Heart Function in Patients with Chronic Glomerulonephritis and Mildly to Moderately Impaired Renal Function: An Echocardiographic Study

Schroeder, Anne Pauline; Kristensen, Bent Bruun; Nielsen, C. B.; Pedersen, E. B.

doi:10.3109/08037059709062084

Cited by 22 publications

(21 citation statements)

References 43 publications

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“…33 and the presence of commonly associated comorbidities such as hypertension, diabetes, and anemia explain only part of the left ventricular remodeling. [44][45][46] The molecular basis for these changes includes activation of growth factors, proto-oncogenes, plasma noradrenalin, cytokines, and angiotensin II. These factors regulate intracellular processes that accelerate cardiac hypertrophy, myocardial fibrosis, and apoptosis.…”

Section: Possible Mechanismsmentioning

confidence: 99%

CKD and Sudden Cardiac Death

Whitman¹,

Feldman

Deo

2012

Journal of the American Society of Nephrology

118

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Multiple studies demonstrate a strong independent association between CKD and cardiovascular events including death, heart failure, and myocardial infarction. This review focuses on recent clinical studies that expand this spectrum of adverse cardiovascular events to include ventricular arrhythmias and sudden cardiac death. In addition, experimental models suggest structural remodeling of the heart and electrophysiologic changes in this population. These processes may explain the increased arrhythmic risk in kidney disease and aid in identifying patients who are at higher risk for sudden cardiac death. Finally, we review here the data to support the use of pharmacologic and device-based therapies for both the primary and secondary prevention of sudden cardiac death.

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Section: Possible Mechanismsmentioning

confidence: 99%

CKD and Sudden Cardiac Death

Whitman¹,

Feldman

Deo

2012

Journal of the American Society of Nephrology

118

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“…LV mass has also been related to proteinuria and microalbuminuria in such patients (5,21,22). As for LV function, it has been reported that patients with renal insufficiency had both systolic and diastolic dysfunction (23). Furthermore, weak associations have been shown between microalbuminuria and indices of LV diastolic function (5).…”

Section: Discussionmentioning

confidence: 99%

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

et al. 2003

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The heart and kidneys are important target organs in hypertension. Early signs of hypertensive target organ Abnormalities in left ventricular (LV) diastolic filling have been described in patients with hypertension, even in the absence of left ventricular hypertrophy (7-9). Moreover, impaired LV diastolic relaxation is a prognostic indicator of cardiovascular risk (10). An increased intrarenal resistance index (RI) evaluated by renal Doppler ultrasonography has also been reported in patients with essential hypertension (11,12). Assessment of intrarenal vascular resistance is useful in determining the degree of intrarenal damage. High levels of RI are associated with subclinical end-organ damage-namely microalbuminuria, LV hypertrophy, and carotid atherosclerosis-in hypertensive patients (13,14). In addition, an RI value of ≥ 0.8 is a strong and independent

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“…In addition, among participants with CKD most advanced dialysis, magnetic resonance imaging (MRI) contrast exhibits a diffuse pattern image with gadolinium uptake, suggestive of fibrosis and nonischemic cardiomyopathy [37]. The pathogenesis of these conditions is considered manifold [38][39][40]. CKD is also associated with vascular disease, including calcification and inurement of the blood vessels [41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Predictors for atrial fibrillation onset in CKD patients with pacemaker

Kiuchi¹,

Chen²

2017

Nephrol Renal Dis

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Aim: To assess the hypothesis that chronic kidney disease (CKD) may affect the incidence of AF, the present study investigated the influence of renal impairment and CKD on the new onset of AF in this population. Methods:A cohort of inividuals received standard therapy for treatment of sinus node disease (SND), and second-or third-degree atrioventricular block (AVB), DDDR pacemaker implantation. The maximum follow-up period was 6 years after the implantation procedure.Results: CKD, age, hypertension, smoking, left ventricular mass index (LVMI), left atrial diameter (LAD), and pacemakers implanted due to 2 nd or 3 rd degree AVB were significantly different (defined as P<0.1) between the no CKD and CKD population in the univariate Cox logistic regression model. All of them except hypertension were significant (P<0.05) in the multivariate Cox logistic regression model. Independent predictors of AF incidence were re-examined by stepwise regression analysis including all clinical and echocardiographic variables as possible independent factors. The presence of CKD as well as age, smoking, LVMI, LAD, and AVB was an independent predictor of new-onset AF (age, hazard ratio (HR): 1.031, 95% confidence interval (CI): 1.023 -1.038, P<0.0001; smoking, HR: 1.315, 95%CI: 1.110 -1.558, P=0.0020; LVMI, HR:1.017, 95%CI: 1.013 -1.020, P=0.0020; LAD, HR: 1.281, 95%CI: 1.241 -1.322, P<0.0001; AVB, HR: 1.240, 95%CI: 1.087 -1.415, P=0.0010; and CKD, HR: 2.073, 95% CI: 1.616 -2.660, P<0.0001). The association of CKD stages with the incidence of AF was lastly evaluated by the univariate Cox analysis, the occurrence of new-onset AF was significantly increased in the participant groups with CKD stage 3, 4 and 5 before and after adjustment for confounding factors, being significantly associated with the increased incidence of AF. Conclusions:The present study demonstrated that CKD was associated with an increased risk of new onset AF in patients with pacemakers and that the impact of CKD on the incidence of AF was independent of LV hypertrophy and LA dilatation. In particular, moderate to later stages of CKD were strongly related to the increasing occurrence of AF.

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Heart Function in Patients with Chronic Glomerulonephritis and Mildly to Moderately Impaired Renal Function: An Echocardiographic Study

Cited by 22 publications

References 43 publications

CKD and Sudden Cardiac Death

CKD and Sudden Cardiac Death

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

Predictors for atrial fibrillation onset in CKD patients with pacemaker

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