Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

Abstract

The heart and kidneys are important target organs in hypertension. Early signs of hypertensive target organ Abnormalities in left ventricular (LV) diastolic filling have been described in patients with hypertension, even in the absence of left ventricular hypertrophy (7-9). Moreover, impaired LV diastolic relaxation is a prognostic indicator of cardiovascular risk (10). An increased intrarenal resistance index (RI) evaluated by renal Doppler ultrasonography has also been reported in patients with essential hypertension (11,12). Assessment of intrarenal vascular resistance is useful in determining the degree of intrarenal damage. High levels of RI are associated with subclinical end-organ damage-namely microalbuminuria, LV hypertrophy, and carotid atherosclerosis-in hypertensive patients (13,14). In addition, an RI value of ≥ 0.8 is a strong and independent

The Beneficial Impact of Fasudil and Sildenafil on Monocrotaline-Induced Pulmonary Hypertension in Rats: A Hemodynamic and Biochemical Study

“…In our study, a 14-day administration of sildenafil to rats with MCT-induced PH also resulted in a significant decrease of BNP level. These observations suggest that PDE-5 inhibitor therapy could ameliorate increased wall stress in the right ventricle and impaired left ventricle diastolic function due to the enlarged right ventricle in PH [27,28,29]. The observed positive impact on decrease of BNP plasma level was also attributed to fasudil.…”

Long-Term Vardenafil Therapy Improves Hemodynamics in Patients with Pulmonary Hypertension

“…The baseline plasma level of BNP, which is a prognostic indicator in patients with PH (24), was significantly increased in our patients. The long-term treatment with vardenafil caused a significant reduction of the BNP level, suggesting that the decrease in pulmonary artery pressure ameliorated increased wall stress (25,26) in the right ventricle and impaired left ventricle diastolic function (27)(28)(29) due to the enlarged right ventricle of those patients.…”

Prevalence and correlates of multiple organ damage in referred treated hypertensives: data from the ETODH study

“…[10][11][12] In this study, patients with multiple OD (that is, LVH, carotid atherosclerosis and MA) were older, more frequently males, and had higher systolic BP, longer duration of hypertension, greater prevalence of type 2 diabetes, metabolic syndrome and smoking. This underlines the synergic role of several modifiable and non-modifiable risk factors in the development of cardiac and extra-cardiac OD.…”