Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study

Palatini, Paolo; Dorigatti, Francesca; Zaetta, Vania; Mormino, Paolo; Mazzer, Adriano; Bortolazzi, A.; D’Este, D; Pegoraro, F.; Milani, L.; Mos, Lucio

doi:10.1097/01.hjh.0000242413.96277.5b

Cited by 123 publications

(71 citation statements)

References 46 publications

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“…This observation is consistent with results from the Hypertension and Ambulatory Recording Venetia Study, where baseline clinic HR and HR changes during follow-up were independent predictors for the development of sustained hypertension in young people with stage 1 hypertension. 23 The procedures for HR recording in this study complied with European Society of Hypertension consensus recommendations. 24 Patients rested for 5 minutes before measurement of pulse rate over 1 minute, and an average of 3 measurements was taken.…”

Section: Discussionmentioning

confidence: 99%

Resting Heart Rate Pattern During Follow-Up and Mortality in Hypertensive Patients

et al. 2010

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Abstract-There is a linear relationship between resting heart rate (HR) and mortality in normotensive and untreated hypertensive individuals. However, it is not clear whether HR is a marker of increased risk in hypertensive patients on treatment. We investigated the relationship between HR and mortality in patients with hypertension. We analyzed baseline HR, final HR, and HR change during follow-up in patients attending the Glasgow Blood Pressure Clinic. Using a threshold of 80 bpm, we classified patients into those who had a consistently high (high-high) or low (low-low) HR or patients whose HR increased (low-high) or decreased (high-low) over time. Survival analysis was carried out using Cox proportional hazards models adjusted for age, sex, body mass index, smoking, rate-limiting therapy, systolic blood pressure, and serum cholesterol. For each beat of HR change there was a 1% change in mortality risk. The highest risk of an all-cause event was associated with patients who had increased their HR by Ն5 bpm at the end of follow-up (

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Section: Discussionmentioning

confidence: 99%

Resting Heart Rate Pattern During Follow-Up and Mortality in Hypertensive Patients

et al. 2010

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“…The persistent tachycardia during 6-year follow-up, but not transient tachycardia, was able to predict the risk of hypertension. 24 In a 20-year follow-up in a general population, it has been shown that a higher HR was able to predispose to obesity and diabetes mellitus. 25 A 30% increase in the risk for obesity was observed for each 10 bpm increase in baseline HR.…”

Section: Predictive Power Of Heart Ratementioning

confidence: 99%

Heart Rate as a Marker of Cardiovascular Prognosis

Seravalle¹

2016

Hypertension Journal

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Although several studies have shown that elevated heart rate (HR) is a powerful, independent, and consistent predictor of cardiovascular events and all-cause mortality, it is still considered an epiphenomenon of a general disorder rather than an independent risk factor. Several questions regarding the clinical significance of a resting HR as marker of cardiovascular risk are still unanswered, rendering the inclusion of this hemodynamic variable in the list of cardiovascular risk factors problematic, at least for time being. This paper will examine which HR value better reflects the cardiovascular risk, the predictive power, the complex pathophysiological mechanisms underlying the relationship between HR and cardiovascular risk. It will evaluate whether HR should be considered a true risk factor for cardiovascular diseases or simply a marker of autonomic imbalance, and finally, it will consider the effects of HR reduction on cardiovascular morbidity.

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“…Cutoffs for CI and SVRI were adopted from the previous studies of Taler et al [5] and Smith et al [6]. Increased rest HR (> 80/min) was considered an indication for BB use due to the fact that it had been reported to be unfavorable for prognosis [15]. The different cut-off values for TFC for men and women were defined based on sex-dependant computational calculation used in Niccomo device.…”

Section: Treatmentmentioning

confidence: 99%

The effect of hemodynamically-guided hypotensive therapy in one-year observation: Randomized, prospective and controlled trial (FINEPATH study)

Krzesiński¹,

Gielerak

Stańczyk

et al. 2016

Cardiol J.

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Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study

Abstract: Baseline clinic heart rate and heart rate changes during the first few months of follow-up are independent predictors of the development of sustained hypertension in young persons screened for stage 1 hypertension.

Cited by 123 publications

References 46 publications

Resting Heart Rate Pattern During Follow-Up and Mortality in Hypertensive Patients

Resting Heart Rate Pattern During Follow-Up and Mortality in Hypertensive Patients

Heart Rate as a Marker of Cardiovascular Prognosis

The effect of hemodynamically-guided hypotensive therapy in one-year observation: Randomized, prospective and controlled trial (FINEPATH study)

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