Biologically active water-soluble fullerene adducts: Das Glasperlenspiel (by H. Hesse)?

Sharoyko, Vladimir V.; Ageev, Sergei V.; Podolsky, Nikita E.; Petrov, Andrey V.; Litasova, Elena V.; Власов, Т. Д.; Vasina, Lubov V.; Murin, I. V.; Piotrovskiy, Levon B.; Semenov, Konstantin N.

doi:10.1016/j.molliq.2020.114990

Cited by 31 publications

(14 citation statements)

References 213 publications

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“…Some of the unique properties of fullerene are its three-dimensional structure and chemical reactivity [7][8][9][10][11][12][13][14][15]. Numerous fullerene-based compounds with different biological targets have been synthesized; biomedical and bioengineering aspects for their application are currently under intensive review [4,[16][17][18][19][20][21]. Fullerenes are prospective candidates for anticancer or antimicrobial therapy, cytoprotection, enzyme inhibition, controlled drug delivery, contrast-based or radioactivity-based diagnostic imaging, radio-protection, photosensitization, and biomimetics.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, most experimental studies did not provide proper conditions to compare biological activities of different fullerenols. Comparable conditions were provided in [25]: Eropkin et al studied biological activity of fullerenols C 60 (OH) 12-14 , C 60 (OH) [18][19][20][21][22][23][24] , and C 60 (OH) [30][31][32][33][34][35][36][37][38] . In vitro toxicity of hydroxylated fullerenes in human skin cells was assessed and explained by an increase in the number of hydroxyl groups from 20 to 32 [32].…”

Section: Introductionmentioning

confidence: 99%

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Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Kovel

Kicheeva

Vnukova

et al. 2021

IJMS

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Fullerene is a nanosized carbon structure with potential drug delivery applications. We studied the bioeffects of a water-soluble fullerene derivative, fullerenol, with 10-12 oxygen groups (F10-12); its structure was characterized by IR and XPS spectroscopy. A bioluminescent enzyme system was used to study toxic and antioxidant effects of F10-12 at the enzymatic level. Antioxidant characteristics of F10-12 were revealed in model solutions of organic and inorganic oxidizers. Low-concentration activation of bioluminescence was validated statistically in oxidizer solutions. Toxic and antioxidant characteristics of F10-12 were compared to those of homologous fullerenols with a higher number of oxygen groups:F24-28 and F40-42. No simple dependency was found between the toxic/antioxidant characteristics and the number of oxygen groups on the fullerene’s carbon cage. Lower toxicity and higher antioxidant activity of F24-28 were identified and presumptively attributed to its higher solubility. An active role of reactive oxygen species (ROS) in the bioeffects of F10-12 was demonstrated. Correlations between toxic/antioxidant characteristics of F10-12 and ROS content were evaluated. Toxic and antioxidant effects were related to the decrease in ROS content in the enzyme solutions. Our results reveal a complexity of ROS effects in the enzymatic assay system.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Kovel

Kicheeva

Vnukova

et al. 2021

IJMS

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“…The increased fullerene solubility by modifying chemical methods, such as anchoring hydroxyl or amino groups, leads to the broadly applying of C60 in the biomedical areas [85]. Naim et al (1992) [86] reported the first hydroxylated fullerene C60(OH)n afforded through the heating of C60/C70 with the excess KOH in toluene under reduced pressure.…”

Section: Fullerenementioning

confidence: 99%

Application of carbon allotropes composites for targeted cancer therapy drugs: A review

Niazvand¹,

Wagh

Khazraei

et al. 2021

jcc

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In recent years, various drug carrier nanomaterials have been investigated to improve drug delivery systems in cancer treatment. However, an ongoing requirement exists for more beneficial therapeutic materials, yielding rapid clearance, high capacity for reducing systemic toxicity via specific-tumor targeting, and superior drug solubility. Given that, carbon allotropes, including Active Carbon (AC), carbon nanotubes (CNTs), graphene and graphene oxides (GOs), nanodiamonds (NDs), fullerenes, carbon nanohorns, soporous carbons, and carbon dots, have been studied owing to their high thermal conductivity, rigid structure, flexibility for modification and functionalization, adequate surface-to-volume ratio, and high biocompatibility. This review aims to overview recent advances in applying different carbon allotrope composites in drug delivery-based cancer therapy systems.

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“…The problems were solved by modifying the surface of carbon molecules by introducing hydrophilic functional groups. The more hydrophilic groups, the greater the solubility of the molecule in aqueous solutions [ 11 , 12 , 13 ]. These modifications, apart from ensuring better solubility, also reduce the toxicity of carbon nanoparticles [ 14 , 15 , 16 ].…”

Section: Characteristics Of Fullerenes Nanotubes and Nanodiamondsmentioning

confidence: 99%

Application of Carbon Nanoparticles in Oncology and Regenerative Medicine

Lisik

Krokosz

2021

IJMS

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Currently, carbon nanoparticles play a large role as carriers of various types of drugs, and also have applications in other fields of medicine, e.g., in tissue engineering, where they are used to reconstruct bone tissue. They also contribute to the early detection of cancer cells, and can act as markers in imaging diagnostics. Their antibacterial and anti-inflammatory properties are also known. This feature is particularly important in dental implantology, where various types of bacterial infections and implant rejection often occur. The search for newer and more effective treatments may lead to future use of nanoparticles on a large scale. In this work, the current state of knowledge on the possible use of nanotubes, nanodiamonds, and fullerenes in therapy is reviewed. Both advantages and disadvantages of the use of carbon nanoparticles in therapy and diagnostics have been indicated.

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Biologically active water-soluble fullerene adducts: Das Glasperlenspiel (by H. Hesse)?

Cited by 31 publications

References 213 publications

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents

Application of carbon allotropes composites for targeted cancer therapy drugs: A review

Application of Carbon Nanoparticles in Oncology and Regenerative Medicine

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