Heart rate variability - current diagnosis of the cardiac autonomic neuropathy. A review

Metelka, Rudolf

doi:10.5507/bp.2014.025

Cited by 61 publications

(55 citation statements)

References 68 publications

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“…With different types of mathematical processing, the HRV analysis is presented in the frequency band and/or time component. Three spectral power bands can be calculated by a 5-min recording, including very low frequency (VLF), low frequency (LF), and high frequency (HF) [6] . The physiological nature of VLF is still uncertain but possibly related to thermoregulatory sympathetic vascular activity and oscillations in the renin-angiotensin system [6] .…”

Section: Synergic Impact Of Vascular Calcification and Low Autonomic mentioning

confidence: 99%

“…Three spectral power bands can be calculated by a 5-min recording, including very low frequency (VLF), low frequency (LF), and high frequency (HF) [6] . The physiological nature of VLF is still uncertain but possibly related to thermoregulatory sympathetic vascular activity and oscillations in the renin-angiotensin system [6] . LF band is derived from neural mechanisms linked to sympathetic and vagal outflow.…”

Section: Synergic Impact Of Vascular Calcification and Low Autonomic mentioning

confidence: 99%

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Synergic Impact of Vascular Calcification and Low Autonomic Tone in Mortality of Hemodialysis Patients

Hsueh²,

Lee³

et al. 2017

Nephron

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Background: Both cardiovascular calcification and autonomic dysfunction are frequently encountered in hemodialysis patients. We aimed to investigate the relationship between cardiovascular calcification and heart rate variability (HRV) and their influence on long-term outcome. Methods: Seventy-eight hemodialysis patients underwent echocardiogram and radiography of the pelvis and hands to identify valvular and vascular calcification. HRV was evaluated using a commercial machine. Results: Based on the average, the patients were divided into higher and lower subgroups of high frequency (HF) and low frequency (LF) respectively. Patients with higher LF were younger and were found to have a lower proportion of diabetes. Their hemoglobin, albumin, and bone morphogenic protein (BMP)-7 levels were significantly higher and both high-sensitive C-reactive protein (hs-CRP) and osteoprotegerin levels were lower (all p < 0.05). In patients of the higher HF group, the proportion of diabetes was lower but they were found to have higher levels of BMP-7 and lower levels of hs-CRP, interleukin-6 (all p < 0.05). Significantly higher LF and HF were noted in patients without vascular calcification, but only hand artery (HA) calcification was negatively correlated with both LF and HF in multivariate analysis. Low LF and high hs-CRP were the independent predictors of mortality. Coexistence of low LF band and HA calcification was associated with the worse outcome. Conclusions: Abnormal autonomic nervous function was closely related to inflammation and mortality in hemodialysis patients. Calcification of HA was associated with autonomic dysfunction and patients with lower autonomic tone and HA calcification had the highest mortality rate in this population.

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Section: Synergic Impact Of Vascular Calcification and Low Autonomic mentioning

confidence: 99%

Section: Synergic Impact Of Vascular Calcification and Low Autonomic mentioning

confidence: 99%

Synergic Impact of Vascular Calcification and Low Autonomic Tone in Mortality of Hemodialysis Patients

Hsueh²,

Lee³

et al. 2017

Nephron

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“…However, the heart rate variability was altered in wild type mice fed a cholesterol-enriched diet, indicating a predominance of sympathetic drive over the vagal tonus to the heart, as opposite of what was seen in the control mice. Both, vagal drive reduction as well as sympathetic activity increase is associated with higher incidence of ischemic cardiac events, chronic degenerative diseases, lethal arrhythmias, and sudden death [20][21][22]. A similar effect of this diet in the autonomic balance has been reported in mice knockout for the LDL receptor [23], in non-obese diabetic mice [16], as well as in a model of familial hypertrophic cardiomyopathy characterized by contractile dysfunction [24].…”

Section: Discussionmentioning

confidence: 65%

β2-Adrenoceptors Antiarrhythmic Effects in Wild Type Mice Fed a Cholesterol-Enriched Diet

