (by H. Hesse)?

The strong interaction of actinyl ions with fullerenol driven by multiple hydrogen bonds

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Heat capacity and standard thermodynamic functions of the fullerenol C60(OH)24

Cited by 4 publications

References 49 publications

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C60(OH)24: Bioactivity and Biocompatibility

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C60(OH)24: Bioactivity and Biocompatibility

Biologically active water-soluble fullerene adducts: Das Glasperlenspiel (by H. Hesse)?

The strong interaction of actinyl ions with fullerenol driven by multiple hydrogen bonds

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Product

Resources

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In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility