Heartbreakers or Healers? Innate Lymphoid Cells in Cardiovascular Disease and Obesity

Abstract

Cardiovascular diseases (CVDs) are responsible for most pre-mature deaths worldwide, contributing significantly to the global burden of disease and its associated costs to individuals and healthcare systems. Obesity and associated metabolic inflammation underlie development of several major health conditions which act as direct risk factors for development of CVDs. Immune system responses contribute greatly to CVD development and progression, as well as disease resolution. Innate lymphoid cells (ILCs) are a family of helper-like and cytotoxic lymphocytes, typically enriched at barrier sites such as the skin, lung, and gastrointestinal tract. However, recent studies indicate that most solid organs and tissues are home to resident populations of ILCs - including those of the cardiovascular system. Despite their relative rarity, ILCs contribute to many important biological effects during health, whilst promoting inflammatory responses during tissue damage and disease. This mini review will discuss the evidence for pathological and protective roles of ILCs in CVD, and its associated risk factor, obesity.

Immune and inflammatory mechanisms of abdominal aortic aneurysm

“…ILC3 are RORγt-dependent cells, which produce IL-17A and IL-22 cytokines ( 130 ). The role of these cells in CVD only recently attracted attention and was discussed elsewhere ( 131 ), while their role in AAA have not yet been examined.…”