Heart Transplantation in Rats

Konertz, W; Semik, M; Bernhard, A

doi:10.1007/978-3-642-61657-0_4

Cited by 2 publications

(1 citation statement)

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“…However, since the small bowel was transplanted into a heterotopic position in this early model, the results did not reflect a physiological stage because the small bowel allograft was not part of the nutritional transit. The aim of the present study therefore was (1) to investigate small bowel transplantation in a model more closely addressing clinical needs, (2) to reduce the necessary immunosuppressive therapy, and (3) to analyze possible immunological mechanisms without interference from this immunosuppression.…”

Section: Microsurgery 21:156-162 2001mentioning

confidence: 99%

Orthotopic liver/small bowel transplantation in rats: A microsurgical model inducing tolerance

et al. 2001

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Liver cirrhosis in patients with short bowel syndrome is successfully treated in humans by simultaneous liver/small bowel transplantation. However, until now, a clinically relevant experimental rat model for this procedure has not existed. We therefore established a protocol that, for the first time in rats, allows the simultaneous transplantation of arterialized liver and small bowel into an orthotopic position. Short-term immunosuppression induced not only allograft acceptance but tolerance (as demonstrated by indicator heart/skin transplantation). The immunosuppressive dose required to achieve this result was dramatically less than that of protocols for successful small bowel transplantation alone. Immunohistochemistry detected a transient rejection crisis before tolerance. During this crisis, apoptotic recipient-type T lymphocytes, mainly CD8+ cells, accumulated in the liver but not in the small bowel allograft. The initiation of T-cell apoptosis is one possible explanation for the specific immunosuppressive effect of the liver allograft, which also supports the simultaneously transplanted small bowel allograft in our model.

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Section: Microsurgery 21:156-162 2001mentioning

confidence: 99%