Heart Rate Variability Analysis at Coronary Artery Disease and Angina Pectoris

Abstract

The purpose of this study was to present results of special examination and prospective observation of patients with coronary artery disease (CAD) and angina pectoris (AP) in practical cardiology. Except standard cardiological methods, we used high-resolution rhythmocardiography and apparatus-program complex for registration and analysis of the heart rate variability. There was an evaluation of the autonomic and humoral-metabolic regulative influences on pacemaker activity of the heart sinus node in 273 patients selected by criteria of including-excluding patients with CAD and AP. It was determined by high-resolution HRV-analysis that ischemic heart disease is accompanied by the sinus node autonomic and humoral disregulation. Angina pectoris was correlated to HRV-stabilization on the rhythmocardiogram during ischemic episodes. Duration and frequency of these HRV-stabilization episodes permit to describe different peculiarities of the angina pectoris in every case, to predict the complication, for example, acute coronary syndrome, to define risk of lethal outcome, to study autonomic efficacy of the same drug (nitroglycerin). Prospective observations of patients with CAD permitted to create ischemic cascade in HRV-symptoms. The following conclusion can be made. High-resolution HRV analysis is an informative and perspective method in the diagnosis and management of CAD and AP. Recent patents have also disclosed methods and apparatus to reduce heart rate variability and assessment of cardiovascular risks.

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations

“…50,51 Although specific studies linking HRV with the risk of cardiovascular disease in patients with SLE have not been performed, it is unlikely that the finding that HRV measures may assist in the management of coronary artery disease in other patient populations would not also be true in SLE, as it has been shown that impaired functioning of the ANS is a negative prognostic factor in patients with acute coronary syndromes and is associated with increased cardiovascular risk. 52 Thus HRV can potentially be used to assess the severity of autonomic dysfunction in SLE patients and studies of changes in HRV with interventions may lead to ways to decrease potential cardiovascular risk in SLE. As a result, HRV assessment may prove to be useful in clinical practice regarding the care of patients with SLE.…”

The role of revascularization on short-term Heart Rate Variability (HRV) and Signal Averaged Electrocardiogram (SAECG) in Stable Coronary Artery Disease (CAD)

“…3 Patients with SCAD may experience HRV alteration due to increased sympathetic activities. 4 HRV measurements have different time intervals; short-term HRV (5-10 minutes) is similar to long term HRV (24 hours) in terms of risk stratification for ischemic heart diseases.…”