Heart Transplantation From Donation After Circulatory Death Donors

Macdonald, Peter S.; Verran, Deborah; O’Leary, Michael J.; Cavazzoni, Elena; Dhital, K.

doi:10.1097/tp.0000000000000791

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…[1][2][3] In the Netherlands, already more than half of all postmortal donors are from cDCD. cDCD is increasingly becoming a major source to ease the shortage of donor organs such as kidney, lungs, pancreas, liver, and even the heart.…”

Section: Introductionmentioning

confidence: 99%

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External validation of prediction models for time to death in potential donors after circulatory death

Kotsopoulos

Böing-Messing

Jansen³

et al. 2018

American Journal of Transplantation

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Predicting time to death in controlled donation after circulatory death (cDCD) donors following withdrawal of life‐sustaining treatment (WLST) is important but poses a major challenge. The aim of this study is to determine factors predicting time to circulatory death within 60 minutes after WSLT and validate previously developed prediction models. In a single‐center retrospective study, we used the data of 92 potential cDCD donors. Multivariable regression analysis demonstrated that absent cough‐, corneal reflex, lower morphine dosage, and midazolam use were significantly associated with death within 60 minutes (area under the curve [AUC] 0.89; 95% confidenence interval [CI] 0.87‐0.91). External validation of the logistic regression models of de Groot et al (AUC 0.86; 95% CI 0.77‐0.95), Wind et al (AUC 0.62; 95% CI 0.49‐0.76), Davila et al (AUC 0.80; 95% CI 0.708‐0.901) and the Cox regression model by Suntharalingam et al (Harrell's c‐index 0.63), exhibited good discrimination and could fairly identify which patients died within 60 minutes. Previous prediction models did not incorporate the process of WLST. We believe that future studies should also include the process of WLST as an important predictor.

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Section: Introductionmentioning

confidence: 99%

“…cDCD is increasingly becoming a major source to ease the shortage of donor organs such as kidney, lungs, pancreas, liver, and even the heart. [1][2][3] In the Netherlands, already more than half of all postmortal donors are from cDCD.…”

Section: Introductionmentioning

confidence: 99%

External validation of prediction models for time to death in potential donors after circulatory death

Kotsopoulos

Böing-Messing

Jansen³

et al. 2018

American Journal of Transplantation

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“…St Vincent's Hospital, Sydney first reported a successful method to use DCD hearts for transplantation. 6 The explanted heart is placed on a Langendorff-based commercial apparatus known as the TransMedics Organ Care System (TransMedics Inc., Boston, MA, USA), primed with donor blood, where the hearts are re-perfused, reanimated and transported warm, perfused and beating to the implantation centre. Cardiac biochemical and metabolic function may be assessed while on the apparatus by sampling heart perfusate inflow and coronary sinus effluent.…”

Section: Discussionmentioning

confidence: 99%

The practicalities of establishing a porcine isolated heart model

et al. 2017

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“…In 2013 Dithal et al reported the first NHBD heart transplantation utilizing the newly introduced Organ Care System (OCS) (TransMedics; Andover, MA, USA) [ 22 ]. OCS enables both standard and marginal criteria for ex-vivo donor hearts to be preserved and enables detection of occult pathology during normothermic ex-vivo perfusion [ 23 ].…”

Section: Clinical Success In Adult Hearts From Nhbdsmentioning

confidence: 99%

Non-Heart-Beating Donor Heart Transplantation: Breaking the Taboo

Fatullayev

Samak

Sabashnikov

et al. 2015

Med Sci Monit Basic Res

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Roughly 60% of hearts offered for transplantation are rejected because of organ dysfunction. Moreover, hearts from circulatory-dead patients have long been thought to be non-amenable for transplantation, unlike other organs. However, tentative surgical attempts inspired by the knowledge obtained from preclinical research to recover those hearts have been performed, finally culminating in clinically successful transplants. In this review we sought to address the major concerns in non-heart-beating donor heart transplantation and highlight recently introduced developments to overcome them.

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Heart Transplantation From Donation After Circulatory Death Donors

Cited by 12 publications

References 16 publications

External validation of prediction models for time to death in potential donors after circulatory death

External validation of prediction models for time to death in potential donors after circulatory death

The practicalities of establishing a porcine isolated heart model

Non-Heart-Beating Donor Heart Transplantation: Breaking the Taboo

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