Heart mitochondrial and microsomal phospholipid fluctuations induced by chronic exercise in rats

Kalofoutis, A.; Lekakis, John; Miras, C. J.

doi:10.1016/0020-711x(81)90156-7

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Specific changes in membrane phospholipid composition also have been reported in response to exercise training (17,20,31). Tibbits et al (31) reported a significant increase in cardiac sarcolemmal phosphatidylserine (PS), with no change in phosphatidylethanolamine (PE), PC and P1 in response to exercise training.…”

Section: Introductionmentioning

confidence: 87%

“…Using rat heart sarcolemmal, Tibbits et al (31) showed a remarkable 51% increase in PS after exercise training, as compared to untrained groups. In rat heart microsomal tissue Kalofoutis et al (17) observed a significant decrease in PS (14%) after exercise training. They also observed similar finding for heart mitochondrial PS (17).…”

Section: Heart Phosphatidylserine (Ps)mentioning

confidence: 95%

“…In rat heart microsomal tissue Kalofoutis et al (17) observed a significant decrease in PS (14%) after exercise training. They also observed similar finding for heart mitochondrial PS (17). The precise mechanism responsible for the cardiac PS changes after exercise training is uncertain.…”

Section: Heart Phosphatidylserine (Ps)mentioning

confidence: 95%

“…The depletion of myocardial membrane PE has been implicated in the Ca2 hyperpermeability defect that occurs in response to myocardial ischemia (5, 28). Kalofoutis et al (17) reported a decline in heart mitochondria and microsome PE contents after exercise training. In the whole heart tissue, we also observed a decline in PE content with exercise training.…”

Section: Heart Phosphatidylethanolamine (Pe)mentioning

confidence: 99%

“…Heart Phosphatidyicholine (PC) Using mitochondrial tissue, Kalofoutis et al (17) observed a decrease in heart PC in the trained rats compared with the sedentary rats. In the whole heart tissue, we observed an increase in myocardial PC, with little change in CL in the exercise-trained and the exercise plus steroid-treated groups.…”

Section: Heart Phosphatidylserine (Ps)mentioning

confidence: 99%

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NMR Spectroscopy Study of Heart Phospholipids

Liang

Glonek²,

Meneses³

et al. 1992

Int J Sports Med

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Because 31P NMR spectral analysis of phospholipid (PL) is an accurate and rapid technique for resolving the quantity of PL resonances and involving minimum chemical manipulations that may affect the integrity of the tissue (24-26), we studied the effect of anabolic steroid injection, exercise training, or a combination of both treatments on whole heart phospholipids using 31P NMR spectral analysis. Male Sprague-Dawley rats were randomly assigned to 4 groups of 11 each: sedentary control (C), steroid-treated (ST), exercise-trained (E), and exercise plus steroid-treated (ES). The ST and ES rats were administered nandrolone decanoate by i.m. injection every 7-9 d during the 10 wk study, while the C and E rats were injected with glycerol. The exercise rats ran on a treadmill, wearing a collar weight for 50 min/day, 5 days/wk. There was a significant difference in body wt among the four groups at the conclusion of the study; however, no significant differences in heart wt or in the ratio of heart wt:body wt were observed among the four groups. Myocardial phospholipid profiles of the exercise-trained rats were significantly (p less than 0.05) different from those of the untrained rats. The changes were enhanced somewhat by the steroid treatment. The profiles differed in the relative amounts of four of the nine myocardial phospholipids detected: phosphatidylcholine, phosphatidylethanolamine (PE), PE plasmalogen, and phosphatidylserine. We conclude that the observed changes in whole heart phospholipid compositions are due to experimental treatment specifically from exhaustive exercise and not from anabolic steroids or cardiac hypertrophy.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 87%

Section: Heart Phosphatidylserine (Ps)mentioning

confidence: 95%