Ternes¹,

Souza²,

Cruz³

et al. 2016

Cardiovasc Pharm Open Access

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The systematic intake of an unbalanced diet is an important risk factor for cardiovascular diseases, the leading cause of death in the entire world. Most of the studies address this issue using genetically manipulated mice. This study aims to investigate the effect of the intake of a cholesterol-enriched diet on cardiac and hemodynamic parameters in conscious wild type mice. Twenty male, three-month-old C57BL/6 mice were distributed in two groups: (CTL) control, with mice receiving standard commercial chow and (CHO) cholesterol group, with mice receiving a cholesterol-enriched diet during 15 days. Catheters were implanted in the carotid artery and jugular vein for blood pressure and heart rate recording and drugs administration. Electrodes were implanted for electrocardiogram recording and spectral analysis of heart rate variability. Glucose, cholesterol, and triglycerides were determined in blood samples and histopathological analysis of the aorta was performed. Serum cholesterol and glucose, mean arterial pressure and heart rate were higher in CHO than CTL mice. CHO mice also exhibited predominance of sympathetic over parasympathetic tonus to the heart, and higher responsiveness to the chronotropic effect of isoproterenol. Arrhythmic episodes, present only in the CHO mice, were cancelled by metoprolol and exacerbated by ICI118,551. It is concluded that the intake of high cholesterol diet causes hypertension and heart rhythm irregularities. Because those effects are exacerbated by the blockade of β 2 -adrenergic receptor and attenuated by the blockade of β 1 -adrenergic receptor, data highlights a possible antiarrhythmic protective role played by β 2 -AR subtype.

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“…The assessment of CAN was performed under strictly standardized conditions by a bedside on-line telemetric transmitter (VarCor PF7, DIMEA Group, Olomouc, Czech Republic). International recommendations were used for evaluation of the results 3,4 . Three tests from the Ewing battery were selected for CAN assessment: (i) Heart rate variability in response to deep breathing (parameter I/E), (ii) Laying-to-standing heart rate response (parameter RRmax/RRmin), (iii) Postural blood pressure change.…”

Section: Methodsmentioning

confidence: 99%

The influence of cardiovascular autonomic neuropathy on mortality in type 1 diabetic patients; 10-year follow-up

Lacigová

Brožová

Cechurová

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aim. The aim of our retrospective study was to answer the question if the presence of cardiovascular autonomic neuropathy (CAN) affects mortality in type 1 diabetic patients during a 10-year follow-up. Methods. Patients with type 1 diabetes mellitus examined for CAN in 2003 were enrolled in this retrospective study. A total of 278 patients were included and divided into two groups according to the presence or absence of CAN (111 CAN+, 167 CAN-). The group characteristics and outcomes were compared at baseline and after ten years (in 2013). Results. In the follow-up period, a total of 18 patients died; CAN+ (14/111; 12.6%) and CAN-(4/167; 2.4%) (P < 0.001). At baseline, the CAN+ patients were older (47 vs. 33 years; P < 0.001), had longer duration of diabetes (20 vs. 12 years; P < 0.05), had worse glycemic control assessed by HbA1c (73 vs. 68 mmol/mol; P < 0.05), higher systolic (130 vs. 120 mmHg; P < 0.001) and diastolic (80 vs. 70 mmHg; P < 0.01) blood pressure and had more diabetic complications. In our analysis we found the strongest predictor of mortality to be the presence of CAN (P < 0.01) and the blood pressure value at baseline (P < 0.05). Other baseline characteristics, including the duration of diabetes, age and the presence of micro-and macrovascular complications were not significant. The statistical analysis was performed using logistic regression step-wise analysis. Conclusions. During the 10-year follow-up, CAN+ patients had a 5-fold higher mortality rate than CAN-patients. The strongest predictor of mortality was the presence of CAN.

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Heart rate variability - current diagnosis of the cardiac autonomic neuropathy. A review

Cited by 61 publications

References 68 publications

Synergic Impact of Vascular Calcification and Low Autonomic Tone in Mortality of Hemodialysis Patients

Synergic Impact of Vascular Calcification and Low Autonomic Tone in Mortality of Hemodialysis Patients

β2-Adrenoceptors Antiarrhythmic Effects in Wild Type Mice Fed a Cholesterol-Enriched Diet

The influence of cardiovascular autonomic neuropathy on mortality in type 1 diabetic patients; 10-year follow-up

